Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Fabienne Thompson"'
Autor:
Monsif Bouaboula, Laurent Debussche, Carlos Garcia-Echeverria, Hong Cheng, Bruno Filoche-Rommé, Gary McCort, Fabienne Thompson, Victor Certal, Michel Tabart, Frank Halley, Youssef El-Ahmad, Laurent Schio, Pierre-Yves Abecassis, Dinesh S. Bangari, Anne Caron, Laurent Besret, Joon Sang Lee, Jack Pollard, Hui Cao, Rosalia Arrebola, Albane Courjaud, Dietmar Hoffmann, Mikhail N. Levit, Jessica McManus, Andrew T. Hebert, Zhuyan Guo, Malvika Koundinya, Fangxian Sun, Jane Cheng, Maysoun Shomali
1022 gene signature from RNAseq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10eddd92e318753beaf14063960214f
https://doi.org/10.1158/1535-7163.22520766
https://doi.org/10.1158/1535-7163.22520766
Autor:
Monsif Bouaboula, Laurent Debussche, Carlos Garcia-Echeverria, Hong Cheng, Bruno Filoche-Rommé, Gary McCort, Fabienne Thompson, Victor Certal, Michel Tabart, Frank Halley, Youssef El-Ahmad, Laurent Schio, Pierre-Yves Abecassis, Dinesh S. Bangari, Anne Caron, Laurent Besret, Joon Sang Lee, Jack Pollard, Hui Cao, Rosalia Arrebola, Albane Courjaud, Dietmar Hoffmann, Mikhail N. Levit, Jessica McManus, Andrew T. Hebert, Zhuyan Guo, Malvika Koundinya, Fangxian Sun, Jane Cheng, Maysoun Shomali
Primary treatment for estrogen receptor-positive (ER+) breast cancer is endocrine therapy. However, substantial evidence indicates a continued role for ER signaling in tumor progression. Selective estrogen receptor degraders (SERD), such as fulvestra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b86af78b2f4b0ea0bc017ba86b84056
https://doi.org/10.1158/1535-7163.c.6542763
https://doi.org/10.1158/1535-7163.c.6542763
Autor:
Monsif Bouaboula, Laurent Debussche, Carlos Garcia-Echeverria, Hong Cheng, Bruno Filoche-Rommé, Gary McCort, Fabienne Thompson, Victor Certal, Michel Tabart, Frank Halley, Youssef El-Ahmad, Laurent Schio, Pierre-Yves Abecassis, Dinesh S. Bangari, Anne Caron, Laurent Besret, Joon Sang Lee, Jack Pollard, Hui Cao, Rosalia Arrebola, Albane Courjaud, Dietmar Hoffmann, Mikhail N. Levit, Jessica McManus, Andrew T. Hebert, Zhuyan Guo, Malvika Koundinya, Fangxian Sun, Jane Cheng, Maysoun Shomali
supplemental methods, data and figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3813137435b6e50ede54df16b76c6dfc
https://doi.org/10.1158/1535-7163.22520769.v1
https://doi.org/10.1158/1535-7163.22520769.v1
Autor:
Chrystelle Girardet, Magali Mathieu, François Vallée, Jacques Le-Roux, Fangxian Sun, Laurence Fabien, Corinne Terrier, Celine Ginesty, Bruno Filoche-Romme, Florence Gruss-Leleu, Maysoun Shomali, Monsif Bouaboula, Sylvie Beccari, Pascal Desmazeau, Gilles Lebourg, Tsiala Benard, Victor Certal, Pascale Vicat, Andrew Hebert, Carlos Garcia-Echeverria, Laurent Schio, Youssef El-Ahmad, Gary Mccort, Claire Muller, Maurice Brollo, Mikhail Levit, Luc Bertin, Hong Cheng, Véronique Loyau, Valerie Steier, Fabienne Thompson, Audrey Louboutin, Fabienne Pilorge, Alexey Rak, Frank Halley, Patrick Richepin, Christelle Perrault, Pierre-Yves Abecassis, Michel Tabart, Albane Courjaud
Publikováno v:
Journal of Medicinal Chemistry. 63:512-528
