Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Fabio D. Steffen"'
Autor:
Malwine J. Barz, Lena Behrmann, Danaëlle Capron, Gabriele Zuchtriegel, Fabio D. Steffen, Leo Kunz, Yang Zhang, Iria Jimenez Vermeerbergen, Blerim Marovca, Moritz Kirschmann, Antonia Zech, César Nombela-Arrieta, Urs Ziegler, Timm Schroeder, Beat Bornhauser, Jean-Pierre Bourquin
Publikováno v:
Haematologica, Vol 108, Iss 5 (2022)
Persistence of residual disease after induction chemotherapy is a strong predictor of relapse in acute lymphoblastic leukemia (ALL). The bone marrow microenvironment may support escape from treatment. Using three-dimensional fluorescence imaging of t
Externí odkaz:
https://doaj.org/article/92a284cf059b4741ba558a277a2f6d2a
Autor:
Fabio D. Steffen, Mokrane Khier, Danny Kowerko, Richard A. Cunha, Richard Börner, Roland K. O. Sigel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Mobile group II introns function as ribozymes to splice and reinsert themselves into DNA, thereby colonizing new genomic regions. Here the authors use single-molecule FRET and molecular dynamics simulations to reveal a structural link between metal i
Externí odkaz:
https://doaj.org/article/8d43dc002f1d4cfa8c1f9fe4d715405c
Publikováno v:
CHIMIA, Vol 73, Iss 4 (2019)
Exploring the spatiotemporal dynamics of biomolecules on a single-molecule level requires innovative ways to make them spectroscopically visible. Fluorescence resonance energy transfer (FRET) uses a pair of organic dyes as reporters to measure distan
Externí odkaz:
https://doaj.org/article/acc43f3d087e470a9558478478a9b154
Autor:
Malwine J. Barz, Lena Behrmann, Danaëlle Capron, Gabriele Zuchtriegel, Fabio D. Steffen, Leo Kunz, Yang Zhang, Iria Jimenez Vermeerbergen, Blerim Marovca, Moritz Kirschmann, Antonia Zech, César Nombela-Arrieta, Urs Ziegler, Timm Schroeder, Beat Bornhauser, Jean-Pierre Bourquin
Publikováno v:
Haematologica, 108 (5)
Persistence of residual disease after induction chemotherapy is a strong predictor of relapse in acute lymphoblastic leukemia (ALL). The bone marrow microenvironment may support escape from treatment. Using three-dimensional fluorescence imaging of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb4965a9ce5d1619bb216022bfcd419
Autor:
Richard Börner, Mokrane Khier, Richard A. Cunha, Roland K. O. Sigel, Fabio D. Steffen, Danny Kowerko
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
The fidelity of group II intron self-splicing and retrohoming relies on long-range tertiary interactions between the intron and its flanking exons. By single-molecule FRET, we explore the binding kinetics of the most important, structurally conserved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f1dd827556319a6ad8c5bbfbf1c0fb
https://doaj.org/article/8d43dc002f1d4cfa8c1f9fe4d715405c
https://doaj.org/article/8d43dc002f1d4cfa8c1f9fe4d715405c
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2439
Fast and efficient site-specific labeling of long RNAs is one of the main bottlenecks limiting distance measurements by means of Förster resonance energy transfer (FRET) or electron paramagnetic resonance (EPR) spectroscopy. Here, we present an opti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2bb41ffb1eed993083130009568087bc
https://pubmed.ncbi.nlm.nih.gov/35226323
https://pubmed.ncbi.nlm.nih.gov/35226323
Summary Quantitative interpretation of single-molecule FRET experiments requires a model of the dye dynamics to link experimental energy transfer efficiencies to distances between atom positions. We have developed FRETraj, a Python module to predict
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a1c07dd73546d78b75eb565eb6f77a1
https://doi.org/10.5167/uzh-215175
https://doi.org/10.5167/uzh-215175
Publikováno v:
Physical Chemistry Chemical Physics. 18:29045-29055
Carbocyanine dyes have a long-standing tradition in fluorescence imaging and spectroscopy, due to their photostability and large spectral separation between individual dye species. Herein, we explore the versatility of cyanine dyes to probe the dynam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59de67d4f000657a3d767be4e7e97b65
https://doi.org/10.1039/c6cp04277e
https://doi.org/10.1039/c6cp04277e
Publikováno v:
Single Molecule Spectroscopy and Superresolution Imaging IX.
The popularity of carbocyanine dyes in single molecule spectroscopy of nucleic acids is unbroken [1]. Studying the dynamics of large RNA constructs and the binding kinetics such as the exon/intron binding side interaction of the group II intron in S.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::741a6c60195fb225d886f9ecf04491b9
https://doi.org/10.1117/12.2212176
https://doi.org/10.1117/12.2212176
Autor:
Meng Zhao, Eva Freisinger, Richard Börner, Fabio D. Steffen, Michelle F. Schaffer, Roland K. O. Sigel
Publikováno v:
Nucleic Acids Research
Labeling of long RNA molecules in a site-specific yet generally applicable manner is integral to many spectroscopic applications. Here we present a novel covalent labeling approach that is site-specific and scalable to long intricately folded RNAs. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b898fe28489a42d888e5a411acb6bf9
http://europepmc.org/articles/PMC5814972
http://europepmc.org/articles/PMC5814972