Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Fabio Stossi"'
Autor:
Grace O. Adeniyi-Ipadeola, Julia D. Hankins, Amal Kambal, Xi-Lei Zeng, Ketki Patil, Victoria Poplaski, Carolyn Bomidi, Hoa Nguyen-Phuc, Sandra L. Grimm, Cristian Coarfa, Fabio Stossi, Sue E. Crawford, Sarah E. Blutt, Allison L. Speer, Mary K. Estes, Sasirekha Ramani
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT Human intestinal enteroids (HIEs) are gaining recognition as physiologically relevant models of the intestinal epithelium. While HIEs from adults are used extensively in biomedical research, few studies have used HIEs from infants. Consideri
Externí odkaz:
https://doaj.org/article/21fddf0cda974e5890184c60894d739a
Autor:
Michael J. Bolt, Jessica Oceguera, Pankaj K. Singh, Kazem Safari, Derek H. Abbott, Kaley A. Neugebauer, Maureen G. Mancini, Daniel A. Gorelick, Fabio Stossi, Michael A. Mancini
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109275- (2024)
Summary: The initial step in estrogen-regulated transcription is the binding of a ligand to its cognate receptors, named estrogen receptors (ERα and ERβ). Phytochemicals present in foods and environment can compete with endogenous hormones to alter
Externí odkaz:
https://doaj.org/article/f27ba319ca7e4cc1b5641920f2a19da6
Autor:
Derek A. Abbott, Maureen G. Mancini, Michael J. Bolt, Adam T. Szafran, Kaley A. Neugebauer, Fabio Stossi, Daniel A. Gorelick, Michael A. Mancini
Publikováno v:
Heliyon, Vol 10, Iss 1, Pp e23119- (2024)
In this study we present an inducible biosensor model for the Estrogen Receptor Beta (ERβ), GFP-ERβ:PRL-HeLa, a single-cell-based high throughput (HT) in vitro assay that allows direct visualization and measurement of GFP-tagged ERβ binding to ER-
Externí odkaz:
https://doaj.org/article/72f160106c83423bac993c7ba9428a4b
Autor:
Renata Mendonça Moraes, Maíra Terra Garcia, Fabio Stossi, Patrícia Pimentel de Barros, Juliana Campos Junqueira, Ana Lia Anbinder
Publikováno v:
Virulence, Vol 13, Iss 1, Pp 1614-1630 (2022)
To investigate the role of adrenergic signalling (AS) in the host immune response and Porphyromonas gingivalis virulence, we compared norepinephrine (NE) and isoproterenol (ISO) responses in Galleria mellonella. P. gingivalis infection was evaluated
Externí odkaz:
https://doaj.org/article/bfb2a211d64940169dce1942d8daf4db
Autor:
Tattym E. Shaiken, Sandra L. Grimm, Mohamad Siam, Amanda Williams, Abdol-Hossein Rezaeian, Daniel Kraushaar, Emily Ricco, Matthew J. Robertson, Cristian Coarfa, Antrix Jain, Anna Malovannaya, Fabio Stossi, Antone R. Opekun, Alyssa P. Price, Julien Dubrulle
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105965- (2023)
Summary: Despite the knowledge that protein translation and various metabolic reactions that create and sustain cellular life occur in the cytoplasm, the structural organization within the cytoplasm remains unclear. Recent models indicate that cytopl
Externí odkaz:
https://doaj.org/article/f9e71643635c4025b44b5b347560559c
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105200- (2022)
Summary: The United States Environmental Protection Agency (EPA) has been pursuing new high throughput in vitro assays to characterize endocrine disrupting chemicals (EDCs) that interact with estrogen receptor signaling. We characterize two new PRL-H
Externí odkaz:
https://doaj.org/article/9e5eeb02d01246dca186bc7f6ecadcb7
Autor:
Na Zhao, Reid T. Powell, Xueying Yuan, Goeun Bae, Kevin P. Roarty, Fabio Stossi, Martina Strempfl, Michael J. Toneff, Hannah L. Johnson, Sendurai A. Mani, Philip Jones, Clifford C. Stephan, Jeffrey M. Rosen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The epithelial-mesenchymal transition (EMT) has been implicated in stem cell properties and therapeutic resistance in cancer. Here, the authors show organoids derived from mesenchymal breast cancers exhibit a spikey structure which can be reverted an
Externí odkaz:
https://doaj.org/article/4bf1f86424d4458c89d66da69cca86c8
Autor:
Anubama Rajan, Ashley Morgan Weaver, Gina Marie Aloisio, Joseph Jelinski, Hannah L. Johnson, Susan F. Venable, Trevor McBride, Letisha Aideyan, Felipe-Andrés Piedra, Xunyan Ye, Ernestina Melicoff-Portillo, Malli Rama Kanthi Yerramilli, Xi-Lei Zeng, Michael A. Mancini, Fabio Stossi, Anthony W. Maresso, Shalaka A. Kotkar, Mary K. Estes, Sarah Blutt, Vasanthi Avadhanula, Pedro A. Piedra
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT There is an unmet need for preclinical models to understand the pathogenesis of human respiratory viruses and predict responsiveness to immunotherapies. Airway organoids can serve as an ex vivo human airway model to study respiratory viral p
Externí odkaz:
https://doaj.org/article/d19e06d3907d4ae0a97b769078363018
Autor:
Michael J. Bolt, Pankaj Singh, Caroline E. Obkirchner, Reid T. Powell, Maureen G. Mancini, Adam T. Szafran, Fabio Stossi, Michael A. Mancini
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103227- (2021)
Summary: Transcription is a highly regulated sequence of stochastic processes utilizing many regulators, including nuclear receptors (NR) that respond to stimuli. Endocrine disrupting chemicals (EDCs) in the environment can compete with natural ligan
Externí odkaz:
https://doaj.org/article/45c83f8c8620468ca475b94663c889a3
Autor:
Hongbing Liu, Pei-Wen Hu, Julien Dubrulle, Fabio Stossi, Bryan C Nikolai, Michael A Mancini, Andrew P Rice
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0244771 (2021)
Although current antiretroviral therapies (ART) are successful in controlling HIV-1 infection, a stable viral reservoir reactivates when ART is discontinued. Consequently, there is a major research effort to develop approaches to disrupt the latent v
Externí odkaz:
https://doaj.org/article/7239e2932793439baeca3546e1890374