Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Fabien Crauste"'
Autor:
Sarah Cadot, Chloe Audebert, Charlotte Dion, Soleakhena Ken, Loic Dupré, Laetitia Largeaud, Camille Laurent, Loic Ysebaert, Fabien Crauste, Anne Quillet-Mary
Publikováno v:
PLoS Medicine, Vol 21, Iss 7, p e1004430 (2024)
BackgroundOne of the first clinical observations of ibrutinib activity in the treatment of chronic lymphocytic leukemia (CLL) is a rapid decline in lymph nodes size. This phenomenon is accompanied by an hyperlymphocytosis, either transient or prolong
Externí odkaz:
https://doaj.org/article/f17d8dafc0d34daa9927d03be3be13de
Autor:
Shaoying Wang, Margaux Prieux, Simon de Bernard, Maxence Dubois, Daphne Laubreton, Sophia Djebali, Manon Zala, Christophe Arpin, Laurent Genestier, Yann Leverrier, Olivier Gandrillon, Fabien Crauste, Wenzheng Jiang, Jacqueline Marvel
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109411- (2024)
Summary: To investigate the impact of paracrine IL-2 signals on memory precursor (MP) cell differentiation, we activated CD8 T cell in vitro in the presence or absence of exogenous IL-2 (ex-IL-2). We assessed memory differentiation by transferring th
Externí odkaz:
https://doaj.org/article/766f356fd3814da3a67463be388ba58d
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0301022 (2024)
Germinal centers (GCs) are the key histological structures of the adaptive immune system, responsible for the development and selection of B cells producing high-affinity antibodies against antigens. Due to their level of complexity, unexpected malfu
Externí odkaz:
https://doaj.org/article/34a8e24d7caa4f94a3ac13044fa9e85b
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-21 (2021)
Abstract Background Nonlinear mixed effects models provide a way to mathematically describe experimental data involving a lot of inter-individual heterogeneity. In order to assess their practical identifiability and estimate confidence intervals for
Externí odkaz:
https://doaj.org/article/e16495b99d2b4deba666532c33d64f1b
Autor:
Helena Todorov, Margaux Prieux, Daphne Laubreton, Matteo Bouvier, Shaoying Wang, Simon de Bernard, Christophe Arpin, Robrecht Cannoodt, Wouter Saelens, Arnaud Bonnaffoux, Olivier Gandrillon, Fabien Crauste, Yvan Saeys, Jacqueline Marvel
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104927- (2022)
Summary: In this work, we studied the generation of memory precursor cells following an acute infection by analyzing single-cell RNA-seq data that contained CD8 T cells collected during the postinfection expansion phase. We used different tools to re
Externí odkaz:
https://doaj.org/article/f4e14db1143b47a392370f939ac3a6b9
Autor:
Elena Merino Tejero, Danial Lashgari, Rodrigo García-Valiente, Xuefeng Gao, Fabien Crauste, Philippe A. Robert, Michael Meyer-Hermann, María Rodríguez Martínez, S. Marieke van Ham, Jeroen E. J. Guikema, Huub Hoefsloot, Antoine H. C. van Kampen
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Germinal centers play a key role in the adaptive immune system since they are able to produce memory B cells and plasma cells that produce high affinity antibodies for an effective immune protection. The mechanisms underlying cell-fate decisions are
Externí odkaz:
https://doaj.org/article/b71fd22486ec46cba1fbea77e5755481
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Activation of naive CD8 T-cells can lead to the generation of multiple effector and memory subsets. Multiple parameters associated with activation conditions are involved in generating this diversity that is associated with heterogeneous molecular co
Externí odkaz:
https://doaj.org/article/1f9d318a872d472db29a044f3e16337e
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0225166 (2019)
To better understand the mechanisms behind cells decision-making to differentiate, we assessed the influence of stochastic gene expression (SGE) modulation on the erythroid differentiation process. It has been suggested that stochastic gene expressio
Externí odkaz:
https://doaj.org/article/09936ecb0e9248fc8d2b2db611a6cee2
Autor:
Sotiris A. Prokopiou, Loic Barbarroux, Samuel Bernard, Julien Mafille, Yann Leverrier, Christophe Arpin, Jacqueline Marvel, Olivier Gandrillon, Fabien Crauste
Publikováno v:
Computation, Vol 2, Iss 4, Pp 159-181 (2014)
CD8 T-cells are critical in controlling infection by intracellular pathogens. Upon encountering antigen presenting cells, T-cell receptor activation promotes the differentiation of naïve CD8 T-cells into strongly proliferating activated and effector
Externí odkaz:
https://doaj.org/article/29751bd1a2a3493d83671086a9a95ab2
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100073 (2014)
Dynamics of body weight and food intake can be studied by temporally perturbing food availability. This perturbation can be obtained by modifying the amount of available food over time while keeping the overall food quantity constant. To describe foo
Externí odkaz:
https://doaj.org/article/de849c87d2b54410a1a7ec05f666918c