Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Fabio Bignami"'
Autor:
Annalisa Murgo, Fabio Bignami, Giuseppina Federico, Gino Villetti, Maurizio Civelli, Angelo Sala, Daniela Miglietta
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, age-related interstitial lung disease (ILD) with limited therapeutic options. Despite the wide variety of different in vivo models for IPF, these preclinical models have shown
Externí odkaz:
https://doaj.org/article/af70c3d881024e42bd6f86364bd436c2
Autor:
Giorgio Aquila, Yannick Regin, Xabier Murgia, Fabrizio Salomone, Costanza Casiraghi, Chiara Catozzi, Enrica Scalera, Matteo Storti, Francesca Stretti, Giancarlo Aquino, Giorgia Cavatorta, Roberta Volta, Carmelina Di Pasquale, Caterina Amato, Fabio Bignami, Davide Amidani, Barbara Pioselli, Elisa Sgarbi, Paolo Ronchi, Giuseppe Mazzola, Ignacio Valenzuela, Jaan Toelen
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1507 (2022)
Thiazolidinediones (TZDs) are potent PPARγ agonists that have been shown to attenuate alveolar simplification after prolonged hyperoxia in term rodent models of bronchopulmonary dysplasia. However, the pulmonary outcomes of postnatal TZDs have not b
Externí odkaz:
https://doaj.org/article/3deb22c045194f439472a544de6d3be1
Autor:
Elisabetta Pilotti, Attilio Cannata, Giacomo Magnani, Fabio Bignami, Andrea Corsi, Maria Teresa Valenti, Mariam Shallak, Greta Forlani, Maria Grazia Romanelli
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 14; Pages: 7583
Despite human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 being retroviruses closely related at a genomic level, HTLV-2 differs from HTLV-1 in terms of pathogenicity in both single infection and coinfection contexts. Moreover, the HTLV-2 associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ab81a803b412d73446ea5fc6388f08
Autor:
Philippe Fonteyne, Fabio Bignami, Marco Barbariga, Paolo Rama, Giulio Ferrari, Romina Mayra Lasagni Vitar
Publikováno v:
Investigative Ophthalmology & Visual Science
PURPOSE. The purpose of this study was to test the role of substance P (SP) and its receptor neurokinin 1 (NK1R) on ocular surface pain. METHODS. Eight-week-old C57BL6/N (wild type [WT]) and B6.Cg-Tac1tm1Bbm/J (TAC1-KO) male mice were used. 5 M NaCl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0542346d919832aabf61d2d1dc13f0fe
http://europepmc.org/articles/PMC7980039
http://europepmc.org/articles/PMC7980039
Autor:
Fabio Bignami, Maurizio Civelli, Daniela Miglietta, Paola Caruso, Vanessa Pitozzi, Martina Bonatti, Marcello Trevisani, Maria Pittelli, Silvia Pontis, Gino Villetti
Publikováno v:
Mechanisms of lung injury and repair.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a082aa6c76b23c790cc4cb190329d946
https://doi.org/10.1183/13993003.congress-2019.pa2420
https://doi.org/10.1183/13993003.congress-2019.pa2420
Autor:
Giulio Ferrari, Alessandro Rabiolo, Marco Barbariga, Paolo Rama, Philippe Fonteyne, Fabio Bignami
Publikováno v:
Investigative ophthalmologyvisual science. 59(13)
Purpose Aging impairs corneal nerve density and sensitivity. Substance P (SP), a neuropeptide secreted by sensory nerves, regulates nerve morphology and nociception. Here, we investigate the relationship between aging, nerve morphology, and SP expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd3c57d28c3b6f7a0975f53e60c37f59
https://pubmed.ncbi.nlm.nih.gov/30398624
https://pubmed.ncbi.nlm.nih.gov/30398624
Autor:
Maria Pittelli, Silvia Pontis, Gino Villetti, Martina Bonatti, Costanza Lagrasta, Federico Quaini, Paola Caruso, Fabio Bignami, Caterina Frati, Maurizio Civelli, Vanessa Pitozzi, Chiara Mangiaracina, Marcello Trevisani
Publikováno v:
Mechanisms of Lung Injury and Repair.
Background & Objectives: The aim of this study was to investigate the time-course of the molecular and histological changes induced by a double intratracheal (IT) administration of bleomycin (BLM) on lung tissue. Methods: Male SD rats were injected w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76776c4f4953c2d7839350bdf571948b
https://doi.org/10.1183/13993003.congress-2018.pa1001
https://doi.org/10.1183/13993003.congress-2018.pa1001
Autor:
Gino Villetti, Chiara Carnini, Giancarlo Aquino, Fabio Bignami, Matteo Biagetti, Anna Rita Pisano, Andrew Allen, Maurizio Civelli, Daniela Miglietta
Publikováno v:
Airway pharmacology and treatment.
The JAK/STAT signalling plays a key role in both innate and adaptive immunity and it has been reported that JAK inhibition can reduce allergen-induced airway inflammation in different animal models of asthma. Here we studied the effects of the JAK in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4a4d76e97838725948cbb9a92902211
https://doi.org/10.1183/13993003.congress-2018.oa1941
https://doi.org/10.1183/13993003.congress-2018.oa1941
Publikováno v:
Eye & Contact Lens: Science & Clinical Practice. 41:72-76
The cornea is normally devoid of blood and lymphatic vessels; however, a number of infectious/inflammatory diseases can induce corneal neovascularization (CNV). Tumor necrosis factor (TNF)-α, a well known pro-inflammatory cytokine, acts on the vascu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a042fcd43ee774db23491fc3a0d4137c
https://doi.org/10.1097/icl.0000000000000071
https://doi.org/10.1097/icl.0000000000000071
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1582
HTLV Tax proteins (Tax-1 and Tax-2) are known to be able to transactivate several host cellular genes involved in complex molecular pathways. Here, we describe a stable and regulated high-level expression model based on Tet-On system, to study the ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22096c57de6d00410c462199ffececfa
https://pubmed.ncbi.nlm.nih.gov/28357664
https://pubmed.ncbi.nlm.nih.gov/28357664