Persistent fibrosis, hypertrophy and sarcomere disorganisation after endoscopy-guided heart resection in adult Xenopus.

Autor: Lindsey Marshall, Céline Vivien, Fabrice Girardot, Louise Péricard, Barbara A Demeneix, Laurent Coen, Norin Chai

Publikováno v: PLoS ONE, Vol 12, Iss 3, p e0173418 (2017)

Models of cardiac repair are needed to understand mechanisms underlying failure to regenerate in human cardiac tissue. Such studies are currently dominated by the use of zebrafish and mice. Remarkably, it is between these two evolutionary separated s

Externí odkaz: https://doaj.org/article/40cb807c98d64d51819b64dd1d686736

Ventx factors function as Nanog-like guardians of developmental potential in Xenopus.

Autor: Pierluigi Scerbo, Fabrice Girardot, Céline Vivien, Gabriel V Markov, Guillaume Luxardi, Barbara Demeneix, Laurent Kodjabachian, Laurent Coen

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e36855 (2012)

Vertebrate development requires progressive commitment of embryonic cells into specific lineages through a continuum of signals that play off differentiation versus multipotency. In mammals, Nanog is a key transcription factor that maintains cellular

Externí odkaz: https://doaj.org/article/9b009d475c41471ebfce853cd84048f7

Stage-dependent cardiac regeneration in Xenopus is regulated by thyroid hormone availability

Autor: Fabrice Girardot, Céline Vivien, Louise Péricard, Karima Palmier, Pierluigi Scerbo, Laurent Coen, Lindsey Marshall, Barbara A. Demeneix

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (9), pp.3614-3623. ⟨10.1073/pnas.1803794116⟩
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (9), pp.3614-3623. ⟨10.1073/pnas.1803794116⟩

International audience; Despite therapeutic advances, heart failure is the major cause of morbidity and mortality worldwide, but why cardiac regenerative capacity is lost in adult humans remains an enigma. Cardiac regenerative capacity widely varies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e0c25f3f86c62836be6e4bae6285ca
https://hal.archives-ouvertes.fr/hal-03319960

In Vivo Transfection of Naked DNA into

Autor: Lindsey, Marshall, Fabrice, Girardot, Barbara A, Demeneix, Laurent, Coen

Publikováno v: Cold Spring Harbor protocols. 2017(11)

In vivo gene transfer systems are important to study foreign gene expression and promoter regulation in an organism, with the benefit of exploring this in an integrated environment. Direct injection of plasmids encoding exogenous promoters and genes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::974e7b3c53a4e9459669cae3a9b07c97
https://pubmed.ncbi.nlm.nih.gov/29093206

On the origin and evolutionary history of NANOG

Autor: Céline Vivien, Barbara A. Demeneix, Gabriel V. Markov, Laurent Coen, Pierluigi Scerbo, Laurent Kodjabachian, Fabrice Girardot

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2014, 9 (1), pp.e85104. ⟨10.1371/journal.pone.0085104⟩
PLoS ONE, 2014, 9 (1), pp.e85104. ⟨10.1371/journal.pone.0085104⟩
PLoS ONE, Vol 9, Iss 1, p e85104 (2014)

International audience; Though pluripotency is well characterized in mammals, many questions remain to be resolved regarding its evolutionary history. A necessary prerequisite for addressing this issue is to determine the phylogenetic distributions a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c92480c5f98b5ce62d469c6d722cac9
https://hal.archives-ouvertes.fr/hal-01111124