Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Fabien Melchiore"'
Autor:
Shamin Li, Fabien Melchiore, Chahrazade Kantari-Mimoun, Aurore Mouton, Samantha Knockaert, Wendy Philippon, Benjamin Chanrion, Christophe Bourgeois, Céline Lefebvre, Jamila Elhmouzi-Younes, Véronique Blanc, Fernando Ramon Olayo, Bruno Laugel
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The success of cancer immunotherapies such as immune checkpoint inhibitors, CAR T-cells and immune cell engagers have provided clinicians with tools to bypass some of the limitations of cancer immunity. However, numerous tumour factors curtail the im
Externí odkaz:
https://doaj.org/article/f077140e624c4dffa6743541f972e6ea
Autor:
Klaus Seedorf, Csaba Weber, Cedric Vinson, Sylvie Berger, Laurent-Michel Vuillard, Arpad Kiss, Stephanie Creusot, Olivier Broux, Anne Geant, Catherine Ilic, Karine Lemaitre, Johann Richard, Adel Hammoutene, Julien Mahieux, Virginie Martiny, Didier Durand, Fabien Melchiore, Miklos Nyerges, Valerie Paradis, Nicolas Provost, Valérie Duvivier, Philippe Delerive
Publikováno v:
JHEP Reports, Vol 5, Iss 4, Pp 100651- (2023)
Background & Aims: Oxidative stress is recognized as a major driver of non-alcoholic steatohepatitis (NASH) progression. The transcription factor NRF2 and its negative regulator KEAP1 are master regulators of redox, metabolic and protein homeostasis,
Externí odkaz:
https://doaj.org/article/7430d7109ccc497e953400e0d8e23dfb
Autor:
James A. H. Murray, Fabien Melchiore, Natalia Matassova, C. Pedder, Frédéric Colland, Catherine Chang, Levente Ondi, Laura C. A. Galbraith, Pawel Dokurno, Andrew W. Roberts, Chris D. Riffkin, Nolwen Guigal-Stephan, Proszenyák Ágnes, John A. Hickman, Andreas Strasser, Aurélie Studeny, Gaëlle Lysiak-Auvity, András Kotschy, Gemma L. Kelly, Fabienne Gravé, Ghislaine Guasconi, Brandon J. Aubrey, Attila Paczal, Julia Smith, Szlávik Zoltán, Gabor Radics, Brian Lockhart, David C.S. Huang, Maïa Chanrion, Gaëtane Le Toumelin-Braizat, Jia-Nan Gong, Nicolas Cauquil, Szabolcs Sipos, Alan P. Robertson, Giovanna Pomilio, James Edward Paul Davidson, Zoltán B. Szabó, Ana Leticia Maragno, Chris Graham, Marco J Herold, Gábor Blasko, Margs S. Brennan, Anne-Marie Girard, Allan E. Surgenor, Andrew H. Wei, Csékei Márton, Olivier Geneste, Chen I-Jen, Alain Bruno, David J. Segal, Guillaume Lessene, Balázs Bálint, Donia M Moujalled
Publikováno v:
Nature. 538:477-482
Avoidance of apoptosis is critical for the development and sustained growth of tumours. The pro-survival protein myeloid cell leukemia 1 (MCL1) is overexpressed in many cancers, but the development of small molecules targeting this protein that are a