Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Fabienne Gug"'
Autor:
Déborah Tribouillard-Tanvier, Suzana Dos Reis, Fabienne Gug, Cécile Voisset, Vincent Béringue, Raimon Sabate, Ema Kikovska, Nicolas Talarek, Stéphane Bach, Chenhui Huang, Nathalie Desban, Sven J Saupe, Surachai Supattapone, Jean-Yves Thuret, Stéphane Chédin, Didier Vilette, Hervé Galons, Suparna Sanyal, Marc Blondel
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2174 (2008)
6-Aminophenanthridine (6AP) and Guanabenz (GA, a drug currently in use for the treatment of hypertension) were isolated as antiprion drugs using a yeast-based assay. These structurally unrelated molecules are also active against mammalian prion in se
Externí odkaz:
https://doaj.org/article/a5173f705cba426cb60f9b719e0de299
Autor:
Déborah Tribouillard-Tanvier, Vincent Béringue, Nathalie Desban, Fabienne Gug, Stéphane Bach, Cécile Voisset, Hervé Galons, Hubert Laude, Didier Vilette, Marc Blondel
Publikováno v:
PLoS ONE, Vol 3, Iss 4, p e1981 (2008)
BackgroundPrion-based diseases are incurable transmissible neurodegenerative disorders affecting animals and humans.Methodology/principal findingsHere we report the discovery of the in vivo antiprion activity of Guanabenz (GA), an agonist of alpha2-a
Externí odkaz:
https://doaj.org/article/8eefe3241ca1455293c7d0b0209d1fe1
Autor:
Nathalie Desban, Fabienne Gug, Hervé Galons, Cécile Voisset, Marc Blondel, Nassima Oumata, Stephane Bach, Déborah Tribouillard-Tanvier
Publikováno v:
Bioconjugate Chemistry. 21:279-288
The synthesis of affinity matrices for 6-aminophenanthridine (6AP) and 2,6-dichlorobenzylidenaminoguanidine (Guanabenz, GA), two unrelated prion inhibitors, is described. In both cases, the same simple spacer, epsilon-aminocaproylaminopentanol, was i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8e0c01a16cd992da55e53ab7b230991
https://doi.org/10.1021/bc900314n
https://doi.org/10.1021/bc900314n
Autor:
Marc Blondel, Thibault Andrieu, Vincent Béringue, Dominique Dormont, Hervé Galons, Deborah Tribouillard, Hubert Laude, Fabienne Gug, Didier Vilette, Stéphane Bach, Nathalie Desban
Publikováno v:
Biotechnology Journal
Biotechnology Journal, Wiley-VCH Verlag, 2006, 1 (1), pp.58-67. ⟨10.1002/biot.200500001⟩
Biotechnology Journal, 2006, 1 (1), pp.58-67. ⟨10.1002/biot.200500001⟩
Biotechnology Journal, Wiley-VCH Verlag, 2006, 1 (1), pp.58-67. ⟨10.1002/biot.200500001⟩
Biotechnology Journal, 2006, 1 (1), pp.58-67. ⟨10.1002/biot.200500001⟩
International audience; Prions are misfolded proteins capable of propagating their altered conformation which are commonly considered as the causative agent of transmissible spongiform encephalopathies, a class of fatal neurodegenerative diseases. Cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848bb399278f5f6bef9aeef79a28e8b7
https://doi.org/10.1002/biot.200500001
https://doi.org/10.1002/biot.200500001
Autor:
Anne-Sophie Martin, Fabienne Gug, Marc Blondel, Jean-Michel Vierfond, Hervé Galons, Stéphane Bach
Publikováno v:
Tetrahedron. 60:4705-4708
Biologically active 6-aminophenanthridines were prepared in a single step procedure: Metal amides in liquid ammonia promoted the condensation of anilines with 2-chloro-benzonitriles. 6-Aminophenanthridines were isolated in moderate yield.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9f4119b612472f6c88e84586353302
https://doi.org/10.1016/j.tet.2004.03.062
https://doi.org/10.1016/j.tet.2004.03.062
Autor:
Jean-Michel Vierfond, Serge Bouaziz, Nathalie Desban, Hervé Galons, Marc Blondel, Fabienne Gug
Publikováno v:
Tetrahedron Letters. 46:3725-3727
A simple synthesis of biologically active 6-aminophenanthridines was achieved by a Suzuki–Miyaura coupling reaction. Condensation of 2-(4,4,5,5-tetramethyl-1,3-dioxaborolan-2-yl)aniline with 2-chlorobenzonitriles afforded 6-aminophenanthridines use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c498fcc5f79b4529184e2c9357c6ca4e
