Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Fabien Binamé"'
Autor:
Fabien Binamé, Lucas D Pham‐Van, Caroline Spenlé, Valérie Jolivel, Dafni Birmpili, Lionel A Meyer, Laurent Jacob, Laurence Meyer, Ayikoé G Mensah‐Nyagan, Chrystelle Po, Michaël Van der Heyden, Guy Roussel, Dominique Bagnard
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 11, Pp n/a-n/a (2019)
Abstract Current treatments in multiple sclerosis (MS) are modulating the inflammatory component of the disease, but no drugs are currently available to repair lesions. Our study identifies in MS patients the overexpression of Plexin‐A1, the signal
Externí odkaz:
https://doaj.org/article/9c93a265f0e349ccb476894277fab549
Autor:
Valérie Jolivel, Susana Brun, Fabien Binamé, Jérémie Benyounes, Omar Taleb, Dominique Bagnard, Jérôme De Sèze, Christine Patte-Mensah, Ayikoe-Guy Mensah-Nyagan
Publikováno v:
Cells, Vol 10, Iss 3, p 698 (2021)
Microglial cells are key players in neural pathogenesis and microglial function regulation appears to be pivotal in controlling neuroinflammatory/neurological diseases. Here, we investigated the effects and mechanism of action of neurosteroid allopre
Externí odkaz:
https://doaj.org/article/56041ace58d848b0b70fecb739a9e217
Autor:
Frank Maus, Dominik Sakry, Fabien Binamé, Khalad Karram, Krishnaraj Rajalingam, Colin Watts, Richard Heywood, Rejko Krüger, Judith Stegmüller, Hauke B Werner, Klaus-Armin Nave, Eva-Maria Krämer-Albers, Jacqueline Trotter
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137311 (2015)
The NG2 proteoglycan is characteristically expressed by oligodendrocyte progenitor cells (OPC) and also by aggressive brain tumours highly resistant to chemo- and radiation therapy. Oligodendrocyte-lineage cells are particularly sensitive to stress r
Externí odkaz:
https://doaj.org/article/4bd26238ae5b4408949dac8491530e13
Autor:
Dominik Sakry, Angela Neitz, Jeet Singh, Renato Frischknecht, Daniele Marongiu, Fabien Binamé, Sumudhu S Perera, Kristina Endres, Beat Lutz, Konstantin Radyushkin, Jacqueline Trotter, Thomas Mittmann
Publikováno v:
PLoS Biology, Vol 12, Iss 11, p e1001993 (2014)
The role of glia in modulating neuronal network activity is an important question. Oligodendrocyte precursor cells (OPC) characteristically express the transmembrane proteoglycan nerve-glia antigen 2 (NG2) and are unique glial cells receiving synapti
Externí odkaz:
https://doaj.org/article/d70a5bd4aee94c9396a0636c718d1f1b
Autor:
Constantin Gonsior, Fabien Binamé, Carsten Frühbeis, Nina M Bauer, Peter Hoch-Kraft, Heiko J Luhmann, Jacqueline Trotter, Robin White
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89423 (2014)
Oligodendrocytes are the myelinating glial cells of the central nervous system. In the course of brain development, oligodendrocyte precursor cells migrate, scan the environment and differentiate into mature oligodendrocytes with multiple cellular pr
Externí odkaz:
https://doaj.org/article/5908eabe2cb343aa87ce6c4ac3624f45
Autor:
Nicolas Collongues, Guillaume Becker, Valérie Jolivel, Estelle Ayme-Dietrich, Jérôme de Seze, Fabien Binamé, Christine Patte-Mensah, Laurent Monassier, Ayikoé Guy Mensah-Nyagan
Publikováno v:
Neurology and Therapy. 11:981-1042
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) resulting in demyelination and neurodegeneration. The therapeutic strategy is now largely based on reducing inflammation with immunosuppressive drugs. Unfor
Publikováno v:
Cellular and molecular life sciences : CMLS. 78(13)
In demyelinated lesions, astrocytes, activated microglia and infiltrating macrophages secrete several factors regulating oligodendrocyte precursor cells' behaviour. What appears to be the initiation of an intrinsic mechanism of myelin repair is only
Autor:
Bertille Montibus, Fabien Binamé, Léo Piquet, Valérie Lagrée, Laure Magnan, Aurélien Bidaud-Meynard, Anne Chabadel, Violaine Moreau, Frédéric Saltel
Publikováno v:
The Journal of Cell Biology
p190RhoGAP (p190A) is a negative regulator of RhoA and localizes to membrane protrusions, where its GAP activity is required for directional migration. Here, Binamé et al. identify the protrusion-localization sequence in p190A and show that cancer-a
Autor:
Klemens Rottner, Jean-Baptiste Sibarita, Amanda Remorino, Matthias Schaks, Violaine Moreau, Fabien Binamé, Mathieu Coppey, Zeynep Karatas, Olivier Rossier, Anaël Chazeau, Grégory Giannone, Amine Mehidi
Publikováno v:
Current Biology-CB
Current Biology-CB, Elsevier, 2019, 29 (17), pp.2852-2866.e5. ⟨10.1016/j.cub.2019.07.035⟩
Current Biology-CB, 2019, 29 (17), pp.2852-2866.e5. ⟨10.1016/j.cub.2019.07.035⟩
Current Biology-CB, Elsevier, 2019, 29 (17), pp.2852-2866.e5. ⟨10.1016/j.cub.2019.07.035⟩
Current Biology-CB, 2019, 29 (17), pp.2852-2866.e5. ⟨10.1016/j.cub.2019.07.035⟩
International audience; The spatiotemporal coordination of actin regulators in the lamellipodium determines the dynamics and architecture of branched F-actin networks during cell migration. The WAVE regulatory complex (WRC), an effector of Rac1 durin
Autor:
Verena Opitz, Julia Bruttger, Mirko H. H. Schmidt, Stefanie Keller, Betty Jurek, Tobias Bäuerle, Fabien Binamé, René Gollan, Frank Bicker, Michael K. E. Schäfer, Frauke Zipp, Jérôme Birkenstock, Valérie Jolivel, Robert Ploen, Laura Poisa-Beiro, Serge C. Thal, Ari Waisman
Publikováno v:
Acta Neuropathologica. 129:279-295
The contribution of microglia to ischemic cortical stroke is of particular therapeutic interest because of the impact on the survival of brain tissue in the ischemic penumbra, a region that is potentially salvable upon a brain infarct. Whether or not