Essential role of GEXP15, a specific Protein Phosphatase type 1 partner, in Plasmodium berghei in asexual erythrocytic proliferation and transmission.

Autor: Thomas Hollin, Caroline De Witte, Aline Fréville, Ida Chiara Guerrera, Cerina Chhuon, Jean-Michel Saliou, Fabien Herbert, Christine Pierrot, Jamal Khalife

Publikováno v: PLoS Pathogens, Vol 15, Iss 7, p e1007973 (2019)

The essential and distinct functions of Protein Phosphatase type 1 (PP1) catalytic subunit in eukaryotes are exclusively achieved through its interaction with a myriad of regulatory partners. In this work, we report the molecular and functional chara

Externí odkaz: https://doaj.org/article/3039ee1299ea489092f6708cca2e5b2d

IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central India.

Autor: Devendra Bansal, Fabien Herbert, Pharath Lim, Prakash Deshpande, Christophe Bécavin, Vincent Guiyedi, Ilaria de Maria, Jean Claude Rousselle, Abdelkader Namane, Rajendra Jain, Pierre-André Cazenave, Gyan Chandra Mishra, Cristiano Ferlini, Constantin Fesel, Arndt Benecke, Sylviane Pied

Publikováno v: PLoS ONE, Vol 4, Iss 12, p e8245 (2009)

BACKGROUND:The main processes in the pathogenesis of cerebral malaria caused by Plasmodium falciparum involved sequestration of parasitized red blood cells and immunopathological responses. Among immune factors, IgG autoantibodies to brain antigens a

Externí odkaz: https://doaj.org/article/f8729f801a994dddbc9a04ea0905f1a4

Plasmodium yoelii Uses a TLR3-Dependent Pathway to Achieve Mammalian Host Parasitism

Autor: Olivier Silvie, Claire Lambert, Jean-Michel Saliou, Pierre-André Cazenave, Marion Draheim, Sylviane Pied, Sophie Salomé-Desnoulez, Tarun Keswani, Delphine Delcroix-Genete, Fabien Herbert, Jacques Roland, Ines Leleu

Publikováno v: Journal of Immunology
Journal of Immunology, 2020, 205 (11), pp.3071-3082. ⟨10.4049/jimmunol.1901317⟩
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2020, 205 (11), pp.3071-3082. ⟨10.4049/jimmunol.1901317⟩

Malaria is associated with complicated immunopathogenesis. In this study, we provide evidence for an unexpected role of TLR3 in promoting the establishment of Plasmodium yoelii infection through delayed clearance of parasitemia in wild type C57BL/6jR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0a65be32d07c2ff29037e6ef10b9291
https://hal.science/hal-03457324

Uptake of parasite-derived vesicles by astrocytes and microglial phagocytosis of infected erythrocytes may drive neuroinflammation in cerebral malaria

Autor: Sylviane Pied, Delphine Delcroix-Genete, Pierre-André Cazenave, Sandeep K. Shrivastava, Fabien Herbert, Esther Dalko

Publikováno v: Glia. 65:75-92

Astrocytes and microglia are activated during cerebral malaria (CM) and contribute to the production and release of several mediators during neuroinflammatory processes. Whether these changes are the consequence of a direct crosstalk between glial ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::686bcfa910faea632d320faa9c9d1cbc
https://doi.org/10.1002/glia.23075

Uptake of parasite-derived vesicles by astrocytes and microglial phagocytosis of infected erythrocytes may drive neuroinflammation in cerebral malaria

Autor: Sandeep K, Shrivastava, Esther, Dalko, Delphine, Delcroix-Genete, Fabien, Herbert, Pierre-André, Cazenave, Sylviane, Pied

Publikováno v: Glia. 65(1)

Astrocytes and microglia are activated during cerebral malaria (CM) and contribute to the production and release of several mediators during neuroinflammatory processes. Whether these changes are the consequence of a direct crosstalk between glial ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::019e3a23d8e3728c935a559a462c8232
https://pubmed.ncbi.nlm.nih.gov/27696532