More than 75% of breast cancers are estrogen receptor alpha (ERα) positive (ER+), and resistance to current hormone therapies occurs in one-third of ER+ patients. Tumor resistance is still ERα-dependent, but mutations usually confer constitutive ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb6b8e31876cd3009f301f509589bd98
https://doi.org/10.1021/acs.jmedchem.9b01293
https://doi.org/10.1021/acs.jmedchem.9b01293
Autor:
Youssef El-Ahmad, Hong Cheng, Fabienne Thompson, Monsif Bouaboula, Jack Pollard, Gary Mccort, Andrew Hebert, Carlos Garcia-Echeverria, Michel Tabart, Fangxian Sun, Laurent Schio, Joon Sang Lee, Dinesh S. Bangari, Jane Cheng, Laurent Besret, Hui Cao, Dietmar Hoffmann, Maysoun Shomali, Rosalia Arrebola, Zhuyan Guo, Anne Caron, Laurent Debussche, Frank Halley, Bruno Filoche-Romme, Albane Courjaud, Mikhail Levit, Malvika Koundinya, Jessica McManus, Victor Certal, Pierre-Yves Abecassis
Publikováno v:
Molecular cancer therapeutics. 20(2)
Primary treatment for estrogen receptor-positive (ER+) breast cancer is endocrine therapy. However, substantial evidence indicates a continued role for ER signaling in tumor progression. Selective estrogen receptor degraders (SERD), such as fulvestra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a793f8b26300e48375f0775740c17d0
https://pubmed.ncbi.nlm.nih.gov/33310762
https://pubmed.ncbi.nlm.nih.gov/33310762
Autor:
Maysoun Shomali, Youssef El-Ahmad, Frank Halley, Jane Cheng, Michael Weinstein, Muchun Wang, Fangxian Sun, Natalia Malkova, Mikhail Levit, Malvika Koundinya, Zhuyan Gou, Andrew Hebert, Jessica McManus, Dietmar Hoffman, Hui Cao, Joonil Jung, Jack Pollard, Sylvie Vincent, Timothy Ackerson, Francisco Adrian, Chris Winter, Victoria Richon, Hong Chen, Karl Hsu, Joanne Lager, Albane Courjaud, Rosalia Arrebola, Laurent Besret, Pierre-Yves Abecassis, Laurent Schio, Gary McCort, Michel Tabart, Victor Certal, Fabienne Thompson, Bruno Filoche-Rommé, Laurent Debussche, Patrick Cohen, Carlos Garcia-Echeverria, Monsif Bouaboula
Publikováno v:
Cancer Research. 78:5775-5775
Nearly 70% or more of newly diagnosed cases of breast cancer (BC) are estrogen receptor positive (ER+) where endocrine therapy is a primary treatment. However, substantial evidence describes a continued role of ER signaling in tumor progression, wher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a67ba81130dd15685d38e5e0aa1141af
https://doi.org/10.1158/1538-7445.am2018-5775
https://doi.org/10.1158/1538-7445.am2018-5775
Autor:
Jean Pierre Marquette, Andreas Karlsson, Sylvie Monget, Thomas Bertrand, Jean Christophe Carry, Frank Halley, Marc Antoine Perrin, Jean Paul Nicolas, Tsiala Benard, Angela Virone-Oddos, Luc Bertin, Céline Amara, Hélène Bonnevaux, Laurence Delbarre, Gilles Doerflinger, Pierre Yves Abecassis, Youssef El-Ahmad, Véronique Charrier, Victor Certal, Bruno Filoche-Romme, Florence Gruss-Leleu, Sébastien Perron, Alexey Rak, Patrick Richepin, Stephane Guerif, Carlos Garcia-Echeverria, Loic Vincent, Nadine Michot, Magali Mathieu, Véronique Loyau, Olivier Lemaitre, Maurice Brollo, Christoph Lengauer, Houlfa Guizani, Laurent Schio, Fabienne Thompson, Cécile Delorme
Publikováno v:
Journal of Medicinal Chemistry. 57:903-920
