Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Fabio Demontis"'
Autor:
Liam C. Hunt, Vishwajeeth Pagala, Anna Stephan, Boer Xie, Kiran Kodali, Kanisha Kavdia, Yong-Dong Wang, Abbas Shirinifard, Michelle Curley, Flavia A. Graca, Yingxue Fu, Suresh Poudel, Yuxin Li, Xusheng Wang, Haiyan Tan, Junmin Peng, Fabio Demontis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Ubiquitination is a post-translational modification initiated by the E1 enzyme UBA1, which transfers ubiquitin to ~35 E2 ubiquitin-conjugating enzymes. While UBA1 loss is cell lethal, it remains unknown how partial reduction in UBA1 activity
Externí odkaz:
https://doaj.org/article/ecc3809ff4864ac888167d9faaecd3c0
Autor:
Flavia A. Graca, Anna Stephan, Benjamin A. Minden-Birkenmaier, Abbas Shirinifard, Yong-Dong Wang, Fabio Demontis, Myriam Labelle
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Skeletal muscle regeneration involves coordinated interactions between different cell types. Injection of platelet-rich plasma is circumstantially considered an aid to muscle repair but whether platelets promote regeneration beyond their rol
Externí odkaz:
https://doaj.org/article/1e5137075a244f59ae84e93d0ac6ec9e
Autor:
Flavia A. Graca, Mamta Rai, Liam C. Hunt, Anna Stephan, Yong-Dong Wang, Brittney Gordon, Ruishan Wang, Giovanni Quarato, Beisi Xu, Yiping Fan, Myriam Labelle, Fabio Demontis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Myofiber atrophy occurs in many diseases but the mechanisms responsible for myofiber size determination are incompletely understood. Here, the authors show that the muscle-secreted factor Fibcd1 is necessary to maintain myofiber size and mitigates my
Externí odkaz:
https://doaj.org/article/5cbdb4d779ef41379fe96cd79ef579e7
Autor:
Jianqin Jiao, Michelle Curley, Flavia A. Graca, Maricela Robles-Murguia, Abbas Shirinifard, David Finkelstein, Beisi Xu, Yiping Fan, Fabio Demontis
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111970- (2023)
Summary: Protein quality control is important for healthy aging and is dysregulated in age-related diseases. The autophagy-lysosome and ubiquitin-proteasome are key for proteostasis, but it remains largely unknown whether other proteolytic systems al
Externí odkaz:
https://doaj.org/article/bde9aaea4839427f897ff30d5ece83b5
Autor:
Flavia A. Graca, Anna Stephan, Yong-Dong Wang, Abbas Shirinifard, Jianqin Jiao, Peter Vogel, Myriam Labelle, Fabio Demontis
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111934- (2023)
Summary: Cachexia is a systemic wasting syndrome that increases cancer-associated mortality. How cachexia progressively and differentially impacts distinct tissues is largely unknown. Here, we find that the heart and skeletal muscle undergo wasting a
Externí odkaz:
https://doaj.org/article/8b4e26a5247340eaaa1128d017b8e539
Publikováno v:
Bio-Protocol, Vol 12, Iss 11 (2022)
Aging and wasting of skeletal muscle reduce organismal fitness. Regrettably, only limited interventions are currently available to address this unmet medical need. Many methods have been developed to study this condition, including the intramuscular
Externí odkaz:
https://doaj.org/article/67220db936714edb848db60d5d88804f
Autor:
Liam C. Hunt, Bronwen Schadeberg, Jared Stover, Benard Haugen, Vishwajeeth Pagala, Yong-Dong Wang, Jason Puglise, Elisabeth R. Barton, Junmin Peng, Fabio Demontis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Sarcopenia is the age-associated functional decline and atrophy of muscle fibers, and it has been proposed that it might be counteracted by inducing myofiber hypertrophy. Here, the authors show that expression levels of the ubiquitin ligase UBR4 are
Externí odkaz:
https://doaj.org/article/696daac57df34ee1ab4b69517f4a1f99
Autor:
Flavia A Graca, Natalie Sheffield, Melissa Puppa, David Finkelstein, Liam C Hunt, Fabio Demontis
Publikováno v:
PLoS Genetics, Vol 17, Iss 11, p e1009926 (2021)
Myofiber atrophy occurs with aging and in many diseases but the underlying mechanisms are incompletely understood. Here, we have used >1,100 muscle-targeted RNAi interventions to comprehensively assess the function of 447 transcription factors in the
Externí odkaz:
https://doaj.org/article/5d5191f57c5148c0abfe03ddee05aa91
Autor:
Mamta Rai, Michelle Curley, Zane Coleman, Anjana Nityanandam, Jianqin Jiao, Flavia A. Graca, Liam C. Hunt, Fabio Demontis
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100628- (2021)
Summary: Defects in protein quality control are the underlying cause of age-related diseases. The western blot analysis of detergent-soluble and insoluble protein fractions has proven useful in identifying interventions that regulate proteostasis. He
Externí odkaz:
https://doaj.org/article/ca4e981144da47cfa6ff526512179354
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 5, Iss 1, Pp 1-5 (2019)
Abstract The GeneSwitch (GS) is a modified Gal4/UAS system, whereby transgene expression is induced in Drosophila by adding the drug RU486 to food. The GS system is routinely used in Drosophila aging and behavioral studies to avoid confounding effect
Externí odkaz:
https://doaj.org/article/0bdd8edebade4c678cefaaed563f6f11