Zobrazeno 1 - 10 of 55 pro vyhledávání: '"Fabio Bertozzi"'
1
Akademický článek
Combined in vivo effect of N-acylethanolamine-hydrolyzing acid amidase and glycogen synthase kinase-3β inhibition to treat multiple sclerosis
Autor: Stefania Sgroi, Elisa Romeo, Ennio Albanesi, Federica Piccardi, Federico Catalano, Doriana Debellis, Fabio Bertozzi, Angelo Reggiani
Publikováno v: Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116677- (2024)
The current pharmacological approaches to multiple sclerosis (MS) target its inflammatory and autoimmune components, but effective treatments to foster remyelination and axonal repair are still lacking. We therefore selected two targets known to be i
Externí odkaz: https://doaj.org/article/783eee76e7694739afaef1ea02669da4
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3
Akademický článek
A European regulatory perspective on cystic fibrosis: current treatments, trends in drug development and translational challenges for CFTR modulators
Autor: Stefano Ponzano, Giulia Nigrelli, Laura Fregonese, Irmgard Eichler, Fabio Bertozzi, Tiziano Bandiera, Luis J.V. Galietta, Marisa Papaluca
Publikováno v: European Respiratory Review, Vol 27, Iss 148 (2018)
In this article we analyse the current authorised treatments and trends in early drug development for cystic fibrosis (CF) in the European Union for the time period 2000–2016. The analysis indicates a significant improvement in the innovation and d
Externí odkaz: https://doaj.org/article/8f7562e309704950ac3717bf992be43f
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4
Pharmacological potentiators of the calcium signaling cascade identified by high-throughput screening
Autor: Michele Genovese, Daniela Guidone, Martina Buccirossi, Anna Borrelli, Alejandra Rodriguez-Gimeno, Fabio Bertozzi, Tiziano Bandiera, Luis J V Galietta
Publikováno v: PNAS Nexus. 2
Pharmacological modulators of the Ca2+ signaling cascade are important research tools and may translate into novel therapeutic strategies for a series of human diseases. We carried out a screening of a maximally diverse chemical library using the Ca2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4133443283bce2eb11349861530d5e5b
https://doi.org/10.1093/pnasnexus/pgac288
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8
Inhibition of N-acylethanolamine-hydrolyzing acid amidase reduces T cell infiltration in a mouse model of multiple sclerosis
Autor: Angelo Reggiani, Paolo Di Fruscia, Elisa Romeo, Pier Francesca Porceddu, Ennio Albanesi, Natalia Realini, Fabio Bertozzi, Tiziano Bandiera, Stefania Sgroi, Debora Russo
Publikováno v: Pharmacological research. 172
Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS), in which myeloid cells sustain inflammation, take part in priming, differentiation, and reactivation of myelin-specific T cells, and cause direct myelin da
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0053435a5f46576d494a236a1d57f6ae
https://pubmed.ncbi.nlm.nih.gov/34391933
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9
Partial Rescue of F508del-CFTR Stability and Trafficking Defects by Double Corrector Treatment
Autor: Arianna Venturini, Daniela Guidone, Ilaria Musante, Sine Mandrup Bertozzi, Cristina Pastorino, Valeria Tomati, Tiziano Bandiera, Nicoletta Pedemonte, Valeria Capurro, Federico Zara, Luis J. V. Galietta, Fabio Bertozzi, Anna Borrelli, Elvira Sondo, Mario Renda, Alessandro Giraudo
Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 10
International Journal of Molecular Sciences, Vol 22, Iss 5262, p 5262 (2021)
Deletion of phenylalanine at position 508 (F508del) in the CFTR chloride channel is the most frequent mutation in cystic fibrosis (CF) patients. F508del impairs the stability and folding of the CFTR protein, thus resulting in mistrafficking and prema
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2193bb07fe8f117103438fa85cec1f46
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