Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Fabien Guidez"'
Autor:
Camille Sauter, Thomas Morin, Fabien Guidez, John Simonet, Cyril Fournier, Céline Row, Denis Masnikov, Baptiste Pernon, Anne Largeot, Aziza Aznague, Yann Hérault, Guy Sauvageau, Marc Maynadié, Mary Callanan, Jean-Noël Bastie, Romain Aucagne, Laurent Delva
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Arginine methylation is catalyzed by protein arginine methyltransferases (PRMTs) and is involved in various cellular processes, including cancer development. PRMT2 expression is increased in several cancer types although its role in acute my
Externí odkaz:
https://doaj.org/article/967c7436105d4631865893350841f114
Autor:
Qiao Zhou, Jiamin Zhang, Jingsong Zhang, Simin Liang, Duo Cai, Han Xiao, Yu Zhu, Wenqiong Xiang, Fernando Rodrigues-Lima, Jianxiang Chi, Fabien Guidez, Li Wang
Publikováno v:
Biology Direct, Vol 19, Iss 1, Pp 1-16 (2024)
Abstract Background The outcome of Acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) remain dismal despite the development of treatment. Targeted therapy is gaining more and more attention in improving prognosis. Methods Expression of B
Externí odkaz:
https://doaj.org/article/69e8887508ba4eca80fcd4c8700ef8c4
Autor:
Adrienne Anginot, Julie Nguyen, Zeina Abou Nader, Vincent Rondeau, Amélie Bonaud, Maria Kalogeraki, Antoine Boutin, Julia P. Lemos, Valeria Bisio, Joyce Koenen, Lea Hanna Doumit Sakr, Amandine Picart, Amélie Coudert, Sylvain Provot, Nicolas Dulphy, Michel Aurrand-Lions, Stéphane J. C. Mancini, Gwendal Lazennec, David H. McDermott, Fabien Guidez, Claudine Blin-Wakkach, Philip M. Murphy, Martine Cohen-Solal, Marion Espéli, Matthieu Rouleau, Karl Balabanian
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract WHIM Syndrome is a rare immunodeficiency caused by gain-of-function CXCR4 mutations. Here we report a decrease in bone mineral density in 25% of WHIM patients and bone defects leading to osteoporosis in a WHIM mouse model. Imbalanced bone ti
Externí odkaz:
https://doaj.org/article/71e743108c284ff4a7d508b10f487735
Autor:
Maxime Boy, Valeria Bisio, Lin-Pierre Zhao, Fabien Guidez, Bérénice Schell, Emilie Lereclus, Guylaine Henry, Juliette Villemonteix, Fernando Rodrigues-Lima, Katia Gagne, Christelle Retiere, Lise Larcher, Rathana Kim, Emmanuelle Clappier, Marie Sebert, Arsène Mekinian, Olivier Fain, Anne Caignard, Marion Espeli, Karl Balabanian, Antoine Toubert, Pierre Fenaux, Lionel Ades, Nicolas Dulphy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Myelodysplastic syndromes are characterised by clonal haematopoiesis, with the affected cells often harbouring mutations in the TET2 gene, an important regulator of DNA methylation state. Here authors show that the same mutations are also found in NK
Externí odkaz:
https://doaj.org/article/e6f10687f44445c184e49bfa3bcfcf30
Autor:
Baptiste Dumetier, Camille Sauter, Azadeh Hajmirza, Baptiste Pernon, Romain Aucagne, Cyril Fournier, Céline Row, Fabien Guidez, Cédric Rossi, Côme Lepage, Laurent Delva, Mary B. Callanan
Publikováno v:
Biomedicines, Vol 10, Iss 12, p 3101 (2022)
The human genome is composed of unique DNA sequences that encode proteins and unique sequence noncoding RNAs that are essential for normal development and cellular differentiation. The human genome also contains over 50% of genome sequences that are
Externí odkaz:
https://doaj.org/article/5f5066cdd580422a80e9bd38946b3162
Autor:
Carine Domenech, Loïc Maillard, Alix Rousseau, Fabien Guidez, Laurence Petit, Marika Pla, Denis Clay, Fabien Guimiot, Sandra Sanfilippo, Sebastien Jacques, Pierre de la Grange, Noémie Robil, Jean Soulier, Michèle Souyri
