Tuning singlet oxygen generation with caged organic photosensitizers

Autor: Eleni Nestoros, Fabio de Moliner, Ferran Nadal-Bufi, Deborah Seah, M. Carmen Ortega-Liebana, Zhiming Cheng, Sam Benson, Catherine Adam, Larissa Maierhofer, Kostiantyn Kozoriz, Jun-Seok Lee, Asier Unciti-Broceta, Marc Vendrell

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)

Abstract Controlling the succession of chemical processes with high specificity in complex systems is advantageous for widespread applications, from biomedical research to drug manufacturing. Despite synthetic advances in bioorthogonal and photochemi

Externí odkaz: https://doaj.org/article/13707addf1d6484da1e50846859d06ee

Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo

Autor: Sam Benson, Fabio de Moliner, Antonio Fernandez, Erkin Kuru, Nicholas L. Asiimwe, Jun-Seok Lee, Lloyd Hamilton, Dirk Sieger, Isabel R. Bravo, Abigail M. Elliot, Yi Feng, Marc Vendrell

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Metabolites can distinguish pathogenic from healthy cells, but they are hard to couple to current photosensitizers without altering their biological activity. Here the authors design a new family of photosensitizers that retain metabolite function to

Externí odkaz: https://doaj.org/article/7c76d727336a4219a0b74bca92987546

Exploitation of the Ugi 5-Center-4-Component Reaction (U-5C-4CR) for the Generation of Diverse Libraries of Polycyclic (Spiro)Compounds

Autor: Lisa Moni, Fabio De Moliner, Silvia Garbarino, Jörn Saupe, Christian Mang, Andrea Basso

Publikováno v: Frontiers in Chemistry, Vol 6 (2018)

An Ugi multicomponent reaction with chiral cyclic amino acids, benzyl isocyanide and cyclic ketones (or acetone) has been exploited as key step for the generation of peptidomimetics. After a straightforward set of elaborations, the peptidomimetics we

Externí odkaz: https://doaj.org/article/a7ee0e49accd4b4a9217a59cbf0da7e7

Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores

Autor: Sam Benson, Ina Biazruchka, Karolina Konsewicz, Fabio de Moliner, Jun-Seok Lee, Suraj Singh, Marc Vendrell

Publikováno v: Frontiers of Chemical Science and Engineering
De Moliner, F, Biazruchka, I, Konsewicz, K, Benson, S, Singh, S, Lee, J-S & Vendrell, M 2021, ' Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores ', Frontiers of Chemical Science and Engineering . https://doi.org//10.1007/s11705-021-2080-8

The development of fluorophores emitting in the near-infrared spectral window has gained increased attention given their suitable features for biological imaging. In this work, we have optimised a general and straightforward synthetic approach to pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce5ca8861a2216397e148e0c2cb91ed2
https://doi.org/10.1007/s11705-021-2080-8

Miniaturized Chemical Tags for Optical Imaging

Autor: Sam Benson, Fabio de Moliner, William Tipping, Marc Vendrell

Publikováno v: Benson, S, De Moliner, F, Tipping, W & Vendrell, M 2022, ' Miniaturized Chemical Tags for Optical Imaging ', Angewandte Chemie International Edition . https://doi.org/10.1002/anie.202204788
Angewandte Chemie International Edition

Recent advances in optical bioimaging have prompted the need for minimal chemical reporters that can retain the molecular recognition properties and activity profiles of biomolecules. As a result, several methodologies to reduce the size of fluoresce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f27b897b3c0516d63c59ef256073fbe
https://doi.org/10.1002/anie.202204788