3,3-Disubstituted 3,4-Dihydro-1,2,4-benzotriazines: Chemistry, Biological Activity, and Affinity to Sigma Receptors

Autor: Fabio Sparatore, Anna Sparatore

Publikováno v: Molecules, Vol 29, Iss 1, p 132 (2023)

By reducing the 2-nitrophenylhydrazone of cyclohexanone with sodium dithionite, an unexpected yellow compound was obtained instead of the corresponding colorless amino derivative. Many years later, the structure of this compound, namely, cyclohexane-

Externí odkaz: https://doaj.org/article/e6820b0e4f944018891059169188d5eb

Benzimidazole derivatives endowed with potent antileishmanial activity

Autor: Michele Tonelli, Elena Gabriele, Francesca Piazza, Nicoletta Basilico, Silvia Parapini, Bruno Tasso, Roberta Loddo, Fabio Sparatore, Anna Sparatore

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 210-226 (2018)

Two sets of benzimidazole derivatives were synthesised and tested in vitro for activity against promastigotes of Leishmania tropica and L. infantum. Most of the tested compounds resulted active against both Leishmania species, with IC50 values in the

Externí odkaz: https://doaj.org/article/ae3caed1eed44284ab707d5b717ae1ac

Aromatic Schiff bases and 2,3-disubstituted-1,3-thiazolidin-4-one derivatives as antiinflammatory agents

Autor: Iana Vazzana, Emanuela Terranova, Francesca Mattioli, Fabio Sparatore

Publikováno v: ARKIVOC, Vol 2004, Iss 5, Pp 364-374 (2004)

Externí odkaz: https://doaj.org/article/7f93c998a1444e779941839487966547

Optimization of the clofazimine structure leads to a highly water-soluble C3-aminopyridinyl riminophenazine endowed with improved anti-Wnt and anti-cancer activity in vitro and in vivo

Autor: Alexey Koval a, 1, Ivan Bassanini b, k, Jiabin Xu a, c, Michele Tonelli d, Vito Boido d, Fabio Sparatore d, Frederic Amant e, f, g, Daniela Annibali e, Eleonora Leucci h, i, Anna Sparatore b, 2, Vladimir L. Katanaev a, j

Publikováno v: European journal of medicinal chemistry, 222:113562. Elsevier Masson SAS
European Journal of Medicinal Chemistry, Vol. 222 (2021) P. 113562
European journal of medicinal chemistry 222 (2021). doi:10.1016/j.ejmech.2021.113562
info:cnr-pdr/source/autori:Alexey Koval a, 1, Ivan Bassanini b, k, 1, Jiabin Xu a, c, 1, Michele Tonelli d, Vito Boido d,Fabio Sparatore d, Frederic Amant e, f, g, Daniela Annibali e, Eleonora Leucci h, i, Anna Sparatore b, 2, **, Vladimir L. Katanaev a, j, 2,/titolo:Optimization of the clofazimine structure leads to a highly water-soluble C3-aminopyridinyl riminophenazine endowed with improved anti-Wnt and anti-cancer activity in vitro and in vivo/doi:10.1016%2Fj.ejmech.2021.113562/rivista:European journal of medicinal chemistry/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:222

Triple-negative breast cancer (TNBC) is a cancer subtype critically dependent upon excessive activation of Wnt pathway. The anti-mycobacterial drug clofazimine is an efficient inhibitor of canonical Wnt signaling in TNBC, reducing tumor cell prolifer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4856f758b929c336decae0b21e42f517
https://pure.amc.nl/en/publications/optimization-of-the-clofazimine-structure-leads-to-a-highly-watersoluble-c3aminopyridinyl-riminophenazine-endowed-with-improved-antiwnt-and-anticancer-activity-in-vitro-and-in-vivo(714f018b-0ab1-45e4-a0ee-40f009600f61).html

New arylsparteine derivatives as positive inotropic drugs

Autor: Paola Dorigo, Michele Tonelli, Vito Boido, Marcella Ercoli, Fabio Sparatore, Bruno Tasso, Guglielmina Froldi, Paola Fossa, Federica Novelli, Elena Cichero

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 588-599 (2017)

Positive inotropic agents are fundamental in the treatment of heart failure; however, their arrhythmogenic liability and the increased myocardial oxygen demand strongly limit their therapeutic utility. Pursuing our study on cardiovascular activities

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd801ee69a59b9048aec34b6dffd3963
http://europepmc.org/articles/PMC6009970