Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Fabien Schweighoffer"'
Autor:
Aurelie Rayer, Laurent Desire, Jérôme Bourdin, Nadia Loiseau, Maryline Marcade, Fabien Schweighoffer, Dominique Drouin, Hélène Peillon
Publikováno v:
Journal of Neurochemistry. 106:392-404
Pharmacological modulation of the GABA(A) receptor has gained increasing attention as a potential treatment for central processes affected in Alzheimer disease (AD), including neuronal survival and cognition. The proteolytic cleavage of the amyloid p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8300405e2ceab96604f12cb4b129c8c7
https://doi.org/10.1111/j.1471-4159.2008.05396.x
https://doi.org/10.1111/j.1471-4159.2008.05396.x
Autor:
Thierry Taverne, Nadia Loiseau, Sandrine Lacombe, Eric Beausoleil, Laurent Desire, Hélène Peillon, Virginie Picard, Bertrand Leblond, Dominique Drouin, Fabien Schweighoffer, Florence Bachelot, Jérôme Bourdin, Catherine De Oliveira
Publikováno v:
Journal of Biological Chemistry. 280:37516-37525
beta-Amyloid peptides (Abeta) that form the senile plaques of Alzheimer disease consist mainly of 40- and 42-amino acid (Abeta 40 and Abeta 42) peptides generated from the cleavage of the amyloid precursor protein (APP). Generation of Abeta involves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e17fb36c221681fcfee7f6f4bcceedcf
https://doi.org/10.1074/jbc.m507913200
https://doi.org/10.1074/jbc.m507913200
Publikováno v:
European Journal of Biochemistry. 271:2584-2592
A novel hypoxically regulated intercellular junction protein (claudin-like protein of 24 kDa, CLP24) has been identified that shows homology to the myelin protein 22/epithelial membrane protein 1/claudin family of cell junction proteins, which are in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60024a303a1437c766a423ac020ddee9
https://doi.org/10.1111/j.1432-1033.2004.04186.x
https://doi.org/10.1111/j.1432-1033.2004.04186.x
Autor:
Jean-Luc Teillaud, Claude Caron de Fromentel, Marie-Noëlle Mary, Emmanuel Conseiller, Nadège Gruel, Laurent Bracco, Bruno Tocque, Corinne Venot, Fabien Schweighoffer, Laurent Debussche, Olivier Cochet
Publikováno v:
Oncogene. 18:559-564
The design of conditional gene expression systems restricted to given tissues or cellular types is an important issue of gene therapy. Systems based on the targeting of molecules characteristic of the pathological state of tissues would be of interes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85552ed86e1ed89012d3bdb813159633
https://doi.org/10.1038/sj.onc.1202377
https://doi.org/10.1038/sj.onc.1202377
Autor:
Jean-Luc Teillaud, M. Kenigsberg, Isabelle Delumeau, Olivier Cochet, Fabien Schweighoffer, Marc Duchesne, Bruno Tocque
Publikováno v:
Molecular Immunology. 35:1097-1110
A rat single-chain Fv (Y238 scFv) was derived from the Y13-238 monoclonal antibody, a non-neutralizing anti-Ras antibody. The Y13-238 hybridoma expresses two functional light chains. N-terminus microsequencing of these chains showed the presence of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d37e409033effeac6a96a579791f700
https://doi.org/10.1016/s0161-5890(98)00105-9
https://doi.org/10.1016/s0161-5890(98)00105-9
Autor:
Fabien Schweighoffer, Rosa M. Rios, Sonia Barroso, Francisco Ramos-Morales, Carlos Infante, José Antonio Pintor-Toro, Bruno Tocque, María Tortolero, África Domínguez
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Grb3-3 is an isoform of Grb2, thought to arise by alternative splicing, that lacks a functional SH2 domain but retains functional SH3 domains, which allow interaction with other proteins through binding to prolinerich sequences. Several evidences sug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5172c1e4c4967f41ecc01de7c8a87b4f
https://doi.org/10.1006/bbrc.1997.7221
https://doi.org/10.1006/bbrc.1997.7221
Autor:
Marie-Christine Multon, Isabelle Delumeau, Bruno Tocque, Fabien Schweighoffer, Fabienne Parker, Florence Maurier
Publikováno v:
Cellular Signalling. 9:153-158
One attractive candidate for a Ras effector protein, other than the Raf kinases, is Ras-GAP. Indeed, recent literature suggests that besides the Raf/MAP kinase cascade, additional pathways must be stimulated to elicit a full biological response to Ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c1f803599947f74cb2cc21e9acb2f0
https://doi.org/10.1016/s0898-6568(96)00135-0
https://doi.org/10.1016/s0898-6568(96)00135-0
Autor:
Florence Maurier, Marc Duchesne, Estelle Guitard, Fabien Schweighoffer, Bruno Tocque, Isabelle Barlat
Publikováno v:
Journal of Biological Chemistry. 272:3129-3132
Sam68 is the main tyrosine-phosphorylated and Src-associated protein in mitotic cells. Sam68 exhibits a conserved functional KH (hnRNPK homology) RNA binding domain and binds single strand nucleic acids. Tyrosine phosphorylation mediates the interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ace70aa1b6ad24ee0cf20ba3d300fe9
https://doi.org/10.1074/jbc.272.6.3129
https://doi.org/10.1074/jbc.272.6.3129
Autor:
Bruno Tocque, Marc Duchesne, I. Fath, Isabelle Rey, Fabien Schweighoffer, J. Boiziau, Marie-Christine Multon
Publikováno v:
Science. 264:971-974
Growth factor receptor-bound protein 2 (Grb2) links tyrosine-phosphorylated proteins to a guanine nucleotide releasing factor of the son of sevenless (Sos) class by attaching to the former by its Src homology 2 (SH2) moiety and to the latter by its S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d213c90602961fb7def0931d1ff8298b
https://doi.org/10.1126/science.8178156
https://doi.org/10.1126/science.8178156
Autor:
I. Fath, Fabien Schweighoffer, Marc Duchesne, Isabelle Barlat, Chevallier-Multon Mc, Bruno Tocque, N Baudouy
Publikováno v:
Journal of Biological Chemistry. 268:11113-11118
The best characterized yeast guanine nucleotide releasing factor is CDC25, which acts on RAS and thereby stimulates cAMP production in Saccharomyces cerevisiae. In order to determine if CDC25 could be a specific GDP-GTP releasing factor for the mamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0529819d13350363953df0d2a4236eff
https://doi.org/10.1016/s0021-9258(18)82099-3
https://doi.org/10.1016/s0021-9258(18)82099-3