Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Fabrice Ciesielski"'
Autor:
Meghan H. Murray, Aurore Cecile Valfort, Thomas Koelblen, Céline Ronin, Fabrice Ciesielski, Arindam Chatterjee, Giri Babu Veerakanellore, Bahaa Elgendy, John K. Walker, Lamees Hegazy, Thomas P. Burris
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The nuclear receptor REV-ERBα is a receptor for heme and plays a role in a range of physiological processes. Here, the authors provide the first structure of REV-ERB bound to a synthetic nonporphyrin ligand defining key mechanistic differences to ho
Externí odkaz:
https://doaj.org/article/e9a3baa7b5fa4017822b58a19fb7301d
Autor:
Mariia Radaeva, Huifang Li, Eric LeBlanc, Kush Dalal, Fuqiang Ban, Fabrice Ciesielski, Bonny Chow, Helene Morin, Shannon Awrey, Kriti Singh, Paul S. Rennie, Nada Lallous, Artem Cherkasov
Publikováno v:
Cells, Vol 11, Iss 18, p 2785 (2022)
The mutation-driven transformation of clinical anti-androgen drugs into agonists of the human androgen receptor (AR) represents a major challenge for the treatment of prostate cancer patients. To address this challenge, we have developed a novel clas
Externí odkaz:
https://doaj.org/article/4aa1ebf257e04f9f8d6c4c6190d87376
Autor:
Céline Ronin, David Mendes Costa, Joana Tavares, Joana Faria, Fabrice Ciesielski, Paola Ciapetti, Terry K Smith, Jane MacDougall, Anabela Cordeiro-da-Silva, Iain K Pemberton
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193602 (2018)
The de novo crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1 (LiSir2rp1) has been solved at 1.99Å in complex with an acetyl-lysine peptide substrate. The structure is broadly commensurate with Hst2/SIRT2
Externí odkaz:
https://doaj.org/article/e4b7312a30c44b1bbe495d18d3b04ba1
Autor:
Luís Gaspar, Ross P Coron, Paul KongThoo Lin, David M Costa, Begoña Perez-Cabezas, Joana Tavares, Meritxell Roura-Ferrer, Isbaal Ramos, Céline Ronin, Louise L Major, Fabrice Ciesielski, Iain K Pemberton, Jane MacDougall, Paola Ciapetti, Terry K Smith, Anabela Cordeiro-da-Silva
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006180 (2018)
Chagas disease remains one of the most neglected diseases in the world despite being the most important parasitic disease in Latin America. The characteristic chronic manifestation of chagasic cardiomyopathy is the region's leading cause of heart-rel
Externí odkaz:
https://doaj.org/article/f6e4a1edfb98480288b07d74ed1a4300
Autor:
Tiphaine Huet, Gilles Laverny, Fabrice Ciesielski, Ferdinand Molnár, Thanuja Gali Ramamoorthy, Anna Y. Belorusova, Pierre Antony, Noelle Potier, Daniel Metzger, Dino Moras, Natacha Rochel
Publikováno v:
Cell Reports, Vol 10, Iss 4, Pp 516-526 (2015)
The bioactive form of vitamin D [1,25(OH)2D3] regulates mineral and bone homeostasis and exerts potent anti-inflammatory and antiproliferative properties through binding to the vitamin D receptor (VDR). The 3D structures of the VDR ligand-binding dom
Externí odkaz:
https://doaj.org/article/c1ca4632498449e98f431812cd05e383
Autor:
Anabela Cordeiro-da-Silva, Louise L. Major, Mónica Sá, Paola Ciapetti, Jane MacDougall, Terry K. Smith, Fabrice Ciesielski, Joana Tavares, Nuno Santarém, Nathalie Trouche, Emily A. Dickie, Iain K. Pemberton, Céline Ronin
Publikováno v:
Antimicrob Agents Chemother
Funding from the European Community's Seventh Framework Programme under grant agreements No. 602773 (Project KINDRED) was received for all partners in this work. This work also received funds from FCT - Fundação para a Ciência e a Tecnologia/Minis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03593d13f339e842adf9b91dc2d37197
