In vivo expansion of naive and activated CD4 + CD25 + FOXP3 + regulatory T cell populations in interleukin-2–treated HIV patients

Autor: Matthieu Carrière, Brice Targat, Arndt Benecke, Lars Rogge, Laurence Weiss, Sylvie Maiella, Vladimira Donkova-Petrini, Yves Levy, Fabrice A. Letimier

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2010, 107 (23), pp.10632-7. ⟨10.1073/pnas.1000027107⟩
Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (23), pp.10632-7. ⟨10.1073/pnas.1000027107⟩

HIV-1 infection is characterized by a progressive decline in CD4 + T cells leading to a state of profound immunodeficiency. IL-2 therapy has been shown to improve CD4 + counts beyond that observed with antiretroviral therapy. Recent phase III trials

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507ac73220beaf82fe43fddca402cb32
https://doi.org/10.1073/pnas.1000027107

Chromatin remodeling by the SWI/SNF-like BAF complex and STAT4 activation synergistically induce IL-12Rbeta2 expression during human Th1 cell differentiation

Autor: Elisabetta Bianchi, Sona Gasparian, Lars Rogge, Nadia Passini, Fabrice A. Letimier

Publikováno v: EMBO Journal
EMBO Journal, EMBO Press, 2007, 26 (5), pp.1292-1302. ⟨10.1038/sj.emboj.7601586⟩
EMBO Journal, 2007, 26 (5), pp.1292-1302. ⟨10.1038/sj.emboj.7601586⟩

Interleukin-12 (IL-12) is a key cytokine for the development of T helper type 1 (Th1) responses; however, naive CD4(+) T cells do not express IL-12Rbeta2, and are therefore unresponsive to IL-12. We have examined the mechanisms that control Th1-speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c925545b352aa9a0d909a84330cea497
https://hal-pasteur.archives-ouvertes.fr/pasteur-00161615