Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Fabiola Puentes"'
Autor:
Fabiola Puentes, Vittoria Lombardi, Ching‐Hua Lu, Ozlem Yildiz, Pietro Fratta, Adrian Isaacs, Yoana Bobeva, Joanne Wuu, ALS Biomarker Consortium, CReATe Consortium, Michael Benatar, Andrea Malaspina
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 9, Pp 1831-1844 (2021)
Abstract Objective To appraise the utility as biomarkers of blood antibodies and immune complexes to neurofilaments and dipeptide repeat proteins, the products of translation of the most common genetic mutation in amyotrophic lateral sclerosis (ALS).
Externí odkaz:
https://doaj.org/article/831d47c10edf428f8b511cafea05761e
Publikováno v:
BMJ Neurology Open, Vol 3, Iss 2 (2021)
Background and objective The concentration of neurofilament light (NfL) protein in cerebrospinal fluid (CSF) and blood is widely considered as a quantitative measure of neuro-axonal injury. Immune reactivity to NfL released into extracellular fluids
Externí odkaz:
https://doaj.org/article/cdd6a9370b6d48f7aaa21e0d359882c0
Autor:
José Arturo Gutiérrez, Fabiola Puentes, Alberto Moreno, Manuel Elkin Patarroyo, Luis Angel Murillo
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 96, Iss 6, Pp 835-838 (2001)
Differential display technique was applied in order to identify transcripts which are present in axenic amastigotes but not in promastigotes of the Leishmania panamensis parasites. One of them was cloned and the sequence reveals an open reading frame
Externí odkaz:
https://doaj.org/article/1356b5af11b9490095bd12260be4cb3c
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64888 (2013)
BACKGROUND: Autoimmune diseases result from a breakdown in self-tolerance to autoantigens. Self-tolerance is induced and sustained by central and peripheral mechanisms intended to deviate harmful immune responses and to maintain homeostasis, where re
Externí odkaz:
https://doaj.org/article/d49dabd4d7b849028d5cb3f318e0d891
Publikováno v:
Clinical and Experimental Immunology
Amor, S, Nutma, E, Marzin, M & Puentes, F 2021, ' Imaging immunological processes from blood to brain in amyotrophic lateral sclerosis ', Clinical and Experimental Immunology, vol. 206, no. 3, pp. 301-313 . https://doi.org/10.1111/cei.13660
Amor, S, Nutma, E, Marzin, M & Puentes, F 2021, ' Imaging immunological processes from blood to brain in amyotrophic lateral sclerosis ', Clinical and Experimental Immunology, vol. 206, no. 3, pp. 301-313 . https://doi.org/10.1111/cei.13660
Neuropathology studies of amyotrophic lateral sclerosis (ALS) and animal models of ALS reveal a strong association between aberrant protein accumulation and motor neurone damage, as well as activated microglia and astrocytes. While the role of neuroi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ad5524e21006917d2b7886efcd25e19
https://doi.org/10.1111/cei.13660
https://doi.org/10.1111/cei.13660
Autor:
Denise Sheer, Andrea Malaspina, Fabiola Puentes, Irene Zubiri, Ian Pike, Simon McArthur, Rocco Adiutori, Michael Bremang, Emanuela Leoni, Vittoria Lombardi, Johan Aarum
Publikováno v:
Brain Communications
Plasma proteome composition reflects the inflammatory and metabolic state of the organism and can be predictive of system-level and organ-specific pathologies. Circulating protein aggregates are enriched with neurofilament heavy chain—axonal protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b87e2f735998cf0593e79fe32e6aece
https://doi.org/10.1093/braincomms/fcab148
https://doi.org/10.1093/braincomms/fcab148
Autor:
Andrea Malaspina, Rocco Adiutori, Johan Aarum, Denise Sheer, Irene Zubiri, Emanuela Leoni, Michael Bremang, Vittoria Lombardi, Simon McArthur, Ian Pike, Fabiola Puentes
Background: plasma proteins composition reflects the inflammatory and metabolic state of an organism and can be predictive of system-level and organ-specific pathologies. Circulating protein aggregates (CPA) are enriched with heavy chain neurofilamen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee4029f6514a42e4c0042cd8b20364f
https://doi.org/10.21203/rs.3.rs-71596/v1
https://doi.org/10.21203/rs.3.rs-71596/v1
Autor:
Özlem Yildiz, Ahuva Nissim, Yoana Bobeva, Andrea Malaspina, Pietro Fratta, Fabiola Puentes, Adrian M. Isaacs, Angray S. Kang, Ching-Hua Lu, Vittoria Lombardi
ObjectiveTo test antibody response and formation of immune-complexes to neurofilaments and dipeptide-repeats, the translational products of the mutated C9orf72 gene, as potential biomarkers for clinical stratification of amyotrophic lateral sclerosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f9fcc0382a20a7de1a74eeb0cf12e4
https://doi.org/10.1101/2020.02.25.965236
https://doi.org/10.1101/2020.02.25.965236
Publikováno v:
Brain Pathology. 26:248-257
Neurological dysfunction and motor neuron degeneration in amyotrophic lateral sclerosis (ALS) is strongly associated with neuroinflammation reflected by activated microglia and astrocytes in the CNS. In ALS endogenous triggers in the CNS such as aggr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46e9055962660b11b69f6f19740d5d76
https://doi.org/10.1111/bpa.12352
https://doi.org/10.1111/bpa.12352
Autor:
Stephanie D. Boomkamp, Paul van der Valk, Susan C. Barnett, Isabel Bosca, Jodie Stephenson, Louis Boon, Sandra Amor, David Baker, Sharmilee Gnanapavan, Markus Kipp, Fabiola Puentes, Joel Raffel, Baukje J. van der Star
Publikováno v:
Immunology
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Puentes, F, van der Star, B J, Boomkamp, S D, Kipp, M, Boon, L, Bosca, I, Raffel, J, Gnanapavan, S, van der Valk, P, Stephenson, J, Barnett, S C, Baker, D & Amor, S 2017, ' Neurofilament light as an immune target for pathogenic antibodies ', Immunology, vol. 152, no. 4, pp. 580-588 . https://doi.org/10.1111/imm.12797
Immunology, 152(4), 580-588. Wiley-Blackwell
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Puentes, F, van der Star, B J, Boomkamp, S D, Kipp, M, Boon, L, Bosca, I, Raffel, J, Gnanapavan, S, van der Valk, P, Stephenson, J, Barnett, S C, Baker, D & Amor, S 2017, ' Neurofilament light as an immune target for pathogenic antibodies ', Immunology, vol. 152, no. 4, pp. 580-588 . https://doi.org/10.1111/imm.12797
Immunology, 152(4), 580-588. Wiley-Blackwell
Antibodies to neuronal antigens are associated with many neurological diseases including paraneoplastic neurological disorders, epilepsy, amyotrophic lateral sclerosis and multiple sclerosis. Immunization with neuronal antigens such as neurofilament
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f21bfbe7e5e8089f485595838f269b
http://hdl.handle.net/10379/13531
http://hdl.handle.net/10379/13531