Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Fabienne Beuron"'
Autor:
Rosalind Graham, Patrycja Gazinska, Birong Zhang, Atousa Khiabany, Shubhankar Sinha, Thanussuyah Alaguthurai, Fabian Flores-Borja, Jose Vicencio, Fabienne Beuron, Ioannis Roxanis, Rafal Matkowski, Revadee Liam-Or, Andrew Tutt, Tony Ng, Khuloud T. Al-Jamal, You Zhou, Sheeba Irshad
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundIntracellular communication within the tumour is complex and extracellular vesicles (EVs) have been identified as major contributing factors for the cell-to-cell communication in the local and distant tumour environments. Here, we examine t
Externí odkaz:
https://doaj.org/article/6751835215264410a344fd60c77e7254
Autor:
Marios G. Koliopoulos, Reyhan Muhammad, Theodoros I. Roumeliotis, Fabienne Beuron, Jyoti S. Choudhary, Claudio Alfieri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The MuvB family of protein complexes regulate cell cycle-dependent transcription, and MuvB in complex with the transcription factors B-MYB and FOXM1 activate mitotic genes during G2. Here the authors present cryo-EM data of a MuvB:B-MYB (MMB) complex
Externí odkaz:
https://doaj.org/article/8b56dd3cc673429595aaed1b8b6804d1
Autor:
Guillermo Abascal-Palacios, Laura Jochem, Carlos Pla-Prats, Fabienne Beuron, Alessandro Vannini
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Ty3 retrotransposon integrates with an exquisite specificity upstream of RNA Polymerase III-transcribed genes, such as transfer RNAs. Here the authors resolve a cryo-EM structure of an active Ty3 intasome in complex with a TFIIIB-bound tRNA promoter,
Externí odkaz:
https://doaj.org/article/bf7b6a981a694ea8b4a21cd408b7a073
Autor:
Ewan Phillip Ramsay, Guillermo Abascal-Palacios, Julia L. Daiß, Helen King, Jerome Gouge, Michael Pilsl, Fabienne Beuron, Edward Morris, Philip Gunkel, Christoph Engel, Alessandro Vannini
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
The eukaryotic RNA Polymerase III transcribes tRNAs, some ribosomal and spliceosomal RNAs. Here, the authors resolve a cryo-EM structure of human RNA Polymerase III in its apo form and complemented it with crystal structures and SAXS analysis of RPC5
Externí odkaz:
https://doaj.org/article/addf731bc84249d4a4c0c47a0f5420f5
Autor:
Morgan Jones, Fabienne Beuron, Aaron Borg, Andrea Nans, Christopher P. Earl, David C. Briggs, Ambrosius P. Snijders, Maureen Bowles, Edward P. Morris, Mark Linch, Neil Q. McDonald
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The endonuclease XPF-ERCC1 is a key component of the repair machinery to process both intra-strand and inter-strand DNA crosslinks. Here the authors present the cryo-EM structures of DNA-free and DNA-bound human XPF-ERCC1 and find that DNA-free XPF-E
Externí odkaz:
https://doaj.org/article/92077ba79c5f4633a25574477d6776b9
Autor:
Marios G. Koliopoulos, Reyhan Muhammad, Theodoros I. Roumeliotis, Fabienne Beuron, Jyoti S. Choudhary, Claudio Alfieri
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/b52c2a8e534f41ce98fab7e2b1589edc
Autor:
Sarah V. Faull, Andy M. C. Lau, Chloe Martens, Zainab Ahdash, Kjetil Hansen, Hugo Yebenes, Carla Schmidt, Fabienne Beuron, Nora B. Cronin, Edward P. Morris, Argyris Politis
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The COP9 signalosome (CSN) regulates Cullin-RING Ligase 2 (CRL2) but the molecular basis for their interaction is unknown. Here the authors use structural mass spectrometry and cryo-EM approaches to assess the structures and dynamics of CSN-CRL2 comp
Externí odkaz:
https://doaj.org/article/763dbdaeaef24615aa8b9632161a84b5
Autor:
Kerry M. Goodman, Svend Kjær, Fabienne Beuron, Phillip P. Knowles, Agata Nawrotek, Emily M. Burns, Andrew G. Purkiss, Roger George, Massimo Santoro, Edward P. Morris, Neil Q. McDonald
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1894-1904 (2014)
The RET receptor tyrosine kinase is essential to vertebrate development and implicated in multiple human diseases. RET binds a cell surface bipartite ligand comprising a GDNF family ligand and a GFRα coreceptor, resulting in RET transmembrane signal
Externí odkaz:
https://doaj.org/article/e0fc25a58f5a44f0a8e9b565c5efa8fc
Autor:
Gudrun Bachmann, Mark W. Richards, Anja Winter, Fabienne Beuron, Edward Morris, Richard Bayliss
Publikováno v:
Open Biology, Vol 6, Iss 4 (2016)
The protease separase plays a key role in sister chromatid disjunction and centriole disengagement. To maintain genomic stability, separase activity is strictly regulated by binding of an inhibitory protein, securin. Despite its central role in cell
Externí odkaz:
https://doaj.org/article/871465ee0c504195abea4d52fe0931b2
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58463 (2013)
The retinoblastoma susceptibility protein RB1 is a key regulator of cell proliferation and fate. RB1 operates through nucleating the formation of multi-component protein complexes involved in the regulation of gene transcription, chromatin structure
Externí odkaz:
https://doaj.org/article/2aab6e6b2e564bac8a760624e0f3f00a