Genome architecture and stability in the Saccharomyces cerevisiae knockout collection

Autor: Alexandra Selivanova, Rong Li, Roded Sharan, Shir Klein-Lavi, Mareike Herzog, Jin Zhu, Iñigo Ayestaran, Israel Salguero, Stephen P. Jackson, Siyue Wang, Martin Kupiec, Roi Meirman, Molly Gordon, Gonzalo Millán-Zambrano, Fabio Puddu

Publikováno v: Nature. 573:416-420

Despite major progress in defining the functional roles of genes, a complete understanding of their influences is far from being realized, even in relatively simple organisms. A major milestone in this direction arose via the completion of the yeast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::090eae16b2265900cde70e616889149e
https://doi.org/10.1038/s41586-019-1549-9

Trajectory and uniqueness of mutational signatures in yeast mutators

Autor: Fabio Puddu, Mareike Herzog, Sophie Loeillet, Stephen P. Jackson, Patricia Legoix, Alain Nicolas, Sylvain Baulande

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2020, 117 (40), pp.24947-24956. ⟨10.1073/pnas.2011332117⟩

Significance Deficiencies in genome maintenance genes result in increased mutagenesis and genome rearrangements that impact cell viability, species adaptation, and evolvability. The accumulation of somatic mutations is also a landmark of most tumor c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb67b9eb88d6b3021cf61ecb116b9ba6
https://hal.sorbonne-universite.fr/hal-02986885/file/24947.full.pdf

Dynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activity.

Autor: Magda Granata, Federico Lazzaro, Daniele Novarina, Davide Panigada, Fabio Puddu, Carla Manuela Abreu, Ramesh Kumar, Muriel Grenon, Noel F Lowndes, Paolo Plevani, Marco Muzi-Falconi

Publikováno v: PLoS Genetics, Vol 6, Iss 8 (2010)

Saccharomyces cerevisiae Rad9 is required for an effective DNA damage response throughout the cell cycle. Assembly of Rad9 on chromatin after DNA damage is promoted by histone modifications that create docking sites for Rad9 recruitment, allowing che

Externí odkaz: https://doaj.org/article/6e9ef3b94aac4ab7b9657f2dc514d0fa

Chromatin determinants impart camptothecin sensitivity

Autor: Fabio, Puddu, Israel, Salguero, Mareike, Herzog, Nicola J, Geisler, Vincenzo, Costanzo, Stephen P, Jackson

Publikováno v: EMBO Reports

Camptothecin‐induced locking of topoisomerase 1 on DNA generates a physical barrier to replication fork progression and creates topological stress. By allowing replisome rotation, absence of the Tof1/Csm3 complex promotes the conversion of impendin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9bba2dd091ceb250b900088708514b25
https://pubmed.ncbi.nlm.nih.gov/28389464

Sensing of replication stress and Mec1 activation act through two independent pathways involving the 9-1-1 complex and DNA polymerase ε

Autor: Marco Muzi-Falconi, Gabriele Piergiovanni, Fabio Puddu, Paolo Plevani

Publikováno v: PLoS Genetics, Vol 7, Iss 3, p e1002022 (2011)
PLoS Genetics

Following DNA damage or replication stress, budding yeast cells activate the Rad53 checkpoint kinase, promoting genome stability in these challenging conditions. The DNA damage and replication checkpoint pathways are partially overlapping, sharing se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d06eaf31dd3dbc3661dcf544e933c0fd
http://europepmc.org/articles/PMC3060063?pdf=render