Výsledky vyhledávání - "Fabrice Confalonieri"

Akademický článek

Natural Transformation in Deinococcus radiodurans: A Genetic Analysis Reveals the Major Roles of DprA, DdrB, RecA, RecF, and RecO Proteins

Autor: Solenne Ithurbide, Geneviève Coste, Johnny Lisboa, Nicolas Eugénie, Esma Bentchikou, Claire Bouthier de la Tour, Dominique Liger, Fabrice Confalonieri, Suzanne Sommer, Sophie Quevillon-Cheruel, Pascale Servant

Publikováno v: Frontiers in Microbiology, Vol 11 (2020)

Horizontal gene transfer is a major driver of bacterial evolution and adaptation to environmental stresses, occurring notably via transformation of naturally competent organisms. The Deinococcus radiodurans bacterium, characterized by its extreme rad

Externí odkaz: https://doaj.org/article/da0ee5088287431eb50f82896bd25fb2

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Akademický článek

Characterization of the Radiation Desiccation Response Regulon of the Radioresistant Bacterium Deinococcus radiodurans by Integrative Genomic Analyses

Autor: Nicolas Eugénie, Yvan Zivanovic, Gaelle Lelandais, Geneviève Coste, Claire Bouthier de la Tour, Esma Bentchikou, Pascale Servant, Fabrice Confalonieri

Publikováno v: Cells, Vol 10, Iss 10, p 2536 (2021)

Numerous genes are overexpressed in the radioresistant bacterium Deinococcus radiodurans after exposure to radiation or prolonged desiccation. It was shown that the DdrO and IrrE proteins play a major role in regulating the expression of approximatel

Externí odkaz: https://doaj.org/article/1a59b173fec543a981d2f30b67a43d8f

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Akademický článek

Platinum nanoparticles: an exquisite tool to overcome radioresistance

Autor: Sha Li, Erika Porcel, Hynd Remita, Sergio Marco, Matthieu Réfrégiers, Murielle Dutertre, Fabrice Confalonieri, Sandrine Lacombe

Publikováno v: Cancer Nanotechnology, Vol 8, Iss 1, Pp 1-15 (2017)

Abstract Backgroud Small metallic nanoparticles are proposed as potential nanodrugs to optimize the performances of radiotherapy. This strategy, based on the enrichment of tumours with nanoparticles to amplify radiation effects in the tumour, aims at

Externí odkaz: https://doaj.org/article/befe4f23c4ac4a49809fbd2e879ab53b

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Akademický článek

In vivo and in vitro characterization of DdrC, a DNA damage response protein in Deinococcus radiodurans bacterium.

Autor: Claire Bouthier de la Tour, Martine Mathieu, Laura Meyer, Pauline Dupaigne, Fanny Passot, Pascale Servant, Suzanne Sommer, Eric Le Cam, Fabrice Confalonieri

Publikováno v: PLoS ONE, Vol 12, Iss 5, p e0177751 (2017)

The bacterium Deinococcus radiodurans possesses a set of Deinococcus-specific genes highly induced after DNA damage. Among them, ddrC (dr0003) was recently re-annotated, found to be in the inverse orientation and called A2G07_00380. Here, we report t

Externí odkaz: https://doaj.org/article/2c3a82f50e004327abb611af685f953f

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Akademický článek

Multiple and variable NHEJ-like genes are involved in resistance to DNA damage in Streptomyces ambofaciens

Autor: Grégory Hoff, Claire Bertrand, Lingli Zhang, Emilie Piotrowski, Ludovic Chipot, Cyril Bontemps, Fabrice Confalonieri, Stephen McGovern, François Lecointe, Annabelle Thibessard, Pierre Leblond

Publikováno v: Frontiers in Microbiology, Vol 7 (2016)

Non homologous end-joining (NHEJ) is a double strand break (DSB) repair pathway which does not require any homologous template and can ligate two DNA ends together. The basic bacterial NHEJ machinery involves two partners: the Ku protein, a DNA end b

Externí odkaz: https://doaj.org/article/030ad7bb50254d7fb64f23be6ce1dde9

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Akademický článek

Identification of new genes contributing to the extreme radioresistance of Deinococcus radiodurans using a Tn5-based transposon mutant library.

