Výsledky vyhledávání - "Fabio Simbari"

Akademický článek

Jaspine B induces nonapoptotic cell death in gastric cancer cells independently of its inhibition of ceramide synthase

Autor: Francesca Cingolani, Fabio Simbari, Jose Luis Abad, Mireia Casasampere, Gemma Fabrias, Anthony H. Futerman, Josefina Casas

Publikováno v: Journal of Lipid Research, Vol 58, Iss 8, Pp 1500-1513 (2017)

Sphingolipids (SLs) have been extensively investigated in biomedical research due to their role as bioactive molecules in cells. Here, we describe the effect of a SL analog, jaspine B (JB), a cyclic anhydrophytosphingosine found in marine sponges, on

Externí odkaz: https://doaj.org/article/941fee4dc31a45058d91b6e7b3dc22ce

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Akademický článek

Extracellular Vesicles from a Helminth Parasite Suppress Macrophage Activation and Constitute an Effective Vaccine for Protective Immunity

Autor: Gillian Coakley, Jana L. McCaskill, Jessica G. Borger, Fabio Simbari, Elaine Robertson, Marissa Millar, Yvonne Harcus, Henry J. McSorley, Rick M. Maizels, Amy H. Buck

Publikováno v: Cell Reports, Vol 19, Iss 8, Pp 1545-1557 (2017)

Recent studies have demonstrated that many parasites release extracellular vesicles (EVs), yet little is known about the specific interactions of EVs with immune cells or their functions during infection. We show that EVs secreted by the gastrointest

Externí odkaz: https://doaj.org/article/8bb9b643cf804bdaa9b018beea56deb6

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Akademický článek

Plasmalogen enrichment in exosomes secreted by a nematode parasite versus those derived from its mouse host: implications for exosome stability and biology

Autor: Fabio Simbari, Jana McCaskill, Gillian Coakley, Marissa Millar, Rick M. Maizels, Gemma Fabriás, Josefina Casas, Amy H. Buck

Publikováno v: Journal of Extracellular Vesicles, Vol 5, Iss 0, Pp 1-16 (2016)

Extracellular vesicles (EVs) mediate communication between cells and organisms across all 3 kingdoms of life. Several reports have demonstrated that EVs can transfer molecules between phylogenetically diverse species and can be used by parasites to a

Externí odkaz: https://doaj.org/article/204cfd2686c648059f8cba41d595cba7

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Jaspine B induces nonapoptotic cell death in gastric cancer cells independently of its inhibition of ceramide synthase

Autor: Fabio Simbari, José Luis Abad, Anthony H. Futerman, Francesca Cingolani, Gemma Fabriàs, Mireia Casasampere, Josefina Casas

Publikováno v: Journal of Lipid Research, Vol 58, Iss 8, Pp 1500-1513 (2017)
Digital.CSIC. Repositorio Institucional del CSIC
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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247310c93ee16332816f4ac5001e2086
http://www.sciencedirect.com/science/article/pii/S0022227520337780

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Caveolin-1 Influences LFA-1 Redistribution upon TCR Stimulation in CD8 T Cells

Autor: Liisa M. Uotila, Celine Garcia, Susanna C. Fagerholm, Vicky L. Morrison, Andrew Filby, Jessica G. Borger, Rose Zamoyska, Fabio Simbari

Publikováno v: Borger, J, Morrison, V L, Filby, A, Garcia, C, Uotila, L M, Simbari, F, Fagerholm, S C & Zamoyska, R 2017, ' Caveolin-1 influences LFA-1 redistribution upon TCR stimulation in CD8 T cells ', Journal of Immunology, vol. 199, no. 3, pp. 874-884 . https://doi.org/10.4049/jimmunol.1700431
The Journal of Immunology Author Choice

TCR stimulation by peptide–MHC complexes on APCs requires precise reorganization of molecules into the area of cellular contact to form an immunological synapse from where T cell signaling is initiated. Caveolin (Cav)1, a widely expressed transmemb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d65275893949f2cb6045fe1a1b0a4f2c
https://doi.org/10.4049/jimmunol.1700431

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Extracellular vesicles from a helminth parasite suppress macrophage activation and constitute an effective vaccine for protective immunity

