Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways

Autor: Naziia Kurmasheva, Aida Said, Boaz Wong, Priscilla Kinderman, Xiaoying Han, Anna H. F. Rahimic, Alena Kress, Madalina E. Carter-Timofte, Emilia Holm, Demi van der Horst, Christoph F. Kollmann, Zhenlong Liu, Chen Wang, Huy-Dung Hoang, Elina Kovalenko, Maria Chrysopoulou, Krishna Sundar Twayana, Rasmus N. Ottosen, Esben B. Svenningsen, Fabio Begnini, Anders E. Kiib, Florian E. H. Kromm, Hauke J. Weiss, Daniele Di Carlo, Michela Muscolini, Maureen Higgins, Mirte van der Heijden, Angelina Bardoul, Tong Tong, Attila Ozsvar, Wen-Hsien Hou, Vivien R. Schack, Christian K. Holm, Yunan Zheng, Melanie Ruzek, Joanna Kalucka, Laureano de la Vega, Walid A. M. Elgaher, Anders R. Korshoej, Rongtuan Lin, John Hiscott, Thomas B. Poulsen, Luke A. O’Neill, Dominic G. Roy, Markus M. Rinschen, Nadine van Montfoort, Jean-Simon Diallo, Henner F. Farin, Tommy Alain, David Olagnier

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-28 (2024)

Abstract The presence of heterogeneity in responses to oncolytic virotherapy poses a barrier to clinical effectiveness, as resistance to this treatment can occur through the inhibition of viral spread within the tumor, potentially leading to treatmen

Externí odkaz: https://doaj.org/article/cf343351f5cf4766ad351ee93729ee99

Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction

Autor: Fabio Begnini, Stefan Geschwindner, Patrik Johansson, Lisa Wissler, Richard J. Lewis, Emma Danelius, Andreas Luttens, Pierre Matricon, Jens Carlsson, Stijn Lenders, Beate König, Anna Friedel, Peter Sjö, Stefan Schiesser, Jan Kihlberg

Upregulation of the transcription factor Nrf2 by inhibition of the interaction with its negative regulator Keap1 constitutes an opportunity for the treatment of disease caused by oxidative stress. We report a structurally unique series of nanomolar K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2356a884998258f24d9f2fdfe2f58424
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-477522

Cell Permeability of Isomeric Macrocycles : Predictions and NMR Studies

Autor: Yoseph Atilaw, Stefan Schiesser, Vasanthanathan Poongavanam, Fabio Begnini, Jan Kihlberg, Máté Erdélyi

Publikováno v: ACS Medicinal Chemistry Letters

Conformation-dependent 3D descriptors have been shown to provide better predictions of the physicochemical properties of macrocycles than 2D descriptors. However, the computational identification of relevant conformations for macrocycles is nontrivia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5303ce42c9bde21d3977a5b3d3070a
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-448939

Drug Syntheses Beyond the Rule of 5

Autor: Jan Kihlberg, Bradley C. Doak, Mohit Tyagi, Fabio Begnini, Vasanthanathan Poongavanam

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 26(1)

Drugs in the chemical space beyond the rule of 5 (bRo5) can modulate targets with difficult binding sites while retaining cell permeability and oral absorption. Reviewing the syntheses of bRo5 drugs approved since 1990 highlights synthetic chemistry'

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45622b2629921f81023b06c5f6f26fca
https://pubmed.ncbi.nlm.nih.gov/31483909

Sequential Multicomponent Strategy for the Diastereoselective Synthesis of Densely Functionalized Spirooxindole-Fused Thiazolidines

Autor: Alessandra Silvani, Mariska De Munnik, Giulia Rainoldi, Fabio Begnini, Eelco Ruijter, Romano V. A. Orru, Leonardo Lo Presti, Giordano Lesma, Christophe M. L. Vande Velde

Publikováno v: Rainoldi, G, Begnini, F, De Munnik, M, Lo Presti, L, Vande Velde, C M L, Orru, R, Lesma, G, Ruijter, E & Silvani, A 2018, ' Sequential Multicomponent Strategy for the Diastereoselective Synthesis of Densely Functionalized Spirooxindole-Fused Thiazolidines ', ACS Combinatorial Science, vol. 20, no. 2, pp. 98-105 . https://doi.org/10.1021/acscombsci.7b00179
ACS combinatorial science
ACS Combinatorial Science, 20(2), 98-105. American Chemical Society

We developed two Ugi-type three-component reactions of spirooxindole-fused 3-thiazolines, isocyanides, and either carboxylic acids or trimethylsilyl azide, to give highly functionalized spirooxindole-fused thiazolidines. Two diverse libraries were ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1540f0a341547c3a4c6a7efe3aaf8f15
https://research.vu.nl/en/publications/044abadd-7ca8-4850-95b7-466d91819aed