Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Fabien C Coyan"'
Autor:
Fabien C Coyan, Fayal Abderemane-Ali, Mohamed Yassine Amarouch, Julien Piron, Jérôme Mordel, Céline S Nicolas, Marja Steenman, Jean Mérot, Céline Marionneau, Annick Thomas, Robert Brasseur, Isabelle Baró, Gildas Loussouarn
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e93255 (2014)
INTRODUCTION:Phosphatidylinositol-4,5-bisphosphate (PIP2) is a cofactor necessary for the activity of KCNQ1 channels. Some Long QT mutations of KCNQ1, including R243H, R539W and R555C have been shown to decrease KCNQ1 interaction with PIP2. A previou
Externí odkaz:
https://doaj.org/article/2457806624d04ecea1b5be87c18b48d5
Autor:
Frank S Choveau, Fayal eAbderemane-Ali, Fabien C Coyan, Zeineb eEs-Salah-Lamoureux, Isabelle eBaro, Gildas eLoussouarn
Publikováno v:
Frontiers in Pharmacology, Vol 3 (2012)
Voltage-gated potassium (Kv) channels are tetramers, each subunit presenting six transmembrane segments (S1-S6), with each S1-S4 segments forming a voltage-sensing domain (VSD) and the four S5-S6 forming both the conduction pathway and its gate. S4 s
Externí odkaz:
https://doaj.org/article/905354626e3f4895b355789880175805
Autor:
Gildas Loussouarn, Joan Heller Brown, Sophie Burel, Fabien C. Coyan, Jeanne M. Nerbonne, Flavien Charpentier, Lars S. Maier, Cheryl F. Lichti, Matthew R. Meyer, Maxime Lorenzini, Raymond R. Townsend, Céline Marionneau
Publikováno v:
The Journal of biological chemistry, vol 292, iss 42
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2017, Equipe IIa, 292 (42), pp.17431--17448. ⟨10.1074/jbc.M117.787788⟩
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2017, Equipe IIa, 292 (42), pp.17431--17448. ⟨10.1074/jbc.M117.787788⟩
International audience; Voltage-gated Na(+) (NaV) channels are key regulators of myocardial excitability, and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-dependent alterations in NaV1.5 channel inactivation are emerging as a critical deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783c484ce95d855b98e1da8261ddac12
https://escholarship.org/uc/item/2rz48167
https://escholarship.org/uc/item/2rz48167
Autor:
Sophie, Burel, Fabien C, Coyan, Maxime, Lorenzini, Matthew R, Meyer, Cheryl F, Lichti, Joan H, Brown, Gildas, Loussouarn, Flavien, Charpentier, Jeanne M, Nerbonne, R Reid, Townsend, Lars S, Maier, Céline, Marionneau
Publikováno v:
The Journal of biological chemistry. 292(42)
Voltage-gated Na+ (NaV) channels are key regulators of myocardial excitability, and Ca2+/calmodulin-dependent protein kinase II (CaMKII)-dependent alterations in NaV1.5 channel inactivation are emerging as a critical determinant of arrhythmias in hea
Autor:
Flavien Charpentier, Lars S. Maier, Cheryl Litchi, Céline Marionneau, Sophie Burel, R. Reid Townsend, Matthew R. Meyer, Maxime Lorenzini, Joan Heller Brown, Fabien C. Coyan, Jeanne M. Nerbonne
Publikováno v:
Archives of Cardiovascular Diseases Supplements. 8(3)
Aims Voltage-gated Na+ (NaV) channels are key regulators of myocardial excitability, determining depolarization, duration, waveform and refractoriness of action potentials. In heart failure, action potentials are prolonged, and evidence suggests that
Autor:
Jeanne M. Nerbonne, Joan Heller Brown, Sophie Burel, Fabien C. Coyan, R. Reid Townsend, Cheryl F. Lichti, Flavien Charpentier, Céline Marionneau, Lars S. Maier
Publikováno v:
Archives of Cardiovascular Diseases Supplements. 6
Voltage-gated Na+ (Nav) channels are key determinants of myocardial excitability and defects in Nav channel functioning or regulation, associated with inherited and acquired cardiac disease, increase the risk of life-threatening arrhythmias. In heart
Autor:
Céline Marionneau, Gildas Loussouarn, Julien Piron, Mohamed Yassine Amarouch, Robert Brasseur, Marja Steenman, Isabelle Baró, Céline Nicolas, Jean Mérot, Jérôme Mordel, Fabien C. Coyan, Annick Thomas, Fayal Abderemane-Ali
Publikováno v:
PLoS ONE
PLoS ONE, Public Library of Science, 2014, 9 (3), pp.e93255. ⟨10.1371/journal.pone.0093255⟩
PLoS ONE, Vol 9, Iss 3, p e93255 (2014)
PLoS ONE, Public Library of Science, 2014, 9 (3), pp.e93255. ⟨10.1371/journal.pone.0093255⟩
PLoS ONE, Vol 9, Iss 3, p e93255 (2014)
Introduction Phosphatidylinositol-4,5-bisphosphate (PIP2) is a cofactor necessary for the activity of KCNQ1 channels. Some Long QT mutations of KCNQ1, including R243H, R539W and R555C have been shown to decrease KCNQ1 interaction with PIP2. A previou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7beb7951ad43c136f344a077f838a23
https://hal.archives-ouvertes.fr/hal-02363771
https://hal.archives-ouvertes.fr/hal-02363771
Autor:
Gildas Loussouarn, Fabien C. Coyan
Publikováno v:
Channels. 7:415-416
Alteration of membrane cholesterol is accompanied by the modification of the activity of many ion channels, as detailed in 2010 in a thorough review article.1 This observation may have some pathoph...
Autor:
Céline Marionneau, Isabelle Baró, Julien Piron, Gildas Loussouarn, Annick Thomas, Mohamed Yassine Amarouch, Robert Brasseur, Fayal Abderemane Ali, Fabien C. Coyan, Marja Steenman, Céline Nicolas, Jean Mérot, Jérôme Mordel
Publikováno v:
ResearcherID
Phosphatidylinositol-4,5-bisphosphate (PIP2) is a membrane cofactor necessary for the activity of KCNQ1 channels. Some Long QT mutations of KCNQ1, including R243H, R539W and R555C have been shown to decrease KCNQ1 interaction with PIP2. A previous st
Autor:
Sophie Burel, Flavien Charpentier, Céline Marionneau, Joan Heller Brown, Fabien C. Coyan, Cheryl F. Lichti, R. Reid Townsend, Jeanne M. Nerbonne, Lars M. Maier
Publikováno v:
Biophysical Journal. (2):37a
Voltage-gated Na+ (Nav) channels are key determinants of myocardial excitability and defects in Nav channel functioning or regulation, associated with inherited and acquired cardiac disease, increase the risk of life-threatening arrhythmias. In heart