Výsledky vyhledávání - "Fabien Dutheil"

Akademický článek

Immunotherapy and radiotherapy for older patients with invasive bladder cancer unfit for surgery or chemotherapy: practical proposal by the international geriatric radiotherapy group

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

The standard of care for non-metastatic muscle invasive bladder cancer is either radical cystectomy or bladder preservation therapy, which consists of maximal transurethral bladder resection of the tumor followed by concurrent chemoradiation with a c

Externí odkaz: https://doaj.org/article/1b9b4ae746574ac99e9dd725ac79bc5e

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Akademický článek

Immunotherapy and stereotactic body radiotherapy for older patients with non-metastatic renal cancer unfit for surgery or decline nephrectomy: practical proposal by the International Geriatric Radiotherapy Group

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

The standard of care for non-metastatic renal cancer is surgical resection followed by adjuvant therapy for those at high risk for recurrences. However, for older patients, surgery may not be an option due to the high risk of complications which may

Externí odkaz: https://doaj.org/article/7f4f299900d84a7fb975ba8f1f50b0ec

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Akademický článek

Immunotherapy and radiotherapy for older patients with locally advanced rectal cancer unfit for surgery or decline surgery: a practical proposal by the International Geriatric Radiotherapy Group

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

The standard of care for locally advanced rectal cancer is total neoadjuvant therapy followed by surgical resection. Current evidence suggests that selected patients may be able to delay or avoid surgery without affecting survival rates if they achie

Externí odkaz: https://doaj.org/article/fcae2a7e40a64cc8a76831978eeb850f

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Akademický článek

Retrospective study on the toxicity induced by stereotactic body radiotherapy: overview of the reunion experience on prostate cancer in elderly patients

Autor: Youssef Slama, Gilles Baumont, Angelique Arcambal, Mickael Begue, Olivier Maillot, Rima Sayah, Romain Castanet, Raoul Caboche, Pedro Liberati, Hakim Slaoui, Medi Bouaziz, Olivier Borson, Nam P. Nguyen, Fabien Dutheil

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

IntroductionProstate cancer is the fourth most commonly diagnosed cancer among men worldwide. Various tools are used to manage disease such as conventional radiotherapy. However, it has been demonstrated that large prostate volumes were often associa

Externí odkaz: https://doaj.org/article/7805c3926f2740b7aaec536180d56ab3

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Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function

Autor: Monique Diry, Magnus Ingelman-Sundberg, Ivan Bièche, Véronique Sazdovitch, Marie-Anne Loriot, Xavier Declèves, Philippe Beaune, Jean-Pierre Flinois, Olivier Cloarec, Fabien Dutheil, Isabelle de Waziers, Lucille Mellottee, Charles Duyckaerts, Sandrine Dauchy

Publikováno v: Drug Metabolism and Disposition. 37:1528-1538

Cytochrome P450 (P450) enzymes and ATP-binding cassette (ABC) transporters modulate the transport and metabolism of both endogenous and exogenous substrates and could play crucial roles in the human brain. In this study, we report the transcript expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e730535b6fbddf183a684c6df982b851
https://doi.org/10.1124/dmd.109.027011

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NMR metabolomic of frontal cortex extracts First study comparing two neurodegenerative diseases, Alzheimer disease and amyotrophic lateral sclerosis

Autor: L. Le Moyec, Fabien Dutheil, Mohamed N. Triba, Carole Marbeuf-Gueye, Marie-Anne Loriot, Philippe Beaune, E.P. Botosoa, M. Zhu, C. Duyckaerts

Publikováno v: IRBM
IRBM, 2012, 33 (5-6), pp.281-286. ⟨10.1016/j.irbm.2012.08.002⟩
Innovation and Research in BioMedical engineering
Innovation and Research in BioMedical engineering, 2012, 33 (5-6), pp.281-286. ⟨10.1016/j.irbm.2012.08.002⟩

International audience; Objective This study was designed to assess the brain metabolites' variability between two neurodegenerative diseases in frontal cortex samples obtained post-mortem. NMR metabolomics was used for the first time in this context

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313ff271d17005b0da2cb49ff5a434af
https://hal-univ-evry.archives-ouvertes.fr/hal-02489961

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ABC transporters and cytochromes P450 in the human central nervous system: influence on brain pharmacokinetics and contribution to neurodegenerative disorders

Autor: Fabien Dutheil, Aude Jacob, Philippe Beaune, Sandrine Dauchy, Jean-Michel Scherrmann, Xavier Declèves, Marie-Anne Loriot

Publikováno v: Expert opinion on drug metabolismtoxicology. 6(10)

The identification of xenobiotic metabolizing enzymes (i.e., CYP) and transporters (i.e., ABC transporters) (XMET) in the human brain, including the BBB, raises the question whether these transporters and enzymes have specific functions in brain phys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e5998069a3d6b871575dc683ed665a
https://pubmed.ncbi.nlm.nih.gov/20843279

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Interaction between ABCB1 and professional exposure to organochlorine insecticides in Parkinson disease

Autor: Fabien Dutheil, Christophe Tzourio, Marie-Anne Loriot, Philippe Beaune, Alexis Elbaz

Publikováno v: Archives of neurology. 67(6)

Objective To study the association between Parkinson disease (PD) and 2 polymorphisms in ABCB1 among subjects enrolled in the French health system for agricultural workers (Mutualite Sociale Agricole), as well as the interaction between ABCB1 and org

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299ae19e0e65bf931eec61f1cb5a112d
https://pubmed.ncbi.nlm.nih.gov/20558393

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ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier

Autor: Xavier Declèves, Catherine Daumas-Duport, Sandrine Dauchy, Isabelle de Waziers, Richard J. Weaver, Fabien Dutheil, Jean-Michel Scherrmann, Pierre-Olivier Couraud, Francine Chassoux

Publikováno v: Journal of neurochemistry. 107(6)

We have established the expression patterns of the genes encoding ATP-binding cassette (ABC) transporters and cytochromes P450 (CYPs) at the adult human blood–brain barrier (BBB) using isolated brain microvessels and cortex biopsies from patients w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5659ac314c18104b6df0bc4ae7c7052f
https://pubmed.ncbi.nlm.nih.gov/19094056

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Xenobiotic metabolizing enzymes in the central nervous system: Contribution of cytochrome P450 enzymes in normal and pathological human brain

Autor: Philippe Beaune, Fabien Dutheil, Marie-Anne Loriot

Publikováno v: Biochimie. 90(3)

The metabolism of xenobiotics in human brain constitutes a field of recent intensive research in relation to the potential implications in the pharmacological effect of drugs acting on the central nervous system. Cytochrome P450 enzymes (CYPs) play a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d3cfcc86ca60781c3319e1592f77d5
https://pubmed.ncbi.nlm.nih.gov/17997991

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