Zobrazeno 1 - 10 of 41 pro vyhledávání: '"Fabien Massicot"'
1
High-Pressure Activation to Circumvent Product Degradation in the Reaction of Unprotected Glyconitrones with Alkynes
Autor: Jean-Bernard Behr, Nathan Noël, Gatien Messire, Fabien Massicot, Jean-Luc Vasse
Publikováno v: Synthesis. 55:1285-1297
Cycloadditions of nitrones with alkynes usually occur best under heat activation. Due to the instability of the formed isoxazolines, alternative activation methods must be found. Here, hyperbaric conditions are used to transform nitrones generated fr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7b497149a08344660019e6df306f80a
https://doi.org/10.1055/a-1975-5291
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3
Irreversible Inhibition of IspG, a Target for the Development of New Antimicrobials, by a 2‐Vinyl Analogue of its MEcPP Substrate
Autor: Vivien Herrscher, Clea Witjaksono, Marie Buchotte, Claire Ferret, Fabien Massicot, Jean‐Luc Vasse, Franck Borel, Jean‐Bernard Behr, Myriam Seemann
Publikováno v: Chemistry – A European Journal. 28
IspG (also called GcpE) is an oxygen-sensitive [4Fe-4S] enzyme catalyzing the penultimate step of the methylerythritol phosphate (MEP) pathway, a validated target for drug development. It converts 2-C-methyl-d-erythritol-2,4-cyclo-diphosphate (MEcPP)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622b69fde953aaa631bc96201ee2e149
https://doi.org/10.1002/chem.202200241
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4
Broadening the reaction scope of unprotected aldosesviatheir corresponding nitrones: 1,3-dipolar cycloadditions with alkenes
Autor: Jean-Luc Vasse, Emmanuel Riguet, Laura Pascual, Fabien Massicot, Gatien Messire, Jean-Bernard Behr
Publikováno v: Organic & Biomolecular Chemistry. 18:5708-5725
Condensation reactions of unprotected tetroses and pentoses with hydroxylamines afforded nitrones, which were easily converted to densely functionalized isoxazolidines in the presence of electron-poor alkenes. The 1,3-dipolar cycloaddition occurred w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d55102c964faae400e2ed58dd1191a
https://doi.org/10.1039/d0ob01350a
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6
Regiospecific formation of sugar-derived ketonitrone towards unconventional C-branched pyrrolizidines and indolizidines
Autor: Alexis Vallée, Jean-Luc Vasse, Jean-Bernard Behr, Sandrine Py, Fabien Massicot, Gatien Messire
Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2019, 17 (29), pp.7066-7077. ⟨10.1039/c9ob01419e⟩
International audience; The synthesis of unprecedented branched pyrrolizidines and indolizidines was accomplished via nitrone chemistry. The required ketonitrone, a known intermediate usually obtained as a mixture of regioisomers, was prepared in a p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ecbed89bcd5fac9da5d3e507a993e5e
https://doi.org/10.1039/c9ob01419e
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7
Tuning the Regioselective Functionalization of Trifluoromethylated Dienes via Lanthanum‐Mediated Single C−F Bond Activation
Autor: Yan Yang, Fabien Massicot, Marc Taillefer, Florian Jaroschik, Yassir Zaid, Dominique Harakat, Elodie Rousset, Laurent Maron, Sirine Sghaier, Jean-Bernard Behr, Tarun Kumar, Agathe Martinez, Xavier Le Goff
Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, 2021, 27 (12), pp.4016-4021. ⟨10.1002/chem.202005239⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2021, 27 (12), pp.4016-4021. ⟨10.1002/chem.202005239⟩
International audience; The development of new fluorine-containing building blocks and their efficient synthetic access is currently a challenging research field. Herein, the highly regio- and stereoselective addition of a large range of aldehydes on
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31054dc0dc3b2401a048132899d64726
https://hal.science/hal-03264465/document
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8
Homoallylic amines as efficient chiral inducing frameworks in the conjugate addition of amides to α,β-unsaturated esters. An entry to enantio-enriched diversely substituted amines
Autor: Lilia Anani, Aurélien Coelho, Fabien Massicot, Johann Rogier, Jean-Bernard Behr, Jean-Luc Vasse, Carine Machado-Rodrigues
Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2020, 18, pp.2632-2636. ⟨10.1039/D0OB00034E⟩
International audience; The diastereoselective conjugate addition of secondary homoallylamines, obtained in the enantioenriched form via allylmetallation of imines, to α,β-unsaturated esters is reported. This method allows access to valuable buildi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a29b54931bc16132ecc3d6a866f8d1
https://hal.archives-ouvertes.fr/hal-02880270
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9
Synthesis and glycosidase inhibition potency of all- trans substituted 1- C -perfluoroalkyl iminosugars
Autor: Richard Plantier-Royon, Fabien Massicot, Jean-Luc Vasse, Jean-Bernard Behr
Publikováno v: Carbohydrate Research
Carbohydrate Research, Elsevier, 2018, 464, pp.2-7. ⟨10.1016/j.carres.2018.05.004⟩
International audience; Synthetic analogues of the naturally occurring iminosugar homoDMDP, which feature a perfluoroalkyl group at the pseudo-anomeric position, have been synthesized from the corresponding sugar-derived cyclic aldonitrone. The new f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ef718c853437091884cb56bf66ef12
https://doi.org/10.1016/j.carres.2018.05.004
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10
Synthesis, Characterization and Reactivity of Formal 20 Electron Zirconocene-Pentafulvene Complexes
Autor: Marc Schmidtmann, Florian Jaroschik, Manfred Penkhues, Emmanuel Nicolas, Radhakrishnan Kokkuvayil Vasu, Malte Fischer, Dominique Harakat, Agathe Martinez, Jean-Luc Vasse, Fabien Massicot, Rüdiger Beckhaus, Bernard Bahlmann
Publikováno v: Organometallics
Organometallics, American Chemical Society, 2017, 36 (10), pp.2004-2013. ⟨10.1021/acs.organomet.7b00213⟩
International audience; The reaction of low-valent zirconocene reagents formedeither from the Negishi reagent Cp2Zr(n-butyl)2 or from the reduction ofCp2ZrCl2 with Mg with various pentafulvenes yielded the firstzirconocene−pentafulvene complexes, C
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0245d107ab79ba904d983a8c5792aee7
https://doi.org/10.1021/acs.organomet.7b00213
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