Compelling molecular biology publications have reported the implication of phosphoinositide kinase PI3Kβ in PTEN-deficient cell line growth and proliferation. These findings supported a scientific rationale for the development of PI3Kβ-specific inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c85553ea8c69d86eeaefddb3c7297b6
https://doi.org/10.1021/jm401642q
https://doi.org/10.1021/jm401642q
Autor:
Cécile Delorme, Angela Virone-Oddos, Bernadette Tric, Audrey Louboutin, Fabienne Thompson, Christoph Lengauer, Loic Vincent, Nadine Michot, Isabelle Vade, Jean Paul Nicolas, Frank Halley, Youssef El-Ahmad, Bruno Filoche-Romme, Hélène Bonnevaux, Andreas Karlsson, Sylvie Monget, Renaud Morales, Victor Certal, Laurent Schio, Gilles Doerflinger, Sébastien Perron, Jean Christophe Carry, Pierre Yves Abecassis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6381-6384
From a HTS campaign, a new series of pyrimidone anilides exemplified by compound 1 has been identified with good inhibitory activity for the PI3Kβ isoform. The structure of compound 1 in PI3Kγ was solved revealing a binding mode in agreement with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a7ad294cd6eed46f1ac36681f76724
https://doi.org/10.1016/j.bmcl.2012.08.072
https://doi.org/10.1016/j.bmcl.2012.08.072
Autor:
Jean Christophe Carry, Youssef El-Ahmad, Bruno Filoche-Romme, Frank Halley, Loic Vincent, Andreas Karlsson, Thomas Bertrand, Christoph Lengauer, Tsiala Benard, Pierre Yves Abecassis, Peter Below, Alexey Rak, Jean Paul Nicolas, Gilles Lebourg, Audrey Louboutin, Victor Certal, Laurent Schio, Cécile Delorme, Nadine Michot, Fabienne Pilorge, Fabienne Chatreaux, Pascale Lejeune, Fabienne Thompson, Angela Virone-Oddos, Isabelle Vade, Hélène Bonnevaux, Jean Pierre Marquette, Odile Angouillant-Boniface
Publikováno v:
Journal of Medicinal Chemistry. 55:4788-4805
Most of the phosphoinositide-3 kinase (PI3K) kinase inhibitors currently in clinical trials for cancer treatment exhibit pan PI3K isoform profiles. Single PI3K isoforms differentially control tumorigenesis, and PI3Kβ has emerged as the isoform invol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da44cb5e3b90d40fe34a0bb8a89c84d
https://doi.org/10.1021/jm300241b
https://doi.org/10.1021/jm300241b
Autor:
Anne Thomas, Alexandre Rohaut, Annick Parent, Norbert Dereu, Luc Bertin, Hélène Goulaouic, Rosalia Arrebola, Patrick Mailliet, Alain Dupuy, Vincent Mikol, Victor Certal, Hervé Minoux, Chantal Carrez, Fabienne Pilorge, François Vallée, Stephane Guerif, Cécile Combeau, Jean-Marie Ruxer, Alain Jouanen, Jacques Dumas, Cécile Delorme, Thierry Gouyon, Paul Ferrari, Annabelle Lamberton, Florence Fassy, Fabienne Thompson, Claudine Grepin
Publikováno v:
Journal of medicinal chemistry. 54(20)
A novel class of heat shock protein 90 (Hsp90) inhibitors was developed after a low throughput screen (LTS) of a focused library containing approximately 21K compounds selected by virtual screening. The initial [1-{3-H-imidazo[4-5-c]pyridin-2-yl}-3,4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce498d97ec879964cc10e7bb416991f
https://pubmed.ncbi.nlm.nih.gov/21972823
https://pubmed.ncbi.nlm.nih.gov/21972823