The DAV132 colon-targeted adsorbent does not interfere with plasma concentrations of antibiotics but prevents antibiotic-related dysbiosis: a randomized phase I trial in healthy volunteers

Autor: Meriem Messaoudene, Stéphanie Ferreira, Nathalie Saint-Lu, Mayra Ponce, Caroline Truntzer, Romain Boidot, Clément Le Bescop, Thomas Loppinet, Tanguy Corbel, Céline Féger, Karine Bertrand, Arielle Elkrief, Morten Isaksen, Fabien Vitry, Frédérique Sablier-Gallis, Antoine Andremont, Lloyd Bod, François Ghiringhelli, Jean de Gunzburg, Bertrand Routy

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Abstract The deleterious impact of antibiotics (ATB) on the microbiome negatively influences immune checkpoint inhibitors (ICI) response in patients with cancer. We conducted a randomized phase I study (EudraCT:2019-A00240-57) with 148 healthy volunt

Externí odkaz: https://doaj.org/article/654c4f9e81204f8999feefb9a049aabe

278 Systematic review and meta-analysis evaluating the impact of antibiotic use on clinical outcomes of non-small-cell lung cancer patients treated with immune checkpoint inhibitors

Autor: Pierre-Alain Bandinelli, Julie Cervesi, Clément Le Bescop, Renaud Buffet, Jean De Gunzburg, Gérard Zalcman, Athéna Crespin, Fabien Vitry

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

Externí odkaz: https://doaj.org/article/f038b988af4e4f2aa6a84d70788e368b

Genome-edited, donor-derived allogeneic anti-CD19 chimeric antigen receptor T cells in paediatric and adult B-cell acute lymphoblastic leukaemia: results of two phase 1 studies

Autor: Reuben Benjamin, Charlotte Graham, Deborah Yallop, Agnieszka Jozwik, Oana C Mirci-Danicar, Giovanna Lucchini, Danielle Pinner, Nitin Jain, Hagop Kantarjian, Nicolas Boissel, Marcela V Maus, Matthew J Frigault, André Baruchel, Mohamad Mohty, Athos Gianella-Borradori, Florence Binlich, Svetlana Balandraud, Fabien Vitry, Elisabeth Thomas, Anne Philippe, Sylvain Fouliard, Sandra Dupouy, Ibtissam Marchiq, Maria Almena-Carrasco, Nicolas Ferry, Sylvain Arnould, Cyril Konto, Paul Veys, Waseem Qasim, Antonio Pagliuca, Ghulam Mufti, Piers Patten, Shireen Kassam, Stephen Devereux, Majid Kazmi, Kirsty Cuthill, Victoria Potter, Andrea Kuhnl, Victoria Metaxa, Laarni Bonganay, Orla Stewart, Rose Ellard, Lorraine Catt, Jen Lewis, Farzin Farzaneh, Jackie Chappell, Alice Mason, Vicky Chu, Alan Dunlop, Adeel Saleem, Gary Cheung, Helena Munro, Elka Giemza, Oana Ciocarlie, Jan Chu, Persis Amrolia, Kanchan Rao, Robert Chiesa, Juliana Silva, Annette Hill, Maria Finch, Lindsey Young, Harvinder Hara, Sujith Samarasinghe, Anupama Rao, Ajay Vora, Kimberley Gilmour, Christine Rivat, Clare Murphy, Gulrukh Ahsan, Rasha Said Shamsah, Jesmina James, Sarah Inglott, Gary Wright, Stuart Adams, Natalia Izotova, Marina Konopleva, William Wierda, Elias Jabbour, Partow Kebrieai, Emily Jones, Kara McGee, Marcela Maus, Matthew Frigault, Jami Brown, Vesselina Toncheva, Keagan Casey, Hanno Hock, Meaghan A McKeown, Richard Mathews, Thomas Spitzer, Emmanuel Raffoux, Etienne Lengliné, Raphael Itzykson, Florence Rabian, Jérôme Larghero, Isabelle Madelaine, Elie Azoulay, Emmanuelle Clappier, Sophie Caillat-Zucman, Martine Meunier, Karine Celli-Lebras, Marie-Thérèse Tremorin, Karima Yakouben, Françoise Mechinaud-Heloury, Audrey Grain, Aurélia Alimi, Julie Roupret, Delphine Chaillou, Hélène Cavé, Aurelie Caye-Eude, Odile Fenneteau, Elodie Lainey, Jerome Naudin, Eolia Brissot, Remy Dulery, Florent Malard, Clémence Mediavilla, Agnès Bonnin, Anne Vekhoff, Tounes Ledraa, Anne Daguenel-Nguyen

Publikováno v: The Lancet. 396:1885-1894

Summary Background Genome-edited donor-derived allogeneic anti-CD19 chimeric antigen receptor (CAR) T cells offer a novel form of CAR-T-cell product that is available for immediate clinical use, thereby broadening access and applicability. UCART19 is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec40a8b13cd2746d839da37388e3ee8
https://doi.org/10.1016/s0140-6736(20)32334-5

An open randomized multicentre Phase 2 trial to assess the safety of DAV132 and its efficacy to protect gut microbiota diversity in hospitalized patients treated with fluoroquinolones

Autor: Maria J. G. T. Vehreschild, Annie Ducher, Thomas Louie, Oliver A. Cornely, Celine Feger, Aaron Dane, Marina Varastet, Fabien Vitry, Jean de Gunzburg, Antoine Andremont, France Mentré, Mark H. Wilcox

Publikováno v: The Journal of antimicrobial chemotherapy. 77(4)

Background DAV132 (colon-targeted adsorbent) has prevented antibiotic-induced effects on microbiota in healthy volunteers. Objectives To assess DAV132 safety and biological efficacy in patients. Patients and methods An open-label, randomized [stratif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae1927f1f4705d4f7f7d230791f8a51
https://pubmed.ncbi.nlm.nih.gov/35016205

Spare and repair the gut microbiota from antibiotic-induced dysbiosis: state-of-the-art

Autor: Antoine Andremont, Julie Cervesi, Fabien Vitry, Pierre-Alain Bandinelli, Jean de Gunzburg

Publikováno v: Drug discovery today. 26(9)

Homeostasis of the intestinal microbiota is currently recognized as a major contributor to human health. Furthermore, intestinal dysbiosis is associated with a multitude of consequences, including intestinal colonization by antibiotic-resistant or pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea471de5c335597750928676dfc49b58
https://pubmed.ncbi.nlm.nih.gov/33639249