Electron paramagnetic resonance highlights that the oxygen effect contributes to the radiosensitizing effect of paclitaxel.

Autor: Fabienne Danhier, Pierre Danhier, Nicolas Magotteaux, Géraldine De Preter, Bernard Ucakar, Oussama Karroum, Bénédicte Jordan, Bernard Gallez, Véronique Préat

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e40772 (2012)

BACKGROUND: Paclitaxel (PTX) is a potent anti-cancer chemotherapeutic agent and is widely used in the treatments of solid tumors, particularly of the breast and ovaries. An effective and safe micellar formulation of PTX was used to administer higher

Externí odkaz: https://doaj.org/article/6c2fc95f033647f5968e4dac4dc873e4

Magnetic targeting of paclitaxel-loaded poly(lactic-co-glycolic acid)-based nanoparticles for the treatment of glioblastoma

Autor: Lakshmi Pallavi Ganipineni, Véronique Préat, Nicolas Joudiou, Bernard Ucakar, John Bianco, Bernard Gallez, Pierre Danhier, Mengnan Zhao, Chiara Bastiancich, Fabienne Danhier

Publikováno v: International Journal of Nanomedicine. 13:4509-4521

Introduction Glioblastoma (GBM) therapy is highly challenging, as the tumors are very aggressive due to infiltration into the surrounding normal brain tissue. Even a combination of the available therapeutic regimens may not debulk the tumor completel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef76f1b442dcaeffc6579228eac22b1b
https://doi.org/10.2147/ijn.s165184

Drug combination using an injectable nanomedicine hydrogel for glioblastoma treatment

Autor: Véronique Préat, Chiara Bastiancich, Elia Bozzato, Urszula Luyten, Guillaume Bastiat, Fabienne Danhier

Publikováno v: International Journal of Pharmaceutics
International Journal of Pharmaceutics, Elsevier, 2019, 559, pp.220-227. ⟨10.1016/j.ijpharm.2019.01.042⟩
International Journal of Pharmaceutics, Vol. 559, p. 220-227 (2019)

Lauroyl-gemcitabine lipid nanocapsules (GemC12-LNC) hydrogel, administered intratumorally or perisurgically in the tumor resection cavity, increases animal survival in several orthotopic GBM models. We hypothesized that GemC12-LNC can be used as nano

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4404f2f86d425a4b8e1c011f25018081
https://hdl.handle.net/2318/1879912

Evaluation of lauroyl-gemcitabine-loaded hydrogel efficacy in glioblastoma rat models

Autor: Laurent Lemaire, Véronique Préat, Guillaume Bastiat, Florence Franconi, Frédéric Lagarce, Fabienne Danhier, John Bianco, Chiara Bastiancich

Publikováno v: Nanomedicine
Nanomedicine, Future Medicine, 2018, 13 (16), pp.1999-2013. ⟨10.2217/nnm-2018-0057⟩
Nanomedicine, 2018, 13 (16), pp.1999-2013. ⟨10.2217/nnm-2018-0057⟩

Aim Anticancer drug-loaded hydrogels are a promising strategy for the local treatment of incurable brain tumors such as glioblastoma (GBM). Recently, we demonstrated the efficacy of lauroyl-gemcitabine lipid nanocapsule hydrogel (GemC12-LNC) in a U-8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358e2e6a9273b9e3de30b48f7eb61a01
https://hal.archives-ouvertes.fr/hal-02076753

Drug delivery challenges and future of chemotherapeutic nanomedicine for glioblastoma treatment

Autor: Fabienne Danhier, Lakshmi Pallavi Ganipineni, Véronique Préat

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 281

Glioblastoma (GBM) is one of the most aggressive and deadliest central nervous system tumors, and the current standard treatment is surgery followed by radiotherapy with concurrent chemotherapy. Nevertheless, the survival period is notably low. Altho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16704570b9626f4f2df136e4b85c6f17
https://pubmed.ncbi.nlm.nih.gov/29753958