Nuclear Receptors and the Hidden Language of the Metabolome

Autor: Yujie Chen, Matthew Tom Anderson, Nathaniel Payne, Fabio R. Santori, Natalia B. Ivanova

Publikováno v: Cells, Vol 13, Iss 15, p 1284 (2024)

Nuclear hormone receptors (NHRs) are a family of ligand-regulated transcription factors that control key aspects of development and physiology. The regulation of NHRs by ligands derived from metabolism or diet makes them excellent pharmacological tar

Externí odkaz: https://doaj.org/article/461617f9649c4cf5902d3038ae319aa3

Identification of Natural ROR gamma Ligands that Regulate the Development of Lymphoid Cells

Autor: Fabio R. Santori, Gregor Lorbek, Pengxiang Huang, Rok Keber, Alain Rahier, Brittany N. Rosales, W. David Nes, Simon Horvat, Damjana Rozman, Serge A. van de Pavert, David J. Leaver, Brad A. Haubrich, Dan R. Littman, Eugene F. Douglass, Fraydoon Rastinejad, Reina E. Mebius, Tanja Konijn

Publikováno v: Santori, F R, Huang, P X, van de Pavert, S A, Douglass, E F, Leaver, D J, Haubrich, B A, Keber, R, Lorbek, G, Konijn, T, Rosales, B N, Rozman, D, Horvat, S, Rahier, A, Mebius, R E, Rastinejad, F, Nes, W D & Littman, D R 2015, ' Identification of Natural ROR gamma Ligands that Regulate the Development of Lymphoid Cells ', Cell Metabolism, vol. 21, no. 2, pp. 286-297 . https://doi.org/10.1016/j.cmet.2015.01.004
Cell Metabolism, 21(2), 286-297. Cell Press

Mice deficient in the nuclear hormone receptor RORγt have defective development of thymocytes, lymphoid organs, Th17 cells, and type 3 innate lymphoid cells. RORγt binds to oxysterols derived from cholesterol catabolism, but it is not clear whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9954ffd3b62b7c6a9ee55d203f9cea
https://doi.org/10.1016/j.cmet.2015.01.004

The immune system as a self-centered network of lymphocytes

Autor: Fabio R. Santori

This essay makes a brief historical and comparative review of selective and network theories of the immune system which is presented as a chemical sensory system with immune and non-immune functions. The ontogeny of immune networks is the result of b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::109dfe9c37ed67af7840e25c7a9a8c90
https://europepmc.org/articles/PMC4501489/

Self-peptide/MHC and TCR antagonism: Physiological role and therapeutic potential

Autor: Fabio R. Santori, Stanislav Vukmanovic

Publikováno v: Cellular Immunology. 233:75-84

TCR antagonists are peptides that bind MHC molecules and can specifically inhibit T cell activation induced by antigens. Studying TCR antagonism has taken an important place in immunology for both theoretical and practical reasons. Deciphering the me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed670ee45f7256b77d0287e1b038f5e8
https://doi.org/10.1016/j.cellimm.2005.04.011

Genomics-based identification of self-ligands with T cell receptor-specific biological activity

Autor: Stuart M. Brown, Fabio R. Santori, Stanislav Vukmanovic

Publikováno v: Immunological Reviews. 190:146-160

Self-peptide/major histocompatibility complex (MHC) complexes profoundly influence the biology of T lymphocytes. They promote the selection of the T cell receptor (TCR) repertoire in the thymus, maintain the homeostasis of peripheral T cells prior to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3cbce3842bc47c556bd437a4f8eb75c5
https://doi.org/10.1034/j.1600-065x.2002.19011.x