Publikováno v:
Stem Cell Reports, Vol 11, Iss 5, Pp 1075-1091 (2018)
Summary: Fanconi anemia (FA) causes bone marrow failure early during childhood, and recent studies indicate that a hematopoietic defect could begin in utero. We performed a unique kinetics study of hematopoiesis in Fancg−/− mouse embryos, between
Externí odkaz:
https://doaj.org/article/2024629cfb7e43a39e101694dd4fdb9c
Autor:
Laura Guerenne, Stéphanie Beurlet, Mohamed Said, Petra Gorombei, Carole Le Pogam, Fabien Guidez, Pierre de la Grange, Nader Omidvar, Valérie Vanneaux, Ken Mills, Ghulam J Mufti, Laure Sarda-Mantel, Maria Elena Noguera, Marika Pla, Pierre Fenaux, Rose Ann Padua, Christine Chomienne, Patricia Krief
Publikováno v:
Journal of Hematology & Oncology, Vol 9, Iss 1, Pp 1-20 (2016)
Abstract Background In spite of the recent discovery of genetic mutations in most myelodysplasic (MDS) patients, the pathophysiology of these disorders still remains poorly understood, and only few in vivo models are available to help unravel the dis
Externí odkaz:
https://doaj.org/article/5f34a28afe924b7bb0e3dc96b14f7206
Autor:
Saravanan Ganesan, Sarah Awan-Toor, Fabien Guidez, Nabih Maslah, Celine Aoun, Panhong Gou, Chloe Guiguen, Juliette Soret, Odonchimeg Ravdan, Valeria Bisio, Nicolas Dulphy, Marie-Hélène Schlageter, Michele Souyri, Stephane Giraudier, Jean-Jacques Kiladjian, Christine Chomienne, Bruno Cassinat
Publikováno v:
Blood. 140:3852-3854
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16f9bf867c436905b8416b01a87276d7
https://doi.org/10.1182/blood-2022-157490
https://doi.org/10.1182/blood-2022-157490
Autor:
Jean-Marie Dupret, Valentina Sirri, Li Wang, Linh-Chi Bui, Louise Le Coadou, Christina Michail, Christine Chomienne, Jérémy Berthelet, Fabien Guidez, Nicolas Dulphy, Fernando Rodrigues-Lima
Publikováno v:
Molecular Pharmacology
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2021, 100 (3), pp.283-294. ⟨10.1124/molpharm.121.000303⟩
Molecular Pharmacology, 2021, 100 (3), pp.283-294. ⟨10.1124/molpharm.121.000303⟩
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2021, 100 (3), pp.283-294. ⟨10.1124/molpharm.121.000303⟩
Molecular Pharmacology, 2021, 100 (3), pp.283-294. ⟨10.1124/molpharm.121.000303⟩
Human SETD2 is the unique histone methyltransferase that generates H3K36 trimethylation (H3K36me3), an epigenetic mark that plays a key role in normal hematopoiesis. Interestingly, recurrent inactivating mutations of SETD2 and aberrant H3K36me3 are i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d84ce066d4d6f46f49eab9b15c5858b
https://doi.org/10.1124/molpharm.121.000303
https://doi.org/10.1124/molpharm.121.000303
Autor:
Adrienne Anginot, Julie Nguyen, Zeina Abou-Nader, Vincent Rondeau, Amélie Bonaud, Antoine Boutin, Julia Lemos, Valeria Bisio, Joyce Koenen, Léa Sakr, Caroline Marty, Amélie Coudert, Sylvain Provot, Nicolas Dulphy, Michel Aurrand-Lions, Stéphane Mancini, Gwendal lazennec, David McDermott, Fabien Guidez, Claudine Blin-Wakkach, Philip Murphy, Martine Cohen-Solal, Marion Espeli, Matthieu Rouleau, Karl Balabanian
WHIM Syndrome (WS) is a rare immunodeficiency caused by gain-of-function CXCR4 mutations. Here we report for the first time a substantial decrease in bone mineral density in 25% of WS patients and bone defects leading to osteoporosis in a WS mouse mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a2c465578a90e004eda3dd24cea6e9c
https://doi.org/10.21203/rs.3.rs-1186490/v1
https://doi.org/10.21203/rs.3.rs-1186490/v1