https://hdl.handle.net/10023/24164
https://hdl.handle.net/10023/24164
Autor:
Cédric Atmanene, Céline Ronin, Valérie Vivat, Fabrice Ciesielski, François-Moana Gautier, Florence Djedaïni-Pilard, Stéphane Téletchéa, Cyrille Grandjean
Publikováno v:
Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, Elsevier, 2017, 489 (3), pp.281-286. ⟨10.1016/j.bbrc.2017.05.150⟩
Biochemical and Biophysical Research Communications, Elsevier, 2017, 489 (3), pp.281-286. ⟨10.1016/j.bbrc.2017.05.150⟩
Combination of biophysical and structural techniques allowed characterizing and uncovering the mechanisms underlying increased binding affinity of lactosamine derivatives for galectin 3. In particular, complementing information gathered from X-ray cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b173e163e5e350d58d3379788bdcf000
https://doi.org/10.1016/j.bbrc.2017.05.150
https://doi.org/10.1016/j.bbrc.2017.05.150
Autor:
Romain Pierre, Etienne Thoreau, Catherine Raffin, Claire Bouix-Peter, Laurent Chantalat, Gaëlle Polge, Jonathan Pascau, Gilles Ouvry, Nathalie Taquet, Catherine Comino, Denis Duvert, Danielle Orfila, Agnès Perrin, Yves Rival, Laurent Francois Andre Hennequin, Laurent Lamy, Christophe Feret, Branislav Musicki, Veronique Parnet, Anne-Pascale Luzy, Olivier Christin, Fabrice Ciesielski, Craig S. Harris
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5802-5808
Targeting the IL17 pathway and more specifically the nuclear receptor RORγ is thought to be beneficial in multiple skin disorders. The Letter describes the discovery of phenoxyindazoles and thiophenoxy indazoles as potent RORγ inverse agonists. Opt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af63284f22f668869fc68a5936ba38ec
https://doi.org/10.1016/j.bmcl.2016.10.023
https://doi.org/10.1016/j.bmcl.2016.10.023
Autor:
Ferdinand Molnár, Noelle Potier, Fabrice Ciesielski, Pierre Antony, Gilles Laverny, Daniel Metzger, Anna Y. Belorusova, Thanuja Gali Ramamoorthy, Natacha Rochel, Dino Moras, Tiphaine Huet
Publikováno v:
Cell Reports
Cell Reports, Elsevier Inc, 2015, 10 (4), pp.516-526. ⟨10.1016/j.celrep.2014.12.045⟩
Cell Reports, Vol 10, Iss 4, Pp 516-526 (2015)
Cell Reports, Elsevier Inc, 2015, 10 (4), pp.516-526. ⟨10.1016/j.celrep.2014.12.045⟩
Cell Reports, Vol 10, Iss 4, Pp 516-526 (2015)
Summary The bioactive form of vitamin D [1,25(OH) 2 D 3 ] regulates mineral and bone homeostasis and exerts potent anti-inflammatory and antiproliferative properties through binding to the vitamin D receptor (VDR). The 3D structures of the VDR ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59668a4739c2097bb989497f1a37d9ed
Autor:
R Galien, Raphael Geney, Koen Kurt Smits, Béatrice Vayssière, Thierry Christophe, Reginald Brys, L. Lepescheux, Ellen van der Aar, Luc Nelles, Fabrice Ciesielski, Guy Van Lommen, Pierre Deprez, Luc Juliaan Corina Van Rompaey, Muriel Uhring, Stephen Robert Fletcher, Christel Jeanne Marie Menet, Philippe Clément-Lacroix, Javier Blanc, Nolwenn Jouannigot
Publikováno v:
Journal of Medicinal Chemistry. 57:9323-9342
Janus kinases (JAK1, JAK2, JAK3, and TYK2) are involved in the signaling of multiple cytokines important in cellular function. Blockade of the JAK-STAT pathway with a small molecule has been shown to provide therapeutic immunomodulation. Having ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9517bf576a1a79fdee93942c785e39bf
https://doi.org/10.1021/jm501262q
https://doi.org/10.1021/jm501262q