Methiothepin Increases Chemotherapy Efficacy against Resistant Melanoma Cells

Autor: Nelly Durand, Méliné Simsir, Laurie Signetti, Fabien Labbal, Robert Ballotti, Isabelle Mus-Veteau

Publikováno v: Molecules, Vol 26, Iss 7, p 1867 (2021)

We previously reported that methiothepin, a small molecule known as a nonselective serotonin 5-HT receptor antagonist, inhibited the doxorubicin efflux activity of the Hedgehog receptor Ptch1 and enhanced the cytotoxic, pro-apoptotic, anti-proliferat

Externí odkaz: https://doaj.org/article/a5f7532d31c74354b267061628678f92

Methiothepin Increases Chemotherapy Efficacy against Resistant Melanoma Cells

Autor: Isabelle Mus-Veteau, Laurie Signetti, Robert Ballotti, Nelly Durand, Méliné Simsir, Fabien Labbal

Publikováno v: Molecules
Molecules, 2021, 26 (7), pp.1867. ⟨10.3390/molecules26071867⟩
Molecules, MDPI, 2021, 26 (7), pp.1867. ⟨10.3390/molecules26071867⟩
Molecules, Vol 26, Iss 1867, p 1867 (2021)
Volume 26
Issue 7

We previously reported that methiothepin, a small molecule known as a nonselective serotonin 5-HT receptor antagonist, inhibited the doxorubicin efflux activity of the Hedgehog receptor Ptch1 and enhanced the cytotoxic, pro-apoptotic, anti-proliferat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9eb4057deba4fc56b081a06427d65ea
https://hal.science/hal-03845857/document

NaV1.5 sodium channels increase breast cancer cell invadopodial activity by both controlling Src kinase-dependent F-actin polymerization and promoting NHE-1-dependent proton efflux and extracellular matrix digestion

Autor: Virginie Driffort, Sébastien Roger, Stephan J. Reshkin, Fabien Labbal, Pierre Besson, Mallorie Poët, Ester Antelmi, Lucie Brisson, Lauriane Benoist, Jacques Goré, Stephan Chevalier, Laurent Counillon, Rosa Rubino

Publikováno v: Frontiers in Pharmacology. 5

Background and aim. The degradation of the extracellular matrix (ECM) by cancer cells is a critical essential step in metastatic progression. NaV1.5 sodium channels are overexpressed in breast tumours and associated with metastatic occurrence. NaV1.5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::521faedde408e4923d78217bb9bebaaf
https://doi.org/10.3389/conf.fphar.2014.61.00011

NaV1.5 sodium channels allosterically regulate the NHE-1 exchanger and promote breast cancer cell invadopodial activity

Autor: Stephan Chevalier, Fabien Labbal, Rosa Rubino, Ester Antelmi, Laurent Counillon, Jacques Goré, Sébastien Roger, Lauriane Benoist, Pierre Besson, Mallorie Poët, Virginie Driffort, Stephan J. Reshkin, Lucie Brisson

Publikováno v: Journal of Cell Science.

The degradation of the extracellular matrix by cancer cells represents an essential step in metastatic progression and this is performed by cancer cell structures called invadopodia. NaV1.5 (also known as SCN5A) Na(+) channels are overexpressed in br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c34f84b1876614d7a21b9f9082a626f9
https://doi.org/10.1242/jcs.123901

A human TREK-1/HEK cell line: a highly efficient screening tool for drug development in neurological diseases

Autor: Fabien Labbal, J. Veyssiere, C. Gandin, Catherine Heurteaux, Christelle Devader, Rémi Peyronnet, Jean Mazella, Hamid Moha Ou Maati, Marc Borsotto

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2011, 6 (10), pp.e25602. ⟨10.1371/journal.pone.0025602⟩
PLoS ONE, Vol 6, Iss 10, p e25602 (2011)

International audience; TREK-1 potassium channels are involved in a number of physiopathological processes such as neuroprotection, pain and depression. Molecules able to open or to block these channels can be clinically important. Having a cell mode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1f7b5a023ebfc9580f87d4759b6c377
https://pubmed.ncbi.nlm.nih.gov/22022421