Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Fabien Faivre"'
Autor:
Mayalen Oxoby, François Moreau, Elodie Drocourt, Dmytro Atamanyuk, Benoit Ledoussal, Vincent Gerusz, Fabien Faivre
Publikováno v:
Journal of Medicinal Chemistry. 56:1908-1921
In this paper, we present different strategies to vectorize HldE kinase inhibitors with the goal to improve their gram-negative intracellular concentration. Syntheses and biological effects of siderophoric, aminoglycosidic, amphoteric, and polycation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0bb30726e6c11eeafb71465e3a9f57b
https://doi.org/10.1021/jm400097h
https://doi.org/10.1021/jm400097h
Autor:
Cédric Raymond, François Moreau, Laure Prouvensier, Jean-Marie Genevard, Yannick Bonvin, Lionel Durant, Laëtitia Peltier, Armelle Walton, Coralie Soulama-Mouze, Stéphanie Floquet, Elodie Drocourt, Vincent Gerusz, Mayalen Oxoby, Sonia Escaich, Géraldine LeFralliec, Vanessa Sam-Sambo, Vanida Vongsouthi, Nicolas Desroy, Marc Saccomani, Chrystelle Oliveira, Sophia Briet, Alexis Denis, Fabien Faivre
Publikováno v:
Journal of Medicinal Chemistry. 55:9914-9928
In this paper, we present some elements of our optimization program to decouple triclosan's specific FabI effect from its nonspecific cytotoxic component. The implementation of this strategy delivered highly specific, potent, and nonbiocidal new FabI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8cec45f475491713180acfabe1b6f5a
https://doi.org/10.1021/jm301113w
https://doi.org/10.1021/jm301113w
Autor:
Nicolas Desroy, Vanida Vongsouthi, Stéphanie Floquet, Dmytro Atamanyuk, Vincent Gerusz, Géraldine LeFralliec, François Moreau, Theodore B. Verhey, Ting-Wai Lee, Lionel Durant, Yannick Bonvin, Sophia Briet, Alexis Denis, Mayalen Oxoby, Fabien Faivre, Elodie Drocourt, Sonia Escaich, Chrystelle Oliveira, Murray S. Junop
Publikováno v:
Journal of medicinal chemistry. 56(4)
We report here the optimization of an HldE kinase inhibitor to low nanomolar potency, which resulted in the identification of the first reported compounds active on selected E. coli strains. One of the most interesting candidates, compound 86, was sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2890016c6843ce1a2e7be486ac05f257
https://pubmed.ncbi.nlm.nih.gov/23409840
https://pubmed.ncbi.nlm.nih.gov/23409840