Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Fabiola E. Medina"'
Publikováno v:
Journal of Chemical Information and Modeling. 63:270-280
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a5c100ba4ffa4b8ffce05aa78c737e2
https://doi.org/10.1021/acs.jcim.2c01122
https://doi.org/10.1021/acs.jcim.2c01122
Autor:
Fabiola E. Medina, Gonzalo Jaña
Publikováno v:
ACS Catalysis. 12:36-47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae61e247bc69ad3754e75f1e6ae446e8
https://doi.org/10.1021/acscatal.1c04786
https://doi.org/10.1021/acscatal.1c04786
Autor:
Leslie, Sánchez, Fabiola E, Medina, Fernanda, Mendoza, Camilo, Febres-Molina, Gonzalo A, Jaña
Publikováno v:
Journal of chemical information and modeling.
The l-asparaginase (l-ASNase) enzyme catalyzes the conversion of the non-essential amino acid l-asparagine into l-aspartic acid and ammonia. Importantly, the l-ASNases are used as a key part of the treatment of acute lymphoblastic leukemia (ALL); how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1865b9d4eaf725a0af323d02608d71ae
https://pubmed.ncbi.nlm.nih.gov/36469738
https://pubmed.ncbi.nlm.nih.gov/36469738
Autor:
Fabiola E. Medina, João P. M. Sousa, Pedro A. Fernandes, Pedro Ferreira, Matilde F. Viegas, Maria J. Ramos, Pedro Paiva, Rui P. P. Neves
Publikováno v:
Topics in Catalysis. 65:544-562
Polyketide synthases (PKS) produce polyketides, a large group of secondary metabolites produced in bacteria, fungi, plants and certain animal families. PKSs have a huge potential to biosynthesize high-value active pharmaceuticals, agrochemicals, biof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::517927aa305637d35c40f5730777f9bc
https://doi.org/10.1007/s11244-021-01490-5
https://doi.org/10.1007/s11244-021-01490-5
Autor:
Mario Prejanò, Fabiola E. Medina
Publikováno v:
ACS Catalysis. 11:4136-4145
Thiamine diphosphate-dependent enzymes are central to a wide range of technological areas and fields of science. The activity of these enzymes is closely related to the presence of the thiamine dip...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8077f43f80c1293e5936b1cce2d69869
https://doi.org/10.1021/acscatal.0c05414
https://doi.org/10.1021/acscatal.0c05414
Autor:
Fabiola E. Medina, Nino Russo, Mario Prejanò, Pedro A. Fernandes, Maria J. Ramos, Tiziana Marino
Publikováno v:
ACS Catalysis
Atomic resolution X-ray crystallography has shown that an intermediate (the X5P-ThDP adduct) of the catalytic cycle of transketolase (TK) displays a significant, putatively highly energetic, out-of-plane distortion in a sp2 carbon adjacent to a lytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e2da85414b91b6bd567625d7bcb67f
http://europepmc.org/articles/PMC8016368
http://europepmc.org/articles/PMC8016368
Publikováno v:
Journal of Chemical Information and Modeling. 60:915-922
Acetohydroxyacid synthase (AHAS) is a thiamin diphosphate-dependent enzyme involved in the biosynthesis of valine, leucine, isoleucine, and lysine. Experimental evidence has shown that mutation of the Gln202 residue results in a decrease in the enzym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::859a474410162403ede4322cac4d854a
https://doi.org/10.1021/acs.jcim.9b00863
https://doi.org/10.1021/acs.jcim.9b00863
Autor:
Pedro Ferreira, Pedro A. Fernandes, Rui P. P. Neves, Pedro Paiva, Fabiola E. Medina, João P. M. Sousa, Matilde F. Viegas, Maria J. Ramos
Publikováno v:
Chemical reviews. 121(15)
Fatty acids are crucial molecules for most living beings, very well spread and conserved across species. These molecules play a role in energy storage, cell membrane architecture, and cell signaling, the latter through their derivative metabolites. D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a43a24c6ad354f00df4ca39c1145cbd9
https://pubmed.ncbi.nlm.nih.gov/34156235
https://pubmed.ncbi.nlm.nih.gov/34156235
Autor:
María-Soledad Orellana, Gonzalo A. Jaña, Maximiliano Figueroa, José Martínez-Oyanedel, Fabiola E. Medina, Estefanía Tarifeño-Saldivia, Marcell Gatica, María Ángeles García-Robles, Nelson Carvajal, Elena Uribe
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 12; Pages: 6438
Arginase catalyzes the hydrolysis of L-arginine into L-ornithine and urea. This enzyme has several analogies with agmatinase, which catalyzes the hydrolysis of agmatine into putrescine and urea. However, this contrasts with the highlighted specificit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f6e1e9c985496490df1466ed4f0e29
https://doi.org/10.3390/ijms23126438
https://doi.org/10.3390/ijms23126438
Publikováno v:
ACS Catalysis. 8:10267-10278
Dehydratase (DH) is a catalytic domain of the mammalian fatty acid synthase (mFAS), a multidomain enzyme with seven different active sites that work in tandem to carry out the biosynthesis of palmi...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7229220a2a4ac3f1dc297b0940088cdb
https://doi.org/10.1021/acscatal.8b02616
https://doi.org/10.1021/acscatal.8b02616