Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Fabrice, Agou"'
Generation of IPi002-A/B/C human induced pluripotent stem cell lines from MARCH amniotic fluid cells
Autor:
Mikaël Boullé, Ambre Leleu, Siham Schacre, Céline Banal, Alix Boucharlat, Solène Renault, Marcel Hollenstein, Patrick Frosk, Frank Yates, Nathalie Lefort, Fabrice Agou
Publikováno v:
Stem Cell Research, Vol 81, Iss , Pp 103589- (2024)
Human induced pluripotent stem cells (hiPSCs) have become a revolutionary tool in biomedical research due to their unique in vitro properties and fate versatility. They offer insights into development or genetic disorders, facilitate drug discovery a
Externí odkaz:
https://doaj.org/article/76715fe9ab014419842cc738eef767a4
Autor:
Suman Khan, Efrat Ozer Partuk, Jeanne Chiaravalli, Noga Kozer, Khriesto A. Shurrush, Yael Elbaz-Alon, Nadav Scher, Emilie Giraud, Jaouen Tran-Rajau, Fabrice Agou, Haim Michael Barr, Ori Avinoam
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110019- (2024)
Summary: The COVID-19 pandemic highlighted the need for antivirals against emerging coronaviruses (CoV). Inhibiting spike (S) glycoprotein-mediated viral entry is a promising strategy. To identify small molecule inhibitors that block entry downstream
Externí odkaz:
https://doaj.org/article/4c9b2fc3517e4041840a3771ac2a2f91
Autor:
Francisco J. Martinez, Michael White, Micheline Guillotte-Blisnick, Christèle Huon, Alix Boucharlat, Fabrice Agou, Patrick England, Jean Popovici, Mimi M. Hou, Sarah E. Silk, Jordan R. Barrett, Carolyn M. Nielsen, Jenny M. Reimer, Paushali Mukherjee, Virander S. Chauhan, Angela M. Minassian, Simon J. Draper, Chetan E. Chitnis
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-11 (2024)
Abstract The receptor-binding domain, region II, of the Plasmodium vivax Duffy binding protein (PvDBPII) binds the Duffy antigen on the reticulocyte surface to mediate invasion. A heterologous vaccine challenge trial recently showed that a delayed do
Externí odkaz:
https://doaj.org/article/4ef9c0cbceda4b979429052cf23a7f55
Autor:
Mikaël Boullé, Alix Boucharlat, Ambre Leleu, Céline Banal, Aurélie Coussement, Marcel Hollenstein, Frank Yates, Nathalie Lefort, Fabrice Agou
Publikováno v:
Stem Cell Research, Vol 76, Iss , Pp 103350- (2024)
Human induced Pluripotent Stem Cells (hiPSCs) represent an invaluable source of primary cells to investigate development, establish cell and disease models, provide material for regenerative medicine and allow more physiological high-content screenin
Externí odkaz:
https://doaj.org/article/670abe90fddf4373896cf392088b9aec
Autor:
Franck Touret, Emilie Giraud, Jérôme Bourret, Flora Donati, Jaouen Tran-Rajau, Jeanne Chiaravalli, Frédéric Lemoine, Fabrice Agou, Etienne Simon-Lorière, Sylvie van der Werf, Xavier de Lamballerie
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106413- (2023)
Summary: The landscape of SARS-CoV-2 variants dramatically diversified with the simultaneous appearance of multiple subvariants originating from BA.2, BA.4, and BA.5 Omicron sub-lineages. They harbor a specific set of mutations in the spike that can
Externí odkaz:
https://doaj.org/article/1bbb298c8e25422ebe9435705eccb535
Autor:
Bjoern Meyer, Jeanne Chiaravalli, Stacy Gellenoncourt, Philip Brownridge, Dominic P. Bryne, Leonard A. Daly, Arturas Grauslys, Marius Walter, Fabrice Agou, Lisa A. Chakrabarti, Charles S. Craik, Claire E. Eyers, Patrick A. Eyers, Yann Gambin, Andrew R. Jones, Emma Sierecki, Eric Verdin, Marco Vignuzzi, Edward Emmott
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
During SARS-CoV-2 replication, viral and cellular proteases play crucial roles and have been shown to be promising anti-viral targets. Here, Meyer et al. apply mass spectrometry to characterize the proteolytic cleavage profile of viral and cellular p
Externí odkaz:
https://doaj.org/article/09cd9fa5dad54609b514710cffa2869d
Autor:
Mikaël Boullé, Laurianne Davignon, Keïs Nabhane Saïd Halidi, Salomé Guez, Emilie Giraud, Marcel Hollenstein, Fabrice Agou
Publikováno v:
Cells, Vol 11, Iss 23, p 3862 (2022)
CEP55 is a central regulator of late cytokinesis and is overexpressed in numerous cancers. Its post-translationally controlled recruitment to the midbody is crucial to the structural coordination of the abscission sequence. Our recent evidence that C
Externí odkaz:
https://doaj.org/article/a4a2442309c844fd9690b9d3c13d989b
Autor:
Keïs Nabhane Said Halidi, Elisabeth Fontan, Alix Boucharlat, Laurianne Davignon, Marine Charpentier, Mikaël Boullé, Robert Weil, Alain Israël, Emmanuel Laplantine, Fabrice Agou
Publikováno v:
iScience, Vol 20, Iss , Pp 292-309 (2019)
Summary: CEP55 regulates the final critical step of cell division termed cytokinetic abscission. We report herein that CEP55 contains two NEMO-like ubiquitin-binding domains (UBDs), NOA and ZF, which regulate its function in a different manner. In vi
Externí odkaz:
https://doaj.org/article/43528c8ba79d41b8a1bd87154ceacfe4
Autor:
Haitham Hassan, Jeanne Chiavaralli, Afnan Hassan, Loay Bedda, Tim Krischuns, Kuang-Yu Chen, Alice Shi Ming Li, Adrien Delpal, Etienne Decroly, Masoud Vedadi, Nadia Naffakh, Fabrice Agou, Sergio Mallart, Reem K. Arafa, Paola B. Arimondo
Publikováno v:
RSC Medicinal Chemistry
RSC Medicinal Chemistry, 2023, 14 (3), pp.507-519. ⟨10.1039/D2MD00149G⟩
RSC Medicinal Chemistry, 2023, 14 (3), pp.507-519. ⟨10.1039/D2MD00149G⟩
International audience; A naturally inspired chemical library of 25 molecules was synthesised guided by 3-D dimensionality and natural product likeness proved to have antiviral activity against SARS-CoV-2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5483d205d7cab1f6dc019ca38deac4e
https://doi.org/10.1039/d2md00149g
https://doi.org/10.1039/d2md00149g
Autor:
Janine Scholefield, Ricardo Henriques, Anca F. Savulescu, Elisabeth Fontan, Alix Boucharlat, Emmanuel Laplantine, Asma Smahi, Alain Israël, Fabrice Agou, Musa M. Mhlanga
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
NEMO is a member of the IKK complex that binds ubiquitin, involved in NF-κB signalling and proposed to form higher order structures. Here the authors use super-resolution microscopy to detect the presence of NEMO lattices in cells, that are modified
Externí odkaz:
https://doaj.org/article/bf1e75c472b84f6aaf2453cc4cab9d72