Homocysteine Metabolism Pathway Is Involved in the Control of Glucose Homeostasis: A Cystathionine Beta Synthase Deficiency Study in Mouse

Autor: Céline Cruciani-Guglielmacci, Kelly Meneyrol, Jessica Denom, Nadim Kassis, Latif Rachdi, Fatna Makaci, Stéphanie Migrenne-Li, Fabrice Daubigney, Eleni Georgiadou, Raphaël G. Denis, Ana Rodriguez Sanchez-Archidona, Jean-Louis Paul, Bernard Thorens, Guy A. Rutter, Christophe Magnan, Hervé Le Stunff, Nathalie Janel

Publikováno v: Cells, Vol 11, Iss 11, p 1737 (2022)

Cystathionine beta synthase (CBS) catalyzes the first step of the transsulfuration pathway from homocysteine to cystathionine, and its deficiency leads to hyperhomocysteinemia (HHcy) in humans and rodents. To date, scarce information is available abo

Externí odkaz: https://doaj.org/article/e39e5da75b8443ba9489a6fbff84e319

Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage

Autor: Benoit Souchet, Fayçal Guedj, Ignasi Sahún, Arnaud Duchon, Fabrice Daubigney, Anne Badel, Yuchio Yanagawa, Maria Jose Barallobre, Mara Dierssen, Eugene Yu, Yann Herault, Mariona Arbones, Nathalie Janel, Nicole Créau, Jean Maurice Delabar

Publikováno v: Neurobiology of Disease, Vol 69, Iss , Pp 65-75 (2014)

Cognitive deficits in Down syndrome (DS) have been linked to increased synaptic inhibition, leading to an imbalance of excitation/inhibition (E/I). Various mouse models and studies from human brains have implicated an HSA21 gene, the serine/threonine

Externí odkaz: https://doaj.org/article/38eb53d8da744590b164b4cc0d3230c4

LPS-Induced Inflammation Abolishes the Effect of DYRK1A on IkB Stability in the Brain of Mice

Autor: Michel Mallat, Fabrice Daubigney, Catherine Colin, Sandrine Middendorp, Jean-Christophe Rain, Nadim Kassis, Valerie Hindie, M.L. Arbonés, Blandine Gausserès, Jean-Maurice Delabar, Jean-Louis Paul, Nathalie Janel, Yuchen Gu, Eugene Yu, Alizée Latour

Publikováno v: Molecular Neurobiology
Molecular Neurobiology, Humana Press, 2019, 56 (2), pp.963-975. ⟨10.1007/s12035-018-1113-x⟩
Digital.CSIC. Repositorio Institucional del CSIC
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International audience; Down syndrome is characterized by premature aging and dementia with neurological features that mimic those found in Alzheimer's disease. This pathology in Down syndrome could be related to inflammation, which plays a role in o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab1f26769338a1ae350f08e7f4bdceea
https://hal-cnrs.archives-ouvertes.fr/hal-03201563

Effect of cadmium administration in hyperhomocysteinemic mice due to cystathionine beta synthase deficiency

Autor: Gautier Moroy, Jean-Louis Paul, Camille Ramambason, Nathalie Janel, Fabrice Daubigney

Publikováno v: Experimental and Toxicologic Pathology. 68:365-370

Homocysteine, a sulfur-containing amino acid formed during the metabolism of methionine, is commonly slightly elevated in the plasma of the general population. Additionally, we previously found that cystathionine beta synthase-deficient mice, a murin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4df1cda79569d61be69838c47cec24
https://doi.org/10.1016/j.etp.2016.05.001

Overexpression of the DYRK1A Gene (Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A) Induces Alterations of the Serotoninergic and Dopaminergic Processing in Murine Brain Tissues

Autor: Julien Dairou, Jacqueline London, Benoit Souchet, Linh Chi Bui, Fabrice Daubigney, Christophe Magnan, Nathalie Janel, Serge Luquet, Jean-Maurice Delabar, Hind Medjaoui, Elodie Assayag, Claude Rouch

Publikováno v: Molecular Neurobiology
Molecular Neurobiology, Humana Press, 2018, 55, pp.3822-3831. ⟨10.1007/s12035-017-0591-6⟩

International audience; Trisomy 21 (T21) or Down syndrome (DS) is the most common genetic disorder associated with intellectual disability and affects around 5 million persons worldwide. Neuroanatomical phenotypes associated with T21 include slight r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3180c76ec84b333056e81dc85461e1d
https://hal-cnrs.archives-ouvertes.fr/hal-03105437