Výsledky vyhledávání - "Fabio De Sessa"

Sister-chromatid exchanges, chromosomal aberrations and cytotoxicity produced by topoisomerase II-targeted drugs in sensitive (A2780) and resistant (A2780-DX3) human ovarian cancer cells: Correlations with the formation of DNA double-strand breaks

Autor: Elisabetta Rovini, Fabio De Sessa, Guido Cimoli, Elvira Noviello, Silvio Parodi, MariaGrazia Aluigi, Patrizia Russo, Alessandra Mazzoni

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 311:21-29

Doxorubicin, ellipticine and etoposide are antineoplastic drugs with topoisomerase II inhibitory activity. The relationship between drug-induced sister-chromatid exchanges (SCEs) or chromosomal aberrations (CAs) and cytotoxicity, or drug-induced DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6eacaa44a97fa49ef2bdeb4a169f5b4
https://doi.org/10.1016/0027-5107(94)90069-8

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Induction of DNA double-strand breaks by 8-methoxycaffeine: cell cycle dependence and comparison with topoisomerase II inhibitors

Autor: Patrizia Russo, Fabio De Sessa, Guido Cimoli, Yves Pommier, Silvio Parodi, Monica Valenti

Publikováno v: Carcinogenesis. 15(11)

We have studied the ability of 8-methoxycaffeine (8-MOC)--one of the most effective caffeine derivatives in inducing chromosomal aberrations--to induce DNA double strand breaks (DSB) in purified human T lymphocytes during the cell cycle. Etoposide- o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4959e8fc88c7b8ba0ac3e1bfbe582b3c
https://pubmed.ncbi.nlm.nih.gov/7955097

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