Autor: Jessica G. Borger, Elaine Robertson, Jana McCaskill, Henry J. McSorley, Rick M. Maizels, Yvonne Harcus, Amy H. Buck, Fabio Simbari, Gillian Coakley, Marissa Millar

Publikováno v: Cell Reports, Vol 19, Iss 8, Pp 1545-1557 (2017)
Cell Reports
Coakley, G, McCaskill, J L, Borger, J G, Simbari, F, Robertson, E, Millar, M, Harcus, Y, McSorley, H J, Maizels, R M & Buck, A H 2017, ' Extracellular vesicles from a helminth parasite suppress macrophage activation and constitute an effective vaccine for protective immunity ', Cell Reports, vol. 19, no. 8, pp. 1545-1557 . https://doi.org/10.1016/j.celrep.2017.05.001

Summary Recent studies have demonstrated that many parasites release extracellular vesicles (EVs), yet little is known about the specific interactions of EVs with immune cells or their functions during infection. We show that EVs secreted by the gast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::332e0ff9cd4b673d8c9b1217e624d7c0
https://eprints.gla.ac.uk/142915/1/142915.pdf

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3-Deoxy-3,4-dehydro analogs of XM462. Preparation and activity on sphingolipid metabolism and cell fate

Autor: Fabio Simbari, Gemma Fabriàs, Luz Camacho, Josefina Casas, Maria Del Mar Capeans Garrido, Antonio Delgado, José Luis Abad

Publikováno v: Bioorganic & Medicinal Chemistry. 20:3173-3179

Three analogs of the dihydroceramide desaturase inhibitor XM462 are reported. The compounds inhibit both dihydroceramide desaturase and acid ceramidase, but with different potencies depending on the N-acyl moiety. Other enzymes of sphingolipid metabo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4577d0d86acee3f30e301248da70516
https://doi.org/10.1016/j.bmc.2012.03.073

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Regulation of CC Ligand 5/RANTES by Acid Sphingomyelinase and Acid Ceramidase

Autor: Ashley J. Snider, Christopher R. Gault, Fabio Simbari, Yusuf A. Hannun, Linda A. Heffernan-Stroud, Russell W. Jenkins, Daniel Canals, Patrick Roddy, Bill X. Wu, Lina M. Obeid, Kazuyuki Kitatani, Christopher J. Clarke

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Acid sphingomyelinase (aSMase) generates the bioactive lipid ceramide (Cer) from hydrolysis of sphingomyelin (SM). However, its precise roles in regulating specific sphingolipid-mediated biological processes remain ill defined. Interestingly, the aSM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d94868ddbe5ecd9b1dc414addcc58cd
https://doi.org/10.1074/jbc.m110.163378

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A Novel Mechanism of Lysosomal Acid Sphingomyelinase Maturation

Autor: Daniel Canals, Fabio Simbari, Yusuf A. Hannun, Christopher J. Clarke, Patrick Roddy, Clarke D. Riner, Jolanta Idkowiak-Baldys, Russell W. Jenkins

Publikováno v: Journal of Biological Chemistry. 286:3777-3788

Acid sphingomyelinase (aSMase) catalyzes the hydrolysis of sphingomyelin (SM) to form the bioactive lipid ceramide (Cer). Notably, aSMase exists in two forms: a zinc (Zn2+)-independent lysosomal aSMase (L-SMase) and a Zn2+-dependent secreted aSMase (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3983d756e8097b693d448b9de13b72c
https://doi.org/10.1074/jbc.m110.155234

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Regulated Secretion of Acid Sphingomyelinase

Autor: Patrick Roddy, Fabio Simbari, Daniel Canals, Chiara Luberto, Yusuf A. Hannun, Kazuyuki Kitatani, Jolanta Idkowiak-Baldys, David M. Perry, Russell W. Jenkins

Publikováno v: Journal of Biological Chemistry. 285:35706-35718

The acid sphingomyelinase (aSMase) gene gives rise to two distinct enzymes, lysosomal sphingomyelinase (L-SMase) and secretory sphingomyelinase (S-SMase), via differential trafficking of a common protein precursor. However, the regulation of S-SMase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ac47d3c802c01eb133885cd60fe1ded
https://doi.org/10.1074/jbc.m110.125609

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