Structural and biochemical insights of CypA and AIF interaction

Autor: Biancamaria Farina, Gianluigi Di Sorbo, Angela Chambery, Andrea Caporale, Guido Leoni, Rosita Russo, Fabiola Mascanzoni, Domenico Raimondo, Roberto Fattorusso, Menotti Ruvo, Nunzianna Doti

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Abstract The Cyclophilin A (CypA)/Apoptosis Inducing Factor (AIF) complex is implicated in the DNA degradation in response to various cellular stress conditions, such as oxidative stress, cerebral hypoxia-ischemia and traumatic brain injury. The pro-

Externí odkaz: https://doaj.org/article/a91821b2950a40689864374c11113d44

The Golgi checkpoint: Golgi unlinking during G2 is required for correct spindle formation and cytokinesis

Autor: Fabiola Mascanzoni, Inmaculada Ayala, Roberta Iannitti, Alberto Luini, Antonino Colanzi

The decision to enter mitosis requires not only the control of DNA replication but also additional and crucial preparatory steps such as, for example, partial disassembly of the Golgi complex during G2. The Golgi complex is fundamental for the proces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6674c960d412db52cd2cbb5786c8d309
https://doi.org/10.1101/2023.03.05.531163

Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to Inhibit Apoptosis Inducing Factor-Mediated Cell Death

Autor: Biancamaria Farina, Carsten Culmsee, Amalia Mihaela Dolga, Luigi Russo, Menotti Ruvo, Nunzianna Doti, Roberto Fattorusso, Fabiola Mascanzoni, Alessandra Monti, Andrea Caporale

Publikováno v: Journal of Medicinal Chemistry, 64(15), 11445-11459. AMER CHEMICAL SOC

Blocking the interaction between the apoptosis-inducing factor (AIF) and cyclophilin A (CypA) by the AIF fragment AIF(370-394) is protective against glutamate-induced neuronal cell death and brain injury in mice. Starting from AIF(370-394), we report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8753f90236e54cb76eea53ccd197d5e8
https://research.rug.nl/en/publications/04f3e107-9064-406a-8ac0-abfc6105b17f

Binding mode of AIF(370–394) peptide to CypA: insights from NMR, label-free and molecular docking studies

Autor: Mattia Sturlese, Andrea Caporale, Menotti Ruvo, Alessandra Monti, Nunzianna Doti, Fabiola Mascanzoni, Gianluigi Di Sorbo, Roberto Fattorusso, Biancamaria Farina

Publikováno v: Biochemical Journal. 475:2377-2393

The complex formation between the proteins apoptosis-inducing factor (AIF) and cyclophilin A (CypA) following oxidative stress in neuronal cells has been suggested as a main target for reverting ischemia-stroke damage. Recently, a peptide encompassin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64502d5a00b756961af5c693c05f5eac
https://doi.org/10.1042/bcj20180177

Organelle Inheritance Control of Mitotic Entry and Progression: Implications for Tissue Homeostasis and Disease

Autor: Antonino Colanzi, Fabiola Mascanzoni, Inmaculada Ayala

Publikováno v: Frontiers in Cell and Developmental Biology (2019). doi:10.3389/fcell.2019.00133
info:cnr-pdr/source/autori:Mascanzoni F, Ayala I, Colanzi A/titolo:Organelle Inheritance Control of Mitotic Entry and Progression: Implications for Tissue Homeostasis and Disease./doi:10.3389%2Ffcell.2019.00133/rivista:Frontiers in Cell and Developmental Biology/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Frontiers in Cell and Developmental Biology

The Golgi complex (GC), in addition to its well-known role in membrane traffic, is also actively involved in the regulation of mitotic entry and progression. In particular, during the G2 phase of the cell cycle, the Golgi ribbon is unlinked into isol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f94f392b2e27156c424248fae49405