Autor: Rémi Dulermo, Takefumi Onodera, Geneviève Coste, Fanny Passot, Murielle Dutertre, Martine Porteron, Fabrice Confalonieri, Suzanne Sommer, Cécile Pasternak

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0124358 (2015)

Here, we have developed an extremely efficient in vivo Tn5-based mutagenesis procedure to construct a Deinococcus radiodurans insertion mutant library subsequently screened for sensitivity to genotoxic agents such as γ and UV radiations or mitomycin

Externí odkaz: https://doaj.org/article/3c9ffd09d01e4f089af7fdfc7a7eadca

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Akademický článek

Genome-wide transcriptional response of the archaeon Thermococcus gammatolerans to cadmium.

Autor: Arnaud Lagorce, Aude Fourçans, Murielle Dutertre, Brice Bouyssiere, Yvan Zivanovic, Fabrice Confalonieri

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e41935 (2012)

Thermococcus gammatolerans, the most radioresistant archaeon known to date, is an anaerobic and hyperthermophilic sulfur-reducing organism living in deep-sea hydrothermal vents. Knowledge of mechanisms underlying archaeal metal tolerance in such meta

Externí odkaz: https://doaj.org/article/937167528acd4ac4950acaef78377428

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Structural and functional determinants of the archaeal 8-oxoguanine-DNA glycosylase AGOG for DNA damage recognition and processing

Autor: Franck, Coste, Goffinont, Stéphane, Cros, Julien, Gaudon, Virginie, Martine, Guérin, Garnier, Norbert, Fabrice, Confalonieri, Flament, Didier, Suskiewicz, Marcin Jozef, Bertrand, Castaing

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, 2022, ⟨10.1093/nar/gkac932⟩

International audience; Abstract 8-Oxoguanine (GO) is a major purine oxidation product in DNA. Because of its highly mutagenic properties, GO absolutely must be eliminated from DNA. To do this, aerobic and anaerobic organisms from the three kingdoms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3515::8751cfc874e10ffe5bcc6cd6c1f5b462
https://hal.science/hal-03841526/file/2022_NAR_castaing.pdf

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Structural and functional characterization of DdrC, a novel DNA damage-induced nucleoid associated protein involved in DNA compaction

Autor: Anne-Sophie Banneville, Claire Bouthier de la Tour, Cécilia Hognon, Joanna Timmins, Pascale Servant, Antonio Monari, Jean-Marie Teulon, François Dehez, Aline Le Roy, Jacques-Philippe Colletier, Jean-Luc Pellequer, Fabrice Confalonieri

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, 2022, 50 (13), pp.7680-7696. ⟨10.1093/nar/gkac563⟩

Deinococcus radiodurans is a spherical bacterium well-known for its outstanding resistance to DNA-damaging agents. Exposure to such agents leads to drastic changes in the transcriptome of D. radiodurans. In particular, four Deinococcus-specific genes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8981e72e42e3a1e906fe7fbf42e92462
https://doi.org/10.1101/2021.10.27.466113

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Characterization of the Radiation Desiccation Response Regulon of the Radioresistant Bacterium Deinococcus radiodurans by Integrative Genomic Analyses

Autor: Gaëlle Lelandais, C. Bouthier de la Tour, Esma Bentchikou, Nicolas Eugénie, Yvan Zivanovic, Geneviève Coste, Pascale Servant, Fabrice Confalonieri

Publikováno v: Cells
Cells, 2021, 10 (10), pp.2536. ⟨10.3390/cells10102536⟩
Cells, MDPI, 2021, 10 (10), pp.2536. ⟨10.3390/cells10102536⟩
Volume 10
Issue 10
Cells, Vol 10, Iss 2536, p 2536 (2021)

Numerous genes are overexpressed in the radioresistant bacterium Deinococcus radiodurans after exposure to radiation or prolonged desiccation. The DdrO and IrrE proteins play a major role in regulating the expression of approximately predicted twenty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bae476f7e63b7c4cc304bea582ff178
https://hal.science/hal-03367540/document

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