Zobrazeno 1 - 10
of 400
pro vyhledávání: '"Fabio MALAVASI"'
Autor:
Kamlesh Bisht, Taro Fukao, Marielle Chiron, Paul Richardson, Djordje Atanackovic, Eduardo Chini, Wee Joo Chng, Helgi Van De Velde, Fabio Malavasi
Publikováno v:
Cancer Medicine, Vol 12, Iss 20, Pp 20332-20352 (2023)
Abstract Background CD38 has been established as an important therapeutic target for multiple myeloma (MM), for which two CD38 antibodies are currently approved—daratumumab and isatuximab. CD38 is an ectoenzyme that degrades NAD and its precursors
Externí odkaz:
https://doaj.org/article/11c9e5f0da7846b4a4ba574aa7ba86ce
Autor:
Anne Chong, Serenella Tolomeo, Yue Xiong, Dario Angeles, Mike Cheung, Benjamin Becker, Poh San Lai, Zhen Lei, Fabio Malavasi, Qianzi Tang, Soo Hong Chew, Richard P. Ebstein
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Converging evidence suggests that oxytocin (OT) is associated with creative thinking (CT) and that release of OT depends on ADP ribosyl-cyclases (CD38 and CD157). Neural mechanisms of CT and OT show a strong association with dopaminergic (DA
Externí odkaz:
https://doaj.org/article/918e8fe0a3354e3f8787043805e3d29f
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Nicotinamide adenine dinucleotide (NAD+) is an important molecule that functions as a co-enzyme in numerous metabolic processes. Generated both through de novo synthesis and via salvage pathways, NAD+ is the substrate for a variety of NAD+-consuming
Externí odkaz:
https://doaj.org/article/d1aa3c8015ea47e3ab9b215b806ebedd
Autor:
Michelle Kinder, Nizar J. Bahlis, Fabio Malavasi, Bart de Goeij, Alexander Babich, Jocelyn Sendecki, Joshua Rusbuldt, Kevin Bellew, Colleen Kane, Niels W.C.J. van de Donk
Publikováno v:
Haematologica, Vol 106, Iss 7 (2021)
Externí odkaz:
https://doaj.org/article/04bb5056edc14521a6d3677dd42ad9b6
Autor:
Valerie Chew, Tony Kiat Hon Lim, David Tai, Su Pin Choo, Joe Yeong, Jeffrey Chun Tatt Lim, Bernett Lee, Huihua Li, Sahil Saraf, Han Chong Toh, Benedict Tan, Harry Ho Man Ng, Ren Yuan Lee, Siting Goh, Isabel Shu Ying Tay, Xinru Lim, Sherlly Lim, Bijin Au, Josh Jie Hua Loh, John Edward Connolly, Tracy Loh, Wei Qiang Leow, Joycelyn Jie Xin Lee, Fabio Malavasi, Ser Yee Lee, Pierce Chow, Evan W Newell
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Introduction Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-associated mortality globally. Immune-checkpoint blockade (ICB) is one of the systemic therapy options for HCC. However, response rates remain low, necessitating robust
Externí odkaz:
https://doaj.org/article/63bba1dbcae64136851847771b46dfaf
Autor:
Orazio Fortunato, Dimas Carolina Belisario, Mara Compagno, Francesca Giovinazzo, Cristiano Bracci, Ugo Pastorino, Alberto Horenstein, Fabio Malavasi, Riccardo Ferracini, Stefania Scala, Gabriella Sozzi, Luca Roz, Ilaria Roato, Giulia Bertolini
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Cancer stem cells (CSCs) are functionally defined as the cell subset with greater potential to initiate and propagate tumors. Within the heterogeneous population of lung CSCs, we previously identified highly disseminating CD133+CXCR4+ cells able to i
Externí odkaz:
https://doaj.org/article/7f22199dd81f4a9aacee719fd3869c9f
Autor:
Giulia Mesiano, Roberta Zini, Giulia Montagner, Nicoletta Bianchi, Rossella Manfredini, Antonella Chillemi, Massimo Aglietta, Giovanni Grignani, Ilaria Lampronti, Erika Fiorino, Fabio Malavasi, Dario Sangiolo, Roberto Gambari, Davide Ferrari
Publikováno v:
Molecular Medicine, Vol 23, Iss 1, Pp 235-246 (2017)
Abstract Adoptive immunotherapy with cytokine induced killer (CIK) cells has shown antitumor activity against several kinds of cancer in preclinical models and clinical trials. CIK cells are a subset of ex vivo expanded T lymphocytes with T-NK phenot
Externí odkaz:
https://doaj.org/article/3509274270af4e2b976fc7342fa521a1
Autor:
Eri Katsuyama, Abel Suarez-Fueyo, Sean J. Bradley, Masayuki Mizui, Ana V. Marin, Lama Mulki, Suzanne Krishfield, Fabio Malavasi, Joon Yoon, Shannan J. Ho Sui, Vasileios C. Kyttaris, George C. Tsokos
Publikováno v:
Cell Reports, Vol 30, Iss 1, Pp 112-123.e4 (2020)
Summary: Patients with systemic lupus erythematosus (SLE) suffer frequent infections that account for significant morbidity and mortality. T cell cytotoxic responses are decreased in patients with SLE, yet the responsible molecular events are largely
Externí odkaz:
https://doaj.org/article/a9af69c5ef994507a2ab02f4b9f4a91f
Autor:
Jian Hang Lam, Harry Ho Man Ng, Chun Jye Lim, Xin Ni Sim, Fabio Malavasi, Huihua Li, Josh Jie Hua Loh, Khin Sabai, Joo-Kyung Kim, Clara Chong Hui Ong, Tracy Loh, Wei Qiang Leow, Su Pin Choo, Han Chong Toh, Ser Yee Lee, Chung Yip Chan, Valerie Chew, Tong Seng Lim, Joe Yeong, Tony Kiat Hon Lim
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Background: CD38 is involved in the adenosine pathway, which represents one of the immunosuppressive mechanisms in cancer. CD38 is broadly expressed across immune cell subsets, including human macrophages differentiated in vitro from monocytes, but e
Externí odkaz:
https://doaj.org/article/2d5e6ac5b33e4907b8e37e585527404f
Autor:
Nicola Giuliani, Fabio Malavasi
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/2bf564bb227246b2b7ccc3a78cb9c797