Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Fabio M R. Amaral"'
Autor:
Zichen Wang, Caroline D. Monteiro, Kathleen M. Jagodnik, Nicolas F. Fernandez, Gregory W. Gundersen, Andrew D. Rouillard, Sherry L. Jenkins, Axel S. Feldmann, Kevin S. Hu, Michael G. McDermott, Qiaonan Duan, Neil R. Clark, Matthew R. Jones, Yan Kou, Troy Goff, Holly Woodland, Fabio M R. Amaral, Gregory L. Szeto, Oliver Fuchs, Sophia M. Schüssler-Fiorenza Rose, Shvetank Sharma, Uwe Schwartz, Xabier Bengoetxea Bausela, Maciej Szymkiewicz, Vasileios Maroulis, Anton Salykin, Carolina M. Barra, Candice D. Kruth, Nicholas J. Bongio, Vaibhav Mathur, Radmila D Todoric, Udi E. Rubin, Apostolos Malatras, Carl T. Fulp, John A. Galindo, Ruta Motiejunaite, Christoph Jüschke, Philip C. Dishuck, Katharina Lahl, Mohieddin Jafari, Sara Aibar, Apostolos Zaravinos, Linda H. Steenhuizen, Lindsey R. Allison, Pablo Gamallo, Fernando de Andres Segura, Tyler Dae Devlin, Vicente Pérez-García, Avi Ma’ayan
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
A wealth of gene expression data is publicly available, yet is little use without additional human curation. Ma’ayan and colleagues report a crowdsourcing project involving over 70 participants to annotate and analyse thousands of human disease-rel
Externí odkaz:
https://doaj.org/article/a8f2b28d890e4a0e99fc75b9634da8c0
Autor:
Yu-Hung Wang, Chien-Chin Lin, Chi-Yuan Yao, Kristian Gurashi, Fabio M. R. Amaral, Luciano Nicosia, Bettina Wingelhofer, Kiran Batta, Daniel Wiseman, Hsin-An Hou, Wen Chien Chou, Hwei-Fang Tien
Publikováno v:
HemaSphere, Vol 7, p e079759f (2023)
Externí odkaz:
https://doaj.org/article/cbde4245b8eb4f99a4df1f982fcf4508
Autor:
Yu-Hung Wang, Kristian Gurashi, Chien-Chin Lin, Chi-Yuan Yao, Fabio M. R. Amaral, Andres Jerez, Tim C. P. Somervaille, Hsin-An Hou, Wen Chien Chou, Kiran Batta, Daniel Wiseman, Hwei-Fang Tien
Publikováno v:
HemaSphere, Vol 7, p e29768b6 (2023)
Externí odkaz:
https://doaj.org/article/4985529cc41d4a768f03df4ac7902db8
Autor:
Stella Pearson, Rognvald Blance, Fei Yan, Ya-Ching Hsieh, Bethany Geary, Fabio M R Amaral, Tim C P Somervaille, Kristina Kirschner, Anthony D Whetton, Andrew Pierce
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0286412 (2023)
Myelofibrosis is a myeloproliferative neoplasm (MPN) which typically results in reduced length and quality of life due to systemic symptoms and blood count changes arising from fibrotic changes in the bone marrow. While the JAK2 inhibitor ruxolitinib
Externí odkaz:
https://doaj.org/article/68dcd073260444a9951df4bb64585f57
Autor:
Mark S. Williams, Naseer J. Basma, Fabio M. R. Amaral, Gillian Williams, John P. Weightman, Wolfgang Breitwieser, Louisa Nelson, Stephen S. Taylor, Daniel H. Wiseman, Tim C. P. Somervaille
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background Resistance to chemotherapy is the most common cause of treatment failure in acute myeloid leukemia (AML) and the drug efflux pump ABCB1 is a critical mediator. Recent studies have identified promoter translocations as common drive
Externí odkaz:
https://doaj.org/article/4b1fecc0eb29435794db48447177a4ea
Autor:
Yu‐Hung Wang, Chi‐Yuan Yao, Chien‐Chin Lin, Kristian Gurashi, Fabio M. R. Amaral, Hasse Bossenbroek, Andres Jerez, Tim C. P. Somervaille, Moritz Binder, Mrinal M. Patnaik, Hsin‐An Hou, Wen‐Chien Chou, Kiran Batta, Daniel H. Wiseman, Hwei‐Fang Tien
Publikováno v:
British Journal of Haematology. 201:302-307
Autor:
Alba Maiques-Diaz, Luciano Nicosia, Naseer J. Basma, Isabel Romero-Camarero, Francesco Camera, Gary J. Spencer, Fabio M. R. Amaral, Fabrizio Simeoni, Bettina Wingelhofer, Andrew J. K. Williamson, Andrew Pierce, Anthony D. Whetton, Tim C. P. Somervaille
Publikováno v:
Oncogene. 41:4841-4854
Pharmacologic inhibition of LSD1 induces molecular and morphologic differentiation of blast cells in acute myeloid leukemia (AML) patients harboring MLL gene translocations. In addition to its demethylase activity, LSD1 has a critical scaffolding fun
Autor:
Rachel E. Miles, Catherine Cargo, Mohammad Alinoor Rahman, Omar Abdel-Wahab, Adrian R. Krainer, Heidi Dvinge, Hana Cho, Robert K. Bradley, Todd R. Albrecht, Fabio M. R. Amaral, Ross L. Levine, Kiran Batta, Daichi Inoue, Fabrizio Simeoni, Deepti P. Wilks, Alessandro Pastore, Bo Wang, Xiao Jing Zhang, Daniel H. Wiseman, Eric J. Wagner, Stéphane de Botton, Eytan M. Stein, Tim C. P. Somervaille, Jean Baptiste Micol, Virginie Penard-Lacronique, Andrew M. Intlekofer, Stanley Chun-Wei Lee, Akihide Yoshimi, Kuan-Ting Lin
Publikováno v:
Nature
Transcription and pre-mRNA splicing are key steps in the control of gene expression and mutations in genes regulating each of these processes are common in leukaemia1,2. Despite the frequent overlap of mutations affecting epigenetic regulation and sp
Autor:
Mark S. Williams, Fabio M. R. Amaral, Tim C. P. Somervaille, Daniel H. Wiseman, Naseer J. Basma
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-15 (2021)
BMC Cancer
BMC Cancer
Background Disease relapse remains common following treatment of acute myeloid leukemia (AML) and is due to chemoresistance of leukemia cells with disease repopulating potential. To date, attempts to define the characteristics of in vivo resistant bl
Autor:
Georges Lacaud, Jason S. Carroll, Oliver J. Sinclair, Evangelia K. Papachristou, Gary J. Spencer, Daniel H. Wiseman, Isabel Romero-Camarero, Tim C. P. Somervaille, Francesco Camera, Fabio M. R. Amaral, Fabrizio Simeoni, Michael Lie-A-Ling
Publikováno v:
Cell Reports
Cell Reports, Vol 36, Iss 12, Pp 109725-(2021)
Cell Reports, Vol 36, Iss 12, Pp 109725-(2021)
Summary Despite absent expression in normal hematopoiesis, the Forkhead factor FOXC1, a critical mesenchymal differentiation regulator, is highly expressed in ∼30% of HOXAhigh acute myeloid leukemia (AML) cases to confer blocked monocyte/macrophage