Výsledky vyhledávání - "Fabiola Blengio"

Akademický článek

Identification of early gene expression profiles associated with long-lasting antibody responses to the Ebola vaccine Ad26.ZEBOV/MVA-BN-Filo

Autor: Fabiola Blengio, Hakim Hocini, Laura Richert, Cécile Lefebvre, Mélany Durand, Boris Hejblum, Pascaline Tisserand, Chelsea McLean, Kerstin Luhn, Rodolphe Thiebaut, Yves Levy

Publikováno v: Cell Reports, Vol 42, Iss 9, Pp 113101- (2023)

Summary: Ebola virus disease is a severe hemorrhagic fever with a high fatality rate. We investigate transcriptome profiles at 3 h, 1 day, and 7 days after vaccination with Ad26.ZEBOV and MVA-BN-Filo. 3 h after Ad26.ZEBOV injection, we observe an inc

Externí odkaz: https://doaj.org/article/5b22ee762b5744dbb4e4be1ccb253909

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Akademický článek

Transcriptome analysis defines myocardium gene signatures in children with ToF and ASD and reveals disease-specific molecular reprogramming in response to surgery with cardiopulmonary bypass

Autor: Federica Raggi, Davide Cangelosi, Pamela Becherini, Fabiola Blengio, Martina Morini, Massimo Acquaviva, Maria Luisa Belli, Giuseppe Panizzon, Giuseppe Cervo, Luigi Varesio, Alessandra Eva, Maria Carla Bosco

Publikováno v: Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-20 (2020)

Abstract Background Tetralogy of Fallot (ToF) and Atrial Septal Defects (ASD) are the most common types of congenital heart diseases and a major cause of childhood morbidity and mortality. Cardiopulmonary bypass (CPB) is used during corrective cardia

Externí odkaz: https://doaj.org/article/975709439062430bb77fbe600bad0735

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Akademický článek

Single-Cell Analysis of Antigen-Specific CD8+ T-Cell Transcripts Reveals Profiles Specific to mRNA or Adjuvanted Protein Vaccines

Autor: Trine Sundebo Meldgaard, Fabiola Blengio, Denise Maffione, Chiara Sammicheli, Simona Tavarini, Sandra Nuti, Roland Kratzer, Duccio Medini, Emilio Siena, Sylvie Bertholet

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

CD8+ T cells play a key role in mediating protective immunity after immune challenges such as infection or vaccination. Several subsets of differentiated CD8+ T cells have been identified, however, a deeper understanding of the molecular mechanism th

Externí odkaz: https://doaj.org/article/df4241590ad64e16bbe15d05e9d0ddea

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Akademický článek

CD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death

Publikováno v: iScience, Vol 24, Iss 7, Pp 102711- (2021)

Summary: The identification of patients with coronavirus disease 2019 and high risk of severe disease is a challenge in routine care. We performed cell phenotypic, serum, and RNA sequencing gene expression analyses in severe hospitalized patients (n

Externí odkaz: https://doaj.org/article/61e089ec34614597aa6b9bb37427c685

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Akademický článek

Hypoxia Modifies the Transcriptome of Human NK Cells, Modulates Their Immunoregulatory Profile, and Influences NK Cell Subset Migration

Autor: Monica Parodi, Federica Raggi, Davide Cangelosi, Claudia Manzini, Mirna Balsamo, Fabiola Blengio, Alessandra Eva, Luigi Varesio, Gabriella Pietra, Lorenzo Moretta, Maria Cristina Mingari, Massimo Vitale, Maria Carla Bosco

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Hypoxia, which characterizes most tumor tissues, can alter the function of different immune cell types, favoring tumor escape mechanisms. In this study, we show that hypoxia profoundly acts on NK cells by influencing their transcriptome, affecting th

Externí odkaz: https://doaj.org/article/d54308ff3cd246158786b7dc3b839f43

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Transcriptome analysis defines myocardium gene signatures in children with ToF and ASD and reveals disease-specific molecular reprogramming in response to surgery with cardiopulmonary bypass

Autor: Massimo Acquaviva, Martina Morini, Davide Cangelosi, Giuseppe Panizzon, Maria Luisa Belli, Maria Carla Bosco, Pamela Becherini, Alessandra Eva, Giuseppe Cervo, Federica Raggi, Fabiola Blengio, Luigi Varesio

Publikováno v: Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-20 (2020)
Journal of Translational Medicine

Background Tetralogy of Fallot (ToF) and Atrial Septal Defects (ASD) are the most common types of congenital heart diseases and a major cause of childhood morbidity and mortality. Cardiopulmonary bypass (CPB) is used during corrective cardiac surgery

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d9e9c385773859bf9feec45a20f1d7
http://hdl.handle.net/2318/1827759

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Hypoxia downregulates the expression of activating receptors involved in NK-cell-mediated target cell killing without affecting ADCC

Autor: Massimo Vitale, Gabriella Pietra, Luigi Varesio, Claudia Manzini, Federica Raggi, Lorenzo Moretta, Mirna Balsamo, Maria Carla Bosco, Fabiola Blengio, Maria Cristina Mingari

Publikováno v: European Journal of Immunology. 43:2756-2764

In certain infection sites or tumor tissues, the disruption of homeostasis can give rise to a hypoxic microenvironment, which, in turn, can alter the function of different immune cell types and favor the progression of the disease. Natural killer (NK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1349ba88ec3dacb690fe3f0ab4f04605
https://doi.org/10.1002/eji.201343448

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Chronic hypoxia reprograms human immature dendritic cells by inducing a proinflammatory phenotype and TREM-1 expression

Autor: Paola Cappello, Mirella Giovarelli, Miriam Filippi, Tiziana Musso, Alessandra Eva, Maria Carla Bosco, Federica Raggi, Fabiola Blengio, Daniele Pierobon, Francesco Novelli, Luigi Varesio

Publikováno v: European Journal of Immunology. 43:949-966

DCs are powerful antigen-presenting cells central in the orchestration of innate and acquired immunity. DC development, migration, and activities are intrinsically linked to the microenvironment. DCs migrate through pathologic tissues before reaching

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f87104c5b4cbda8591798397838fd031
https://doi.org/10.1002/eji.201242709

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