Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Fabienne Andris"'
Autor:
Marie Le Moine, Abdulkader Azouz, Guillem Sanchez Sanchez, Solange Dejolier, Muriel Nguyen, Séverine Thomas, Valdrin Shala, Hacene Dreidi, Sébastien Denanglaire, Frédérick Libert, David Vermijlen, Fabienne Andris, Stanislas Goriely
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112876- (2023)
Summary: The co-inhibitory programmed death (PD)-1 signaling pathway plays a major role in the context of tumor-specific T cell responses. Conversely, it also contributes to the maintenance of peripheral tolerance, as patients receiving anti-PD-1 tre
Externí odkaz:
https://doaj.org/article/b082a4b6d11f4acfb5dc137c34148778
Autor:
Anouk Lepez, Tiphène Pirnay, Sébastien Denanglaire, David Perez-Morga, Marjorie Vermeersch, Oberdan Leo, Fabienne Andris
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract The AMP-activated kinase (AMPK) is a major energy sensor metabolic enzyme that is activated early during T cell immune responses but its role in the generation of effector T cells is still controversial. Using both in vitro and in vivo model
Externí odkaz:
https://doaj.org/article/9c385a8aea9048439529ca4cda5d6ca6
Autor:
Yousra Ajouaou, Abdulkader Azouz, Anaëlle Taquin, Sebastien Denanglaire, Hind Hussein, Mohammad Krayem, Fabienne Andris, Muriel Moser, Stanislas Goriely, Oberdan Leo
Publikováno v:
eLife, Vol 11 (2022)
The oxygen sensor prolyl hydroxylase domain 2 (PHD2) plays an important role in cell hypoxia adaptation by regulating the stability of HIF proteins (HIF1α and HIF2α) in numerous cell types, including T lymphocytes. The role of oxygen sensor on immu
Externí odkaz:
https://doaj.org/article/e1604c71c55a4360ab2ff987bcb3196f
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Beyond its well-admitted role in development and organogenesis, it is now clear that the transcription factor c-Maf has owned its place in the realm of immune-related transcription factors. Formerly introduced solely as a Th2 transcription factor, th
Externí odkaz:
https://doaj.org/article/c9bf6488e64c4892b12a1b7b6e365c96
Autor:
Hind Hussein, Sébastien Denanglaire, Frédéric Van Gool, Abdulkader Azouz, Yousra Ajouaou, Hana El-Khatib, Guillaume Oldenhove, Oberdan Leo, Fabienne Andris
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
RORγt-expressing Tregs form a specialized subset of intestinal CD4+ Foxp3+ cells which is essential to maintain gut homeostasis and tolerance to commensal microbiota. Recently, c-Maf emerged as a critical factor in the regulation of RORγt expressio
Externí odkaz:
https://doaj.org/article/5b6f4b76b978471a84b84521bf3b3619
Autor:
Fabienne Andris, Sébastien Denanglaire, Maelle Anciaux, Mélanie Hercor, Hind Hussein, Oberdan Leo
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Follicular helper T cells (Tfh) have been identified as the primary cell subpopulation regulating B cell responses in germinal centers, thus supporting high-affinity antibody production. Among the transcription factors orchestrating Tfh cell differen
Externí odkaz:
https://doaj.org/article/d750791585f340e597518480782efe4a
Autor:
Cécile Onclinx, Sophie Dogne, Laurence Jadin, Fabienne Andris, Christian Grandfils, François Jouret, François Mullier, Bruno Flamion
Publikováno v:
Haematologica, Vol 100, Iss 8 (2015)
Hyaluronan is a major component of the extracellular matrix and glycocalyx. Its main somatic degrading enzymes are hyaluronidases 1 and 2, neither of which is active in the bloodstream. We generated hyaluronidase 2-deficient mice. These animals suffe
Externí odkaz:
https://doaj.org/article/d85b9fa8e9a84130a5c85bc0c4aa4a13
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/140990b8da46449e892cd2eec15d5ad9
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84415 (2013)
Follicular T helper cells (Tfh) are crucial for effective antibody responses and long term T cell-dependent humoral immunity. Although many studies are devoted to this novel T helper cell population, the molecular mechanisms governing Tfh cell differ
Externí odkaz:
https://doaj.org/article/82210bf8720241069b6cf2bc9bbd779a
Autor:
Laurence Lecordier, Benoit Vanhollebeke, Philippe Poelvoorde, Patricia Tebabi, Françoise Paturiaux-Hanocq, Fabienne Andris, Laurence Lins, Etienne Pays
Publikováno v:
PLoS Pathogens, Vol 5, Iss 12, p e1000685 (2009)
Apolipoprotein L-I (apoL1) is a human-specific serum protein that kills Trypanosoma brucei through ionic pore formation in endosomal membranes of the parasite. The T. brucei subspecies rhodesiense and gambiense resist this lytic activity and can infe
Externí odkaz:
https://doaj.org/article/d66f838f76254f2295276b1865b12a8f