Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Fabien Lecomte"'
Autor:
James O’Connell, John Porter, Boris Kroeplien, Tim Norman, Stephen Rapecki, Rachel Davis, David McMillan, Tracy Arakaki, Alex Burgin, David Fox III, Tom Ceska, Fabien Lecomte, Alison Maloney, Alex Vugler, Bruce Carrington, Benjamin P Cossins, Tim Bourne, Alastair Lawson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
While biologics have been successfully applied in TNF antagonist treatments, there are no clinically approved small molecules that target TNF. Here, the authors discover potent small molecule inhibitors of TNF, elucidate their molecular mechanism, an
Externí odkaz:
https://doaj.org/article/cd8aea08c83948d3a69fc5302494dedc
Autor:
Daniel Stöppler, Alex Macpherson, Susanne Smith-Penzel, Nicolas Basse, Fabien Lecomte, Hervé Deboves, Richard D Taylor, Tim Norman, John Porter, Lorna C Waters, Marta Westwood, Ben Cossins, Katharine Cain, James White, Robert Griffin, Christine Prosser, Sebastian Kelm, Amy H Sullivan, David Fox, Mark D Carr, Alistair Henry, Richard Taylor, Beat H Meier, Hartmut Oschkinat, Alastair D Lawson
Publikováno v:
PLoS Biology, Vol 16, Iss 5, p e2006192 (2018)
Aiming at the design of an allosteric modulator of the neonatal Fc receptor (FcRn)-Immunoglobulin G (IgG) interaction, we developed a new methodology including NMR fragment screening, X-ray crystallography, and magic-angle-spinning (MAS) NMR at 100 k
Externí odkaz:
https://doaj.org/article/8aa07cda1edf4eacba469577557c2556
Publikováno v:
Journal of medicinal chemistry. 62(24)
Aldehyde oxidase (AO) catalyzes oxidations of azaheterocycles and aldehydes, amide hydrolysis, and diverse reductions. AO substrates are rare among marketed drugs, and many candidates failed due to poor pharmacokinetics, interspecies differences, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00324ca8cd86dab9407f7fda467113c6
https://pubmed.ncbi.nlm.nih.gov/31385704
https://pubmed.ncbi.nlm.nih.gov/31385704
Autor:
Stephen Hanessian, Stéphane Dorich, Benoît Deschênes-Simard, Juan R. DelValle, Jianbing Zhang, Shyamapada Banerjee, Fabien Lecomte, Ramkrishna Reddy Vakiti
Publikováno v:
ChemInform. 42
The compound is synthesized in 29 linear steps and 3% overall yield starting from a known oxazoline readily available from L-threonine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d7b28caa2d0ccf33a61a3934a6a9c2d
https://doi.org/10.1002/chin.201132199
https://doi.org/10.1002/chin.201132199
Publikováno v:
ChemInform. 40
Aryl Grignard reagents react stereospecifically with alkenyl halides in the presence of manganese chloride (10%) to afford good yields of cross-coupling products.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a55efa914196719b511c435491f35f2
https://doi.org/10.1002/chin.200915062
https://doi.org/10.1002/chin.200915062
Autor:
John Robert Porter, Mark James Batchelor, Fabien Lecomte, Christoph Meier, Jean Keyaerts, Lloyd King, Jose M. Gascon-Simorte, James Thomas Reuberson, Alison Maloney, Kelly Le Riche, Jean Delgado, Mark Daniel Calmiano, Bénédicte Lallemand, Simon Lumb, Anne Marie Foley, Richard J. Franklin, Helen Edwards
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(10)
A series of 4-azaindole inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and series optimisation was performed on the basis of this structure. Future directions for series development ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3985a39d17773e1b2ec299ad573ae58
https://pubmed.ncbi.nlm.nih.gov/19369077
https://pubmed.ncbi.nlm.nih.gov/19369077
Autor:
Jose M. Gascon-Simorte, Mark Daniel Calmiano, James Thomas Reuberson, John B. Porter, Richard J. Franklin, Helen Edwards, Jean Delgado, Alison Maloney, Kelly Le Riche, Mark James Batchelor, Fabien Lecomte, Christoph Meier, Simon Lumb, Anne Marie Foley
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(2)
A series of quinoxaline inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and optimisation of the series was performed on the basis of this structure. Future directions for development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f65a04dc5225bc746bbd873d5d54a69
https://pubmed.ncbi.nlm.nih.gov/19059779
https://pubmed.ncbi.nlm.nih.gov/19059779
Publikováno v:
Organic Letters
Organic Letters, American Chemical Society, 2008, 10 (22), pp.5255-5256. ⟨10.1021/ol802273e⟩
Organic Letters, American Chemical Society, 2008, 10 (22), pp.5255-5256. ⟨10.1021/ol802273e⟩
1 - Article; Aryl Grignard reagents react stereospecifically with alkenyl halides in the presence of manganese chloride (10%) to afford good yields of cross-coupling products.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb88e4fe539cd750640ca30f29ce0d8
https://hal.archives-ouvertes.fr/hal-00462617
https://hal.archives-ouvertes.fr/hal-00462617
Publikováno v:
Organic letters. 8(18)
We describe herein an efficient access to the highly substituted cyclopentane unit present in the Nudifloside secoiridoid family via crotyl phosphonamide anion mediated conjugate addition to cyclopentenone.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b243e3a2031026dedca4ffeed6c9f56
https://pubmed.ncbi.nlm.nih.gov/16928070
https://pubmed.ncbi.nlm.nih.gov/16928070
Publikováno v:
Organic letters. 6(24)
Alkyl- and arylmanganese reagents react with o-chloro or o-bromoaryl ketones to give the substituted ketones in high yields. The cross-coupling reaction is performed under mild conditions (-60 to +40 degrees C, 30 min to 4 h) and takes place with exc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0301ab69072006f5b58b49dbed6584d6
https://pubmed.ncbi.nlm.nih.gov/15548034
https://pubmed.ncbi.nlm.nih.gov/15548034