The Protein Targeting Factor Get3 Functions as ATP-Independent Chaperone under Oxidative Stress Conditions

Autor: Fabio Vilardi, Daniel R. Southworth, Sheng Li, Markus Schick, Blanche Schwappach, Irina Gostimskaya, Stephanie N. Gates, Wilhelm Voth, Ursula Jakob

Publikováno v: Molecular Cell
Molecular cell, vol 56, iss 1

SUMMARY Exposure of cells to reactive oxygen species (ROS) causes a rapid and significant drop in intracellular ATP levels. This energy depletion negatively affects ATP-dependent chaperone systems, making ROSmediated protein unfolding and aggregation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8402861f357314e61dd71f1f185751f8

Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing

Autor: Artur A. Indzhykulian, Tobias Moser, Thomas Weber, David P. Corey, Xudong Wu, Elena Cardenas, Ignacio del Castillo, Rosamaria Santarelli, Kelvin Y. Kwan, Iliana Panou, Montserrat Rodríguez-Ballesteros, Carolin Wichmann, Sonja M. Wojcik, SangYong Jung, Christian Vogl, Fabio Vilardi, Shuh-Yow Lin, Gulnara Yamanbaeva, Blanche Schwappach, Nicola Strenzke, Sara J Mangosing, Tina Pangršič

Publikováno v: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
The EMBO Journal

The transmembrane recognition complex (TRC40) pathway mediates the insertion of tail‐anchored (TA) proteins into membranes. Here, we demonstrate that otoferlin, a TA protein essential for hair cell exocytosis, is inserted into the endoplasmic retic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4632b151b611e64d42ee531c07c5e3
https://hdl.handle.net/20.500.12530/25768

WRB is the receptor for TRC40/Asna1-mediated insertion of tail-anchored proteins into the ER membrane

Autor: Bernhard Dobberstein, Holger Lorenz, Fabio Vilardi

Publikováno v: Journal of Cell Science

Tail-anchored (TA) proteins are post-translationally targeted to and inserted into the endoplasmic reticulum (ER) membrane through their single C-terminal transmembrane domain. Membrane insertion of TA proteins in mammalian cells is mediated by the A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425618498ed10ad96e46554cb72127de
http://europepmc.org/articles/PMC3115773

Structural insights into tail-anchored protein binding and membrane insertion by Get3

Autor: Goran Stjepanovic, Stefan Amlacher, Irmgard Sinning, Gert Bange, Fabio Vilardi, Vincenzo Favaloro, Karsten Rippe, Bernhard Dobberstein, Ed Hurt, Klemens Wild, Gunes Bozkurt

Publikováno v: Proceedings of the National Academy of Sciences. 106:21131-21136

Tail-anchored (TA) membrane proteins are involved in a variety of important cellular functions, including membrane fusion, protein translocation, and apoptosis. The ATPase Get3 (Asna1, TRC40) was identified recently as the endoplasmic reticulum targe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0edd1e4687126af3628ca607b8dc814c
https://doi.org/10.1073/pnas.0910223106

EBV Protein BNLF2a Exploits Host Tail-Anchored Protein Integration Machinery To Inhibit TAP

Autor: Hans C. van Leeuwen, Catherine Rabu, Daniëlle Horst, Bernhard Dobberstein, Fabio Vilardi, Maaike E. Ressing, Malgorzata A. Garstka, Alan B. Rickinson, Vincenzo Favaloro, Stephen High, Andrew D. Hislop, Elisabeth Kremmer, Emmanuel J. H. J. Wiertz

Publikováno v: Journal of Immunology, 186(6), 3594-3605
J. Immunol. 186, 3594-3605 (2011)

EBV, the prototypic human γ1-herpesvirus, persists for life in infected individuals, despite the presence of vigorous antiviral immunity. CTLs play an important role in the protection against viral infections, which they detect through recognition o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c56458c415354b49787f3838f72a439
https://hdl.handle.net/1887/111277