Asymmetric Titanium-Catalyzed Cyclopropanation of Nitriles with Grignard Reagents

Autor: Julien Caillé, Paul Setzer, Fabien Boeda, Morwenna S. M. Pearson-Long, Philippe Bertus

Publikováno v: SynOpen, Vol 02, Iss 01, Pp 0041-0049 (2018)

Abstract The titanium-catalyzed asymmetric cyclopropanation of cyanoesters­ with Grignard reagents was investigated for the first time. Particularly, the study of the efficiency of Taddol-based titanium complexes­ has shown that the prior preparati

Externí odkaz: https://doaj.org/article/57eac40f7d6c43efae980f840200ffce

Heteromultifunctional Oxazolones as Versatile Linkers for Click Chemistry Reactions

Autor: Fabien Boeda, Laurent Fontaine, Mathilde Pantin, Philippe Bertus, M. S. M. Pearson-Long, Julien Caillé

Publikováno v: European Journal of Organic Chemistry. 2019:7359-7366

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a14585ada00148568d2957cd0e2753d
https://doi.org/10.1002/ejoc.201901350

Zinc-Mediated Double Addition on Functionalized Nitriles

Autor: Philippe Bertus, M. S. M. Pearson-Long, Julien Caillé, Fabien Boeda, Mathilde Pantin

Publikováno v: SYNTHESIS
SYNTHESIS, Georg Thieme Verlag, 2019, 51 (06), pp.1329-1341. ⟨10.1055/s-0037-1611704⟩

International audience; Allylzinc reagents were used to access highly functionalized tertiary carbinamine derivatives in high yields from cyanoesters and cyanocarbonates. While the monoaddition of organometallics on nitriles is generally observed, in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea06229ccf55110bad0c483e69ea45a5
https://hal.archives-ouvertes.fr/hal-02132643

Synthesis and biological evaluation of 3-cyano-4H-chromene derivatives bearing carbamate functionality

Autor: Fatma Boukattaya, Fabien Boeda, Philippe Bertus, Neji Gharsallah, Adel Kadri, M. S. M. Pearson-Long, Houcine Ammar, Amal Daoud

Publikováno v: Medicinal Chemistry
Medicinal Chemistry, Bentham Science Publishers, 2018, 14, ⟨10.2174/1573406414666181009124449⟩

Background: 2-Aminochromene derivatives display important pharmacological properties, including mainly antibiotic and anticancer activities. Objective: The study aims to synthesize new chromene derivatives via a new approach using Grignard reagents,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::225cbaaf054b353fa69647a726b14ff8
https://hal-univ-lemans.archives-ouvertes.fr/hal-01921815

Successive addition of two different Grignard reagents to nitriles: access to α,α-disubstituted propargylamine derivatives

Autor: Fabien Boeda, Julien Caillé, Houcine Ammar, M. S. M. Pearson-Long, Philippe Bertus, Fatma Boukattaya

Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2018, 16 (9), pp.1519-1526. ⟨10.1039/c7ob03047a⟩

International audience; The successive addition of two different Grignard reagents to acyl cyanohydrins was performed with success by taking advantage of the low reactivity of alkynyl Grignard reagents. The experimental conditions were adjusted so th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54575339be909f2ee96bc32d124a0c61
https://hal-univ-lemans.archives-ouvertes.fr/hal-01914744