Towards real-time release of pharmaceutical tablets: 100% in-line control via near-infrared spatially resolved spectroscopy and 3D microwave resonance technology

Autor: Yves Roggo, Fabien Chauchard, Markus Krumme, Davinia Brouckaert, Freddy Vandenbroucke, Laurent Pellegatti, Martial Dollinger

Publikováno v: Journal of pharmaceutical and biomedical analysis. 209

In the scope of 100% in-line quality control and real-time release of pharmaceutical tablets, the authors present a flexible inspection module for in-line tablet analysis with integrated multipoint near-infrared (NIR) spectroscopy and 3D microwave re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f7a3c810f0df15745803ced101654b
https://pubmed.ncbi.nlm.nih.gov/34875571

Use of near-infrared spectroscopy and multipoint measurements for quality control of pharmaceutical drug products

Autor: Fabien Chauchard, Mathieu Boiret

Publikováno v: Analytical and Bioanalytical Chemistry. 409:683-691

Near-infrared (NIR) spectroscopy is a non-destructive analytical technique that enables better-understanding and optimization of pharmaceutical processes and final drug products. The use in line is often limited by acquisition speed and sampling area

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2614425997daca6bc32340a60d0aca25
https://doi.org/10.1007/s00216-016-9756-9

Real-time monitoring of antibody glycosylation site occupancy by in situ Raman spectroscopy during bioreactor CHO cell cultures

Autor: Meng-Yao Li, Emmanuel Guedon, Annie Marc, Fabien Chauchard, Bruno Ebel, Cédric Paris

Publikováno v: Biotechnology Progress
Biotechnology Progress, Wiley, 2018, 34 (2), pp.486-493. ⟨10.1002/btpr.2604⟩

The glycosylation of therapeutic monoclonal antibodies (mAbs), a known critical quality attribute, is often greatly modified during the production process by animal cells. It is essential for biopharmaceutical industries to monitor and control this g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5978ce54d632b471eb4db86d5b40c929
https://pubmed.ncbi.nlm.nih.gov/29314747

Application of LS-SVM to non-linear phenomena in NIR spectroscopy: development of a robust and portable sensor for acidity prediction in grapes

Autor: R. Cogdill, Sylvie Roussel, Fabien Chauchard, Véronique Bellon-Maurel, Jean-Michel Roger

Publikováno v: Chemometrics and Intelligent Laboratory Systems
Chemometrics and Intelligent Laboratory Systems, Elsevier, 2004, 71 (2), p. 141-p. 150. ⟨10.1016/j.chemolab.2004.01.003⟩

Un des enjeux majeurs de spectroscopie NIR est le transfert des méthodes développées en laboratoire vers le domaine industriel pour des applications en ligne ou portable. Il apparaît ainsi de nouvelles problématiques telles que la nécessité de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10bd7d2041b7850ac2e97a4e0ac93ffa
https://doi.org/10.1016/j.chemolab.2004.01.003

Multivariate Data Analysis (Chemometrics)

Autor: Sylvie Roussel, Sébastien Preys, Jordane Lallemand, Fabien Chauchard

Publikováno v: Food Engineering Series ISBN: 9781493903108

Chemometrics plays a key role in PAT strategies. It is essential in understanding and diagnosing real-time processes, and keeping them under multivariate statistical control. This chapter will cover design of experiments, exploratory analysis, quanti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2068e8641bc84172e5fe96175e4160ea
https://doi.org/10.1007/978-1-4939-0311-5_2