https://doi.org/10.1016/j.tetlet.2005.03.135
https://doi.org/10.1016/j.tetlet.2005.03.135
Autor:
Raimon Sabaté, Chenhui Huang, Déborah Tribouillard-Tanvier, Suzana Dos Reis, Didier Vilette, Hervé Galons, Cécile Voisset, Nathalie Desban, Vincent Béringue, Marc Blondel, Suparna Sanyal, Stéphane Bach, Jean-Yves Thuret, Nicolas Talarek, Fabienne Gug, Ema Kikovska, Stéphane Chédin, Surachai Supattapone, Sven J. Saupe
Publikováno v:
PLoS ONE
PLoS ONE, Public Library of Science, 2008, 3 (5), pp.e2174. ⟨10.1371/journal.pone.0002174⟩
PLoS ONE, 2008, 3 (5), pp.e2174. ⟨10.1371/journal.pone.0002174⟩
PLoS ONE, Public Library of Science, 2008, 3 ((5)), pp.e2174
PLoS ONE, Vol 3, Iss 5, p e2174 (2008)
Plos One 5 (3), . (2008)
PLoS ONE, Public Library of Science, 2008, 3 (5), pp.e2174. ⟨10.1371/journal.pone.0002174⟩
PLoS ONE, 2008, 3 (5), pp.e2174. ⟨10.1371/journal.pone.0002174⟩
PLoS ONE, Public Library of Science, 2008, 3 ((5)), pp.e2174
PLoS ONE, Vol 3, Iss 5, p e2174 (2008)
Plos One 5 (3), . (2008)
International audience; BACKGROUND: 6-Aminophenanthridine (6AP) and Guanabenz (GA, a drug currently in use for the treatment of hypertension) were isolated as antiprion drugs using a yeast-based assay. These structurally unrelated molecules are also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e3304ea9e13c9329b3a4e632f3c323
http://doc.rero.ch/record/18086/files/tal_pfa.pdf
http://doc.rero.ch/record/18086/files/tal_pfa.pdf
Autor:
Stéphane Bach, Deborah Tribouillard, Laurent Meijer, Hervé Galons, Damien Guiffant, Marc Blondel, Fabienne Gug
Publikováno v:
Biotechnology Journal
Biotechnology Journal, Wiley-VCH Verlag, 2007, 2 (1), pp.68-75. ⟨10.1002/biot.200600223⟩
Biotechnology Journal, 2007, 2 (1), pp.68-75. ⟨10.1002/biot.200600223⟩
Biotechnology Journal, Wiley-VCH Verlag, 2007, 2 (1), pp.68-75. ⟨10.1002/biot.200600223⟩
Biotechnology Journal, 2007, 2 (1), pp.68-75. ⟨10.1002/biot.200600223⟩
Efforts to characterize small molecular weight chemical inhibitors of pharmacological interest tend to identify molecules with high efficiency and selectivity, to meet the two criteria required for the clinical development of a drug: efficacy and har
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5562aa8a1e391323e6b9dab719c0b50
https://hal.archives-ouvertes.fr/hal-00169462
https://hal.archives-ouvertes.fr/hal-00169462
Publikováno v:
Scopus-Elsevier
Europe PubMed Central
Europe PubMed Central
A number of drugs active against prions either in vitro, in cellular systems or in vivo in animal models have been isolated in various screening assays. In this minireview, we would like to suggest, that in addition to their direct interest as potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b18dce2f347f26834e436a69e11f25
https://europepmc.org/articles/PMC2633708/
https://europepmc.org/articles/PMC2633708/
Autor:
Nathalie Desban, Marc Blondel, Deborah Tribouillard, Stéphane Bach, Hervé Galons, Fabienne Gug, Nicolas Talarek
Publikováno v:
Methods
Methods, Elsevier, 2006, 39 (1), pp.72-77. ⟨10.1016/j.ymeth.2006.04.005⟩
Methods, 2006, 39 (1), pp.72-77. ⟨10.1016/j.ymeth.2006.04.005⟩
Methods, Elsevier, 2006, 39 (1), pp.72-77. ⟨10.1016/j.ymeth.2006.04.005⟩
Methods, 2006, 39 (1), pp.72-77. ⟨10.1016/j.ymeth.2006.04.005⟩
International audience; Recently, we have developped a yeast-based (Saccharomyces cerevisiae) assay to isolate drugs active against mammalian prions. The initial assumption was that mechanisms controlling prion appearance and/or propagation could be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1431eae2d1be73922776b5beccede1de
https://hal.archives-ouvertes.fr/hal-02134947/document
https://hal.archives-ouvertes.fr/hal-02134947/document