Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Fabien Crozet"'
Autor:
Nathalie Souyris, Fabien Crozet, Christian Behrens, Céline Monnet, Alexandra Jacquet, Sylvie Jorieux, Ouafa Zaki, Khalil Bouayadi, Alexandre Fontayne, Nathalie Fournier, Rémi Urbain, Christophe De Romeuf, Philippe Mondon
Publikováno v:
mAbs. 6:422-436
While glyco-engineered monoclonal antibodies (mAbs) with improved antibody-dependent cell-mediated cytotoxicity (ADCC) are reaching the market, extensive efforts have also been made to improve their pharmacokinetic properties to generate biologically
Autor:
Fabien Crozet, Magali Remaud-Simeon, Hakim Kharrat, Philippe Mondon, Gabrielle Potocki-Véronèse, Sandra Pizzut-Serin, Pierre Monsan, Khalil Bouayadi, Laurent Douchy, Stéphane Emond
Publikováno v:
Protein Engineering, Design and Selection. 21:267-274
The in vitro MutaGen procedure is a new random mutagenesis method based on the use of low-fidelity DNA polymerases. In the present study, this technique was applied on a 2 kb gene encoding amylosucrase, an attractive enzyme for the industrial synthes
Autor:
Michèle Crozatier, Laurence Dubois, Fabien Crozet, Gaelle Lebreton, Virginie Daburon, Jonathan Enriquez, Alain Vincent
Publikováno v:
Development (Cambridge, England)
Development (Cambridge, England), Company of Biologists, 2007, 134 (24), pp.4347-4355. ⟨10.1242/dev.008409⟩
Development (Cambridge, England), Company of Biologists, 2007, 134 (24), pp.4347-4355. ⟨10.1242/dev.008409⟩
International audience; Specification of muscle identity in Drosophila is a multistep process: early positional information defines competence groups termed promuscular clusters, from which muscle progenitors are selected, followed by asymmetric divi
Autor:
Fabien Crozet, Hakim Kharrat, Nathalie Souyris, Philippe Mondon, Khalil Bouayadi, Laurent Douchy
Publikováno v:
Biotechnology Journal. 2:76-82
The selection of antibody fragments from libraries using in vitro screening technologies has proven to be a very good alternative to the classical hybridoma technology, and has overcome the laborious process of antibody humanization. However, the com
Publikováno v:
Current Biology. 8:1027-1030
During somitogenesis, cells are recruited to the caudal presomitic mesoderm (PSM) from the primitive streak (and later the tail bud), while somites separate from the rostral end as epithelial cubes [1]. This is a regular process, one somite forming e
Autor:
Christine Petit, Fabienne Levi-Acobas, Hassan Chaib, Dominique Weil, Fabien Crozet, Jacqueline Levilliers, Catherine Dodé, Parry Guilford
Publikováno v:
Genomics. 47:125-130
We report on the isolation and initial characterization of a human α-tubulin gene named TUBA2. This gene is located in the 13q11 region and has been considered a candidate gene for two nonsyndromic deafnesses, DFNB1 and DFNA3. The gene, with a minim
Autor:
Danièle Depétris, Chantal Ripoll, Christian P. Hamel, Marc Lenoir, Fabien Crozet, Rémy Pujol, Dominique Weil, Fabienne Levi-Acobas, Stéphane Blanchard, P. Vago, Christine Petit, Cécile Fizames, Marie-Geneviève Mattei, Aziz El Amraoui
Publikováno v:
Genomics
Genomics, 1997, 40 (2), pp.332-341. ⟨10.1006/geno.1996.4526⟩
Genomics, 1997, 40 (2), pp.332-341. ⟨10.1006/geno.1996.4526⟩
Several lines of evidence indicate a crucial role for unconventional myosins in the function of the sensory hair cells of the inner ear. We report here the characterization of the cDNAs encoding two unconventional type I myosins from a mouse cochlear
Autor:
Fabien Crozet, J. C. Kaplan, Stéphane Blanchard, Denis Le Paslier, Daniel Cohen, Jean Weissenbach, Hassan Chaib, Catherine Dodé, Dominique Weil, Christine Petit, Parry Guilford, Jacqueline Levilliers, Fabienne Levi-Acobas
Publikováno v:
Genomics. 29:163-169
Two forms of inherited childhood nonsyndromic deafness (DFNB1 and DFNA3) and a Duchenne-like form of progressive muscular dystrophy (LGMD2C) have been mapped to the pericentromeric region of chromosome 13. To clone the genes responsible for these dis
Autor:
Christine Petit, Iman Sahly, Fabienne Levi-Acobas, Stéphane Blanchard, Karen M. Steel, Gallia Levy, Fabien Crozet, Dominique Weil, Steve D.M. Brown, Marc Abitbol, Arnold Munnich, Josseline Kaplan
Publikováno v:
Annales de l'Institut Pasteur / Actualités. 6:300-303
Le syndrome de Usher associe une surdite congenitale et une retinite pigmentaire evolutive. Il comprend trois formes cliniques qui se transmettent toutes selon le mode autosomique recessif. Le type I designe la forme la plus grave; au moins quatre ge
Autor:
Laurence, Renaut, Céline, Monnet, Olivier, Dubreuil, Ouafa, Zaki, Fabien, Crozet, Khalil, Bouayadi, Hakim, Kharrat, Philippe, Mondon
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 907
As a growing number of therapeutic antibodies are developed, robust methods to efficiently improve the affinity and/or specificity of antibody candidates are needed. Here we describe our powerful platform that combines scFv affinity maturation and Ig