Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Fabien Llambi"'
Autor:
Alexis Martinez, Cristian M. Lamaizon, Cristian Valls, Fabien Llambi, Nancy Leal, Patrick Fitzgerald, Cliff Guy, Marcin M. Kamiński, Nibaldo C. Inestrosa, Brigitte van Zundert, Gonzalo I. Cancino, Andrés E. Dulcey, Silvana Zanlungo, Juan J. Marugan, Claudio Hetz, Douglas R. Green, Alejandra R. Alvarez
Publikováno v:
Antioxidants, Vol 12, Iss 11, p 2007 (2023)
The endoplasmic reticulum is a subcellular organelle key in the control of synthesis, folding, and sorting of proteins. Under endoplasmic reticulum stress, an adaptative unfolded protein response is activated; however, if this activation is prolonged
Externí odkaz:
https://doaj.org/article/52442aebd7684326868078bfe18e45e8
Autor:
Giovanni Quarato, Fabien Llambi, Cliff S. Guy, Jaeki Min, Marisa Actis, Huan Sun, Shilpa Narina, Shondra M. Pruett-Miller, Junmin Peng, Zoran Rankovic, Douglas R. Green
Publikováno v:
Cell Death Differ
The ability of mitochondria to buffer a rapid rise in cytosolic Ca(2+) is a hallmark of proper cell homeostasis. Here, we employed m-3M3FBS, a putative phospholipase C (PLC) agonist, to explore the relationships between intracellular Ca(2+) imbalance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab54d66980d55325eacebf630dd38416
https://doi.org/10.1038/s41418-022-01025-9
https://doi.org/10.1038/s41418-022-01025-9
Autor:
Jochen H.M. Prehn, Heinrich J. Huber, Douglas R. Green, Suzanne Hector, Elaine W. Kay, Frank Murray, Deborah A. McNamara, Joan Kehoe, Karen Boland, Deborah Ryan, Fabien Llambi, Mary D. Cannon, Gerhardt J. Boukes, Caoimhín G. Concannon, Andreas U. Lindner
PDF file - 66K, Temporal protein profiles for HeLa cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b189d3e810ceafc43ebc78889248b659
https://doi.org/10.1158/0008-5472.22399179
https://doi.org/10.1158/0008-5472.22399179
Autor:
Jochen H.M. Prehn, Heinrich J. Huber, Douglas R. Green, Suzanne Hector, Elaine W. Kay, Frank Murray, Deborah A. McNamara, Joan Kehoe, Karen Boland, Deborah Ryan, Fabien Llambi, Mary D. Cannon, Gerhardt J. Boukes, Caoimhín G. Concannon, Andreas U. Lindner
PDF file - 53K, Temporal protein profiles for HCT-116 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749a5e65e13ffae8d959c3e85c1b4481
https://doi.org/10.1158/0008-5472.22399176.v1
https://doi.org/10.1158/0008-5472.22399176.v1
Autor:
Jochen H.M. Prehn, Heinrich J. Huber, Douglas R. Green, Suzanne Hector, Elaine W. Kay, Frank Murray, Deborah A. McNamara, Joan Kehoe, Karen Boland, Deborah Ryan, Fabien Llambi, Mary D. Cannon, Gerhardt J. Boukes, Caoimhín G. Concannon, Andreas U. Lindner
PDF file - 237K, Supplementary Table 1: Translation of protein interactions into Ordinary Differential Equations. Supplementary Table 2: Pseudo-reactions for degradation and degradation rates as used in the model. Supplementary Table 3: Pseudo-reacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d8544002f138be36db9e0356b6ba94
https://doi.org/10.1158/0008-5472.22399170.v1
https://doi.org/10.1158/0008-5472.22399170.v1
Autor:
Jochen H.M. Prehn, Heinrich J. Huber, Douglas R. Green, Suzanne Hector, Elaine W. Kay, Frank Murray, Deborah A. McNamara, Joan Kehoe, Karen Boland, Deborah Ryan, Fabien Llambi, Mary D. Cannon, Gerhardt J. Boukes, Caoimhín G. Concannon, Andreas U. Lindner
PDF file - 52K, Systems modeling can act as a clinical tool to determine therapeutic windows and to assess adjuvant treatments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d0cd6af1762a0562109f89bc9773a1
https://doi.org/10.1158/0008-5472.22399173.v1
https://doi.org/10.1158/0008-5472.22399173.v1
Autor:
Giovanni, Quarato, Fabien, Llambi, Cliff S, Guy, Jaeki, Min, Marisa, Actis, Huan, Sun, Shilpa, Narina, Shondra M, Pruett-Miller, Junmin, Peng, Zoran, Rankovic, Douglas R, Green
Publikováno v:
Cell Death Differ
The ability of mitochondria to buffer a rapid rise in cytosolic Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::05c9cc8d2035082a50a1ac27b1289012
https://pubmed.ncbi.nlm.nih.gov/35831625
https://pubmed.ncbi.nlm.nih.gov/35831625
Autor:
Yong Yao, Aaron H. Phillips, Ariele Viacava Follis, Douglas R. Green, Cheon-Gil Park, Francesca M. Marassi, Richard W. Kriwacki, Halime Kalkavan, Fabien Llambi
Publikováno v:
Nature chemical biology
Intrinsically disordered regions (IDRs) of proteins often regulate function upon posttranslational modifications (PTMs) through interactions with folded domains. An IDR linking two α-helices (α1–α2) of the anti-apoptotic protein, Bcl-xL, experie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54281243ca331cdaf816298bdbe2dbdd
https://doi.org/10.1038/s41589-018-0011-x
https://doi.org/10.1038/s41589-018-0011-x
Abstract 5159: Assessing the importance of the kinase domain through kinome-focused CRISPR screening
Autor:
Ahmad Al Kawam, Chaoyang Ye, Fabien Llambi, Klaus P. Hoeflich, Erica Evans, Alexandra R. Grassian
Publikováno v:
Cancer Research. 80:5159-5159
The identification of new therapeutic targets is critical in the fight against cancer. Over the past few decades, the inhibition of kinase cancer drivers has dramatically changed the cancer treatment landscape. Kinases play an important role in modul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c988556276505866175b602722b68fb9
https://doi.org/10.1158/1538-7445.am2020-5159
https://doi.org/10.1158/1538-7445.am2020-5159
Autor:
Jerry E. Chipuk, Parker Merritt, Ariele Viacava Follis, Fabien Llambi, Richard W. Kriwacki, Douglas R. Green
Publikováno v:
Molecular Cell. 59:677-684
The cytosolic fraction of the tumor suppressor p53 activates the apoptotic effector protein BAX to trigger apoptosis. Here we report that p53 activates BAX through a mechanism different from that associated with activation by BH3 only proteins (BIM a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::defba3017ffb163732dc12fb4003b64b
https://doi.org/10.1016/j.molcel.2015.06.029
https://doi.org/10.1016/j.molcel.2015.06.029