Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Fabio Mario Spiga"'
Autor:
Daniel Snell, Tea Gunde, Stefan Warmuth, Bithi Chatterjee, Matthias Brock, Christian Hess, Maria Johansson, Alexandre Simonin, Fabio Mario Spiga, Christopher Weinert, Niels Kirk, Nicole Bassler, Lucia Campos Carrascosa, Naomi Flückiger, Robin Heiz, Sandro Wagen, Noreen Giezendanner, Alessandra Alberti, Yasemin Yaman, Dana Mahler, Dania Diem, Peter Lichtlen, David Urech
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTMesothelin (MSLN) is an attractive immuno-oncology target, but the development of MSLN-targeting therapies has been impeded by tumor shedding of soluble MSLN (sMSLN), on-target off-tumor activity, and an immunosuppressive tumor microenvironme
Externí odkaz:
https://doaj.org/article/37427098ffe74543b7338afdbca88496
Autor:
Maria U. Johansson, Christopher Weinert, Dietrich Alexander Reichardt, Dana Mahler, Dania Diem, Christian Hess, Diana Feusi, Simon Carnal, Julia Tietz, Noreen Giezendanner, Fabio Mario Spiga, David Urech, Stefan Warmuth
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTUpon reformatting of an antibody to single-chain variable fragment format, a region in the former variable/constant domain interface of the heavy chain becomes accessible for preexisting (PE) anti-drug antibody (ADA) binding. The region expos
Externí odkaz:
https://doaj.org/article/b59c6c9046354f519ced556acc07494f
Autor:
Stefan Warmuth, Tea Gunde, Daniel Snell, Matthias Brock, Christopher Weinert, Alexandre Simonin, Christian Hess, Julia Tietz, Maria Johansson, Fabio Mario Spiga, Robin Heiz, Naomi Flückiger, Sandro Wagen, Julia Zeberer, Dania Diem, Dana Mahler, Belinda Wickihalder, Simone Muntwiler, Bithi Chatterjee, Benjamin Küttner, Bettina Bommer, Yasemin Yaman, Peter Lichtlen, David Urech
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Co-stimulatory 4–1BB receptors on tumor-infiltrating T cells are a compelling target for overcoming resistance to immune checkpoint inhibitors, but initial clinical studies of 4–1BB agonist mAbs were accompanied by liver toxicity. We sought to en
Externí odkaz:
https://doaj.org/article/2cef15a66dc442d1a31020e1730a9800
Autor:
Stefan Warmuth, Tea Gunde, Daniel Snell, Matthias Brock, Christopher Weinert, Alexandre Simonin, Christian Hess, Julia Tietz, Maria Johansson, Fabio Mario Spiga, Robin Heiz, Naomi Flückiger, Sandro Wagen, Julia Zeberer, Dania Diem, Dana Mahler, Belinda Wickihalder, Simone Muntwiler, Bithi Chatterjee, Benjamin Küttner, Bettina Bommer, Yasemin Yaman, Peter Lichtlen, David Urech
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Co-stimulatory 4–1BB receptors on tumor-infiltrating T cells are a compelling target for overcoming resistance to immune checkpoint inhibitors, but initial clinical studies of 4–1BB agonist mAbs were accompanied by liver toxicity. We sought to en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c65a392b42386048d75da1b31b47ae5
https://pubmed.ncbi.nlm.nih.gov/35844969
https://pubmed.ncbi.nlm.nih.gov/35844969
Autor:
Joël Nicolet, Vilde Olsson, Fabio Mario Spiga, Ludwig A. Hothorn, Julia Santiago, Ulrich Hohmann, Melinka A. Butenko, Michael Hothorn
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America 115 (2018), Nr. 13
Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 13, pp. 3488-3493
Proceedings of the National Academy of Sciences (2018)
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 13, pp. 3488-3493
Proceedings of the National Academy of Sciences (2018)
Proceedings of the National Academy of Sciences of the United States of America
Significance Plants contain a unique family of membrane receptors, which are different from the ones found in bacteria and animals. These proteins are able to sense very different signals, such as steroid molecules, peptides, and proteins at the cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6a47fc35a18fecd13016b14b95624c
http://www.repo.uni-hannover.de/handle/123456789/3390
http://www.repo.uni-hannover.de/handle/123456789/3390
Publikováno v:
DNA Nanotechnology ISBN: 9781493985814
Capture-SELEX is an effective molecular strategy enabling the discovery of structure-switching aptamers, which might find useful application in molecular detection or separation. We here provide a protocol to perform capture-SELEX for DNA aptamers bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f3597da575b44de938a83e23a3ed95
https://doi.org/10.1007/978-1-4939-8582-1_13
https://doi.org/10.1007/978-1-4939-8582-1_13
Autor:
Fabio Mario Spiga, Michael Beyeler, Yessica Moncada, Carlotta Guiducci, Thierry Buclin, Anna M. Ferretti, Marco Bianchessi, Laurent A. Decosterd, Giulia Cappi
Publikováno v:
Analytical Chemistry. 87:5278-5285
In order to improve the efficacy and safety of treatments, drug dosage needs to be adjusted to the actual needs of each patient in a truly personalized medicine approach. Key for widespread dosage adjustment is the availability of point-of-care devic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e5c993c5d30a645823fc1bce232c76
https://doi.org/10.1021/acs.analchem.5b00389
https://doi.org/10.1021/acs.analchem.5b00389
The TAO kinase KIN-18 regulates contractility and establishment of polarity in the C. elegans embryo
Publikováno v:
Developmental Biology, Vol. 373, No 1 (2013) pp. 26-38
Cell polarity is crucial for many aspects of cell and developmental biology. Cytoskeleton remodeling plays an essential role in the establishment of cell polarity. In the Caenorhabditis elegans one-cell embryo, while the actomyosin cytoskeleton is re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f36e57a80c65802fd089a28d8ccb5df
Autor:
Enrico Accastelli, Luca Benini, Giulia Cappi, Maria Anita Rampi, Carlotta Guiducci, Fabio Mario Spiga, Vera Cantale
Publikováno v:
MRS Proceedings. 1479:27-32
In the framework of bioanalytics and multiple array detection, we developed a fully portable and low-cost detection system based on Localized Surface Plasmon Resonance (LSPR) in a transmission configuration (T-LSPR). The transmission approach is suit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ace514e37570501ac311db5f90524fb
https://doi.org/10.1557/opl.2012.1593
https://doi.org/10.1557/opl.2012.1593
Autor:
Fabio Mario Spiga, Paola Spadone, Piero Attilio Bianco, Paola Casati, Alberto Alma, Fabio Quaglino, Rosemarie Tedeschi
Publikováno v:
Journal of Phytopathology. 158:81-87
Apple proliferation (AP) is an important disease and is prevalent in several European countries. The causal agent of AP is ‘Candidatus Phytoplasma mali’ (‘Ca. Phytoplasma mali’). In this work, isolates of ‘Ca. Phytoplasma mali’ were detec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d590472f758bb3a2f4b6dcd6f982271
https://doi.org/10.1111/j.1439-0434.2009.01581.x
https://doi.org/10.1111/j.1439-0434.2009.01581.x