Blood cell count indexes as predictors of anastomotic leakage in elective colorectal surgery: a multicenter study on 1432 patients

Autor: Panagiotis Paliogiannis, Simona Deidda, Svilen Maslyankov, Tsvetelina Paycheva, Ahmed Farag, Abdrabou Mashhour, Evangelos Misiakos, Dimitrios Papakonstantinou, Michal Mik, Joanna Losinska, Fabrizio Scognamillo, Fabio Sanna, Claudio Francesco Feo, Giuseppe Cherchi, Andreas Xidas, Angelo Zinellu, Angelo Restivo, Luigi Zorcolo

Publikováno v: World Journal of Surgical Oncology, Vol 18, Iss 1, Pp 1-8 (2020)

Abstract Background The aim of this study was to evaluate a series of blood count inflammation indexes in predicting anastomotic leakage (AL) in elective colorectal surgery. Methods Demographic, pathologic, and clinical data of 1432 consecutive patie

Externí odkaz: https://doaj.org/article/472e396977764b589bd9626e2b319ae0

7[alpha]-hydroxy-3-oxo-4-cholestenoic acid (7-HOCA) is a novel AKR1D1 substrate driving metabolic dysfunction and hepatocellular cancer risk in patients with non-alcoholic fatty liver disease (NAFLD)

Autor: Nikolaos Nikolaou, Anastasia Arvaniti, Fabio Sanna, Conceicao Ismael da, Niall Dempster, Laura Gathercole, Jeremy Tomlinson

Publikováno v: Endocrine Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7158925c1d29d40d2382f4f747f1a055
https://doi.org/10.1530/endoabs.86.oc5.2

Chronic inflammatory arthritis drives systemic changes in circadian energy metabolism

Autor: Polly Downton, Fabio Sanna, Robert Maidstone, Toryn M. Poolman, Edward A. Hayter, Suzanna H. Dickson, Nick A. Ciccone, James O. Early, Antony Adamson, David G. Spiller, Devin A. Simpkins, Matthew Baxter, Roman Fischer, Magnus Rattray, Andrew S. I. Loudon, Julie E. Gibbs, David A. Bechtold, David W. Ray

Publikováno v: Downton, P, Sanna, F, Maidstone, R, Poolman, T, Hayter, E, Dickson, S, Early, J, Adamson, A, Spiller, D, Simpkins, D, Baxter, M, Fischer, R, Rattray, M, Loudon, A, Gibbs, J, Bechtold, D & Ray, D 2022, ' Chronic inflammatory arthritis drives systemic changes in circadian energy metabolism ', PNAS . https://doi.org/10.1073/pnas.2112781119

Chronic inflammation underpins many human diseases. Morbidity and mortality associated with chronic inflammation are often mediated through metabolic dysfunction. Inflammatory and metabolic processes vary through circadian time, suggesting an importa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017529c2364b29af243534f1e7291915
https://research.manchester.ac.uk/en/publications/800a87b1-8e94-4db1-bc84-0c5accdfbaf1

Blood cell count indexes as predictors of anastomotic leakage in elective colorectal surgery: a multicenter study on 1432 patients

Autor: Fabio Sanna, Luigi Zorcolo, Fabrizio Scognamillo, Tsvetelina Paycheva, Dimitrios Papakonstantinou, Ahmed Farag, Claudio F. Feo, Abdrabou N. Mashhour, Angelo Restivo, Evangelos P. Misiakos, Giuseppe Cherchi, Panagiotis Paliogiannis, Michał Mik, S. Deidda, Angelo Zinellu, Svilen Maslyankov, Joanna Losinska, Andreas Xidas

Publikováno v: World Journal of Surgical Oncology, Vol 18, Iss 1, Pp 1-8 (2020)
World Journal of Surgical Oncology

Background The aim of this study was to evaluate a series of blood count inflammation indexes in predicting anastomotic leakage (AL) in elective colorectal surgery. Methods Demographic, pathologic, and clinical data of 1432 consecutive patients submi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe60300c221d0d4c2601d8c22553ad0
https://doi.org/10.1186/s12957-020-01856-1

Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17//RAC1-mediated activation of NADPH oxidases

Autor: Eileen McNeill, Constantinos Christodoulides, Alexios S. Antonopoulos, Patricia Coutinho, Harry Fagan, Ashley B. Hale, Dimitris Tousoulis, Marios Margaritis, Evangelos Oikonomou, Christos P Kotanidis, George Krasopoulos, Lei Lv, Nadia Akawi, Keith M. Channon, Fabio Sanna, Rana Sayeed, Sheena Thomas, L Herdman, Gillian Douglas, Amy P. Chiu, Meisam Naeimi Kararoudi, Sarah J George, Ioannis Akoumianakis, Surawee Chuaiphichai, Ileana Badi, Charalambos Antoniades, Mario Petrou

Publikováno v: Sci Transl Med
Akoumianakis, I, Sanna, F, Margaritis, M, Badi, I, Akawi, N, Herdman, L, Coutinho, P, Fagan, H, Antonopoulos, A S, Oikonomou, E K, Thomas, S, Chiu, A P, Chuaiphichai, S, Kotanidis, C P, Christodoulides, C, Petrou, M, Krasopoulos, G, Sayeed, R, Lv, L, Hale, A, Naeimi Kararoudi, M, McNeill, E, Douglas, G, George, S, Tousoulis, D, Channon, K M & Antoniades, C 2019, ' Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17//RAC1-mediated activation of NADPH oxidases ', Science Translational Medicine, vol. 11, no. 510, eaav5055 . https://doi.org/10.1126/scitranslmed.aav5055

Obesity is associated with changes in the secretome of adipose tissue (AT), which affects the vasculature through endocrine and paracrine mechanisms. Wingless-related integration site 5A (WNT5A) and secreted frizzled-related protein 5 (SFRP5), adipok

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dff64269e824aeb84b61c833c523fac
https://doi.org/10.1126/scitranslmed.aav5055