Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Fabien Bertaux"'
Autor:
Fabien Bertaux, Erich E. Wanker, Kirupa Sathasivam, Dave T. Shima, Amabirpal Mahal, Ben Woodman, Gillian P. Bates
Publikováno v:
Human Molecular Genetics. 10:2425-2435
Huntington's disease (HD) is a progressive neurological disorder caused by a CAG/polyglutamine repeat expansion. We have previously generated the R6/2 mouse model that expresses exon 1 of the human HD gene containing CAG repeats in excess of 150. The
Autor:
Gillian P. Bates, Amarbirpal Mahal, Erich E. Wanker, Carl Hobbs, Kirupa Sathasivam, Stephen W. Davies, Fabien Bertaux, Patrick Doherty, Laura Mangiarini, Mark Turmaine
Publikováno v:
Scopus-Elsevier
Huntington's disease (HD) is one of a class of inherited progressive neurodegenerative disorders that are caused by a CAG/polyglutamine repeat expansion. We have previously generated mice that are transgenic for exon 1 of the HD gene carrying highly
Autor:
Roberto DiLauro, Alena Donda, Françoise N. Javaux, Helen Francis-Lang, Fabien Bertaux, Gilbert Vassart, Daniel Christophe
Publikováno v:
FEBS Letters. 300:222-226
We have studied the binding of purified TTF-1 on the bovine thyroglobulin gene promoter. DNase I footprinting experiments revealed three binding sites which corresponded in location to the A, B and C sites found in the rat thyroglobulin promoter. Mut
Publikováno v:
FEBS letters. 581(18)
Autotaxin is a member of the phosphodiesterase family of enzymes, (NPP2). It is an important secreted protein found in conditioned medium from adipocytes. It also has a putative role in the metastatic process. Based on these observation, further vali
Autor:
Erich E. Wanker, Christopher A. Ross, Alan H. Sharp, Gillian P. Bates, Hans Lehrach, Fabien Bertaux
Publikováno v:
FEBS letters. 426(2)
HAP1 (huntingtin associated protein) has previously been found to interact with huntingtin (htt) in a glutamine length dependent manner and has been proposed to play a role in the cell specific neurodegeneration observed in Huntington's disease (HD).
Autor:
Kirupa Sathasivam, Hans Lehrach, Fabien Bertaux, Ichiro Kanazawa, Laura Mangiarini, Sarah Baxendale, Colin Hetherington, Gillian P. Bates
Publikováno v:
Human molecular genetics. 6(12)
The puffer fish ( Fugu rubripes ) has a compact genome of 400 Mbp which is approximately 7.5-fold smaller than the human genome. It contains a similar number of genes but is deficient in intergenic, intronic and dispersed repetitive sequences. Fugu i
Publikováno v:
Gene. 156(2)
The human thyroglobulin (hTg)-encoding gene is a single-copy gene of more than 300 kb and composed of at least 42 exons. After studying the 5' portion of the Tg cDNA (from nucleotides (nt) 1 to 842), we have previously suggested